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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/10 23:21:05」(JST)

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Bromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties.^[1]

Function [edit]

Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract.

It is secretolytic, increasing the production of serous mucus in the respiratory tract and makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect by helping the cilia transport the phlegm out of the lungs. For this reason it is often added to cough syrups.

Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport".

Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The posology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is well established and tolerated.

Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin.

Brand names [edit]

Bisolvon
Hoesttabletten Bromhexine HCl
Paxirasol
Barkacin
Vasican
Bisolex
Robitussin Chesty/Forte
Duro-Tuss Chesty
Benadryl Chesty/Forte
Movex
Bromex
Solvex

References [edit]

^ Morton, Ian; Hall, Judith (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. Retrieved 2009-06-03.

UpToDate Contents

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1. 慢性閉塞性肺疾患（COPD）治療における粘膜作用剤の役割 role of mucoactive agents in the treatment of copd
2. 小児における感冒：治療および予防 the common cold in children treatment and prevention
3. 安定した慢性閉塞性肺疾患（COPD）のマネージメント management of stable chronic obstructive pulmonary disease
4. 成人における気管支拡張症の治療 treatment of bronchiectasis in adults
5. シェーグレン症候群における口内乾燥およびその他の非眼結膜炎症状の治療 treatment of dry mouth and other non ocular sicca symptoms in sjogrens syndrome

English Journal

Biotransformation of bromhexine by Cunninghamella elegans, C. echinulata and C. blakesleeana.

Dube AK1, Kumar MS2.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].Braz J Microbiol.2016 Dec 5. pii: S1517-8382(16)31173-X. doi: 10.1016/j.bjm.2016.11.003. [Epub ahead of print]
Fungi is a well-known model used to study drug metabolism and its production in in vitro condition. We aim to screen the most efficient strain of Cunninghamella sp. among C. elegans, C. echinulata and C. blakesleeana for bromhexine metabolites production. We characterized the metabolites produced us
PMID 27988088

Effects of ambroxol hydrochloride on concentrations of paclitaxel and carboplatin in lung cancer patients at different administration times.

Li J1, Yi W2, Jiang P2, Sun R2, Li T2.
Cellular and molecular biology (Noisy-le-Grand, France).Cell Mol Biol (Noisy-le-grand).2016 Nov 30;62(13):85-89. doi: 10.14715/cmb/2016.62.13.15.
Our previous preliminary study revealed a synergistic effect of ambroxol hydrochloride with chemotherapeutic agents such as paclitaxel and carboplatin in lung cancer. However, the optimal conditions such as administration time and drug concentration of ambroxol hydrochloride to achieve the maximum s
PMID 28040066

Simultaneous determination of ambroxol and salbutamol in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.

Guo Z1,2, Chen Y3, Ding X1, Huang C1, Miao L4,5.
Biomedical chromatography : BMC.Biomed Chromatogr.2016 Nov;30(11):1789-1795. doi: 10.1002/bmc.3754. Epub 2016 Jun 19.
A rapid, selective and sensitive liquid chromatography-tandem mass spectrometry assay method was developed for simultaneous determination of ambroxol and salbutamol in human plasma using citalopram hydrobromide as internal standard (IS). The sample was alkalinized with ammonia water (33:67, v/v) and
PMID 27129716

Japanese Journal

去痰薬の使い方

呼吸器内科 = Respiratory medicine 29(2), 170-176, 2016-02
NAID 40020797085

味覚と嗅覚に関する感性バイオセンサ

YAKUGAKU ZASSHI 134(3), 307-312, 2014
NAID 130003391167

P1-18-4 アレルギー性気管支肺アスペルギルス症による粘液栓の排痰に,気管支鏡下のbromhexine投与が著効した1例(症例-4,一般演題ポスター,第36回日本呼吸器内視鏡学会学術集会)

気管支学 35(Special), S230, 2013
NAID 110009702163

Related Pictures

15 Effective Wet & Dry Cough Medicines for Kids and Adults Bromhexine Bromhexine Hydrochloride Tablets at Rs 190 /30 tablets | Vadodara | ID: 5040289862 Bromhexine Syrup Manufacturers,Bromhexine Syrup Suppliers Exporters in India BISOLVON (BROMHEXINE) 160MG 120ML *THIS PRODUCT IS ONLY AVAILABLE IN MEXICO - Farmacia

★リンクテーブル★

リンク元	「ブロムヘキシン」
拡張検索	「bromhexine hydrochloride」

「ブロムヘキシン」

Bromhexine
Systematic (IUPAC) name
	2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	A (Aus)
Legal status	?
Pharmacokinetic data
Bioavailability	75-80%
Half-life	12 hr
Identifiers
CAS number	3572-43-8
ATC code	R05CB02
PubChem	CID 2442
ChemSpider	2348
UNII	Q1J152VB1P
KEGG	D07542
ChEMBL	CHEMBL253376
Chemical data
Formula	C14H20Br2N2
Mol. mass	376.13
	SMILES Brc1cc(c(N)c(Br)c1)CN(C)C2CCCCC2;
	InChI InChI=1S/C14H20Br2N2/c1-18(12-5-3-2-4-6-12)9-10-7-11(15)8-13(16)14(10)17/h7-8,12H,2-6,9,17H2,1H3 ; Key:OJGDCBLYJGHCIH-UHFFFAOYSA-N ;
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