bovine herpesvirus 4

• ウシヘルペスウイルス4型

WordNet

1. dull and slow-moving and stolid; like an ox; "showed a bovine apathy"
2. any of various members of the genus Bos
3. of or relating to or belonging to the genus Bos (cattle) (同)bovid

PrepTutorEJDIC

1. 牛の;牛のような / のっそりした,鈍重な / ウシ科の動物

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/10/02 06:50:02」(JST)

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Bovine herpesvirus 4
Virus classification
Group:	Group I (dsDNA)
Family:	Herpesviridae
Genus:	Rhadinovirus
Species:	Bovine herpesvirus 4 (BHV-4)

Bovine herpesvirus 4 is a member of the Herpesviridae family. It is part of the subfamily Gammaherpesvirinae and genus Rhadinovirus. Infection is normally sub-clinical but can cause reproductive disease in cattle such as endometritis, vulvovaginitis and mastitis. Transmission is both vertical and horizontal. It can also be indirectly spread by fomites. Distribution is worldwide and the virus infects a range of ruminants, including bison, buffalo, sheep and goats.

The disease may also be referred to as passenger virus and moyar virus.

Clinical Signs & Diagnosis

BHV-4 infection is often subclinical, with no observable clinical signs. However the virus may cause abortion and retained foetal membranes, and if an infected fetus is born alive it may be weak. It can also cause mastitis in dairy cattle. It may be isolated from conjunctivitis and respiratory disease cases but it is unknown whether the EHV-4 is a primary or opportunistic pathogen in these cases.

Diagnosis is achieved by virus isolation (from tissues or secretions), PCR, ELISA, and indirect immunofluorescence. Because BHV-4 infection can be asymptomatic, the presence of the virus does not confirm that it was the cause of the observed clinical signs.

Treatment & Control

Treatment is symptomatic. The virus can remain latent in recovered animals - shedding at times of stress, allowing the spread of disease to others. Appropriate hygiene and isolation measures can control disease. Vaccines exist in the USA but are not widely used.

See also

• Bovine herpesvirus (disambiguation)
• Bovine herpesvirus 1
• Bovine herpesvirus 2
• Bovine herpesvirus 5

References

• Bovine Herpesvirus 4, reviewed and published by WikiVet at http://en.wikivet.net/Bovine_Herpesvirus_4, accessed 14/08/2011.

UpToDate Contents

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English Journal

• BoHV-4-based vector delivering Ebola virus surface glycoprotein.

• Rosamilia A1, Jacca S1, Tebaldi G1, Tiberti S1, Franceschi V1, Macchi F1, Cavirani S1, Kobinger G2, Knowles DP3, Donofrio G4.
• Journal of translational medicine.J Transl Med.2016 Nov 24;14(1):325.
• BACKGROUND: Ebola virus (EBOV) is a Category A pathogen that is a member of Filoviridae family that causes hemorrhagic fever in humans and non-human primates. Unpredictable and devastating outbreaks of disease have recently occurred in Africa and current immunoprophylaxis and therapies are limited.
• PMID 27881138

• Virus-Mediated Metalloproteinase 1 Induction Revealed by Transcriptome Profiling of Bovine Herpesvirus 4-Infected Bovine Endometrial Stromal Cells.

• Tebaldi G1, Jacca S1, Montanini B2, Capra E3, Rosamilia A1, Sala A1, Stella A3, Castiglioni B3, Ottonello S2, Donofrio G4.
• Biology of reproduction.Biol Reprod.2016 Jul;95(1):12. doi: 10.1095/biolreprod.116.139097. Epub 2016 Jun 8.
• Viral infections can cause genital tract disorders (including abortion) in cows, and bovine herpesvirus 4 (BoHV-4) is often present in endometritis-affected animals. A major problem with cattle uterine viral infections in general, and BoHV-4 in particular, is our limited understanding of the pathoge
• PMID 27281703

• The role of herpesviruses (BoHV-1 and BoHV-4) and pestiviruses (BVDV and BDV) in ruminant abortion cases in western Turkey.

• Tuncer-Göktuna P1, Alpay G1, Öner EB1, Yeşilbağ K2.
• Tropical animal health and production.Trop Anim Health Prod.2016 Jun;48(5):1021-7. doi: 10.1007/s11250-016-1050-5. Epub 2016 Apr 1.
• The economic impact of abortions in ruminant breeders is one of the biggest problems in livestock. Of the infectious agents, viruses, especially herpesviruses and pestiviruses, are the most important causative agents of abortion in ruminants. In the present study, the role of herpesviruses (bovine h
• PMID 27038195

Japanese Journal

• Epidemiology and genetic characterization of BVDV, BHV-1, BHV-4, BHV-5 and Brucella spp. infections in cattle in Turkey

• ASLAN Muhammet Eren,AZKUR Ahmet Kursat,GAZYAGCI Serkal
• Journal of Veterinary Medical Science advpub(0), 2015
• … The aim of the study was to determine the epidemiological data of bovine viral diarrhea virus (BVDV), bovine herpesvirus-1 (BHV-1), bovine herpesvirus-4 (BHV-4), bovine herpesvirus-5 (BHV-5) and Brucella–associated cattle that were previously reported to have abortion and infertility problems in Ankara, Corum, Kirikkale and Yozgat provinces, Turkey. …
• NAID 130005077866

• Efficacy of five commercial disinfectants and one anionic surfactant against equine herpesvirus type 1

• TSUJIMURA Koji,MURASE Harutaka,BANNAI Hiroshi,NEMOTO Manabu,YAMANAKA Takashi,KONDO Takashi
• Journal of Veterinary Medical Science advpub(0), 2015
• … We investigated the influences of various reaction conditions on equine herpesvirus type 1 (EHV-1) disinfection by 5 commercial disinfectants (3 quaternary ammonium compounds [QACs] and 2 chlorine-based disinfectants) and 1 anionic surfactant. … In the presence of 5% fetal bovine serum, QACs (except for benzalkonium chloride) showed more stable virucidal effects than did chlorine-based disinfectants. …
• NAID 130005075576

• Effect of Supplemental Vitamin E on Antibody Titer in Japanese Black Calves Vaccinated against Bovine Herpesvirus-1

• OTOMARU Konosuke,SAITO Shun,ENDO Karura [他],KOHIRUIMAKI Masayuki,FUKUYAMA Shin-ichi,OHTSUKA Hiromichi
• Journal of Veterinary Medical Science 75(12), 1671-1673, 2013
• … We investigated the effect of supplemental vitamin E on antibody titer against bovine herpesvirus-1 (BHV-1) in Japanese Black calves after vaccination with modified live virus. …
• NAID 130003362281

Related Links

• Bovine Herpesvirus 4 - WikiVet English

Introduction BHV-4 is a member of the Herpesvirus causing reproductive disease in cattle in the form of endometritis, vulvovaginitis, associated abortion and mastitis. Most disease is however, subclinical, hence its common name of ...

• The biology of bovine herpesvirus-4 infection of cattle.

1. Dtsch Tierarztl Wochenschr. 1990 Feb;97(2):72-7. The biology of bovine herpesvirus-4 infection of cattle. Thiry E(1), Dubuisson J, Bublot M, Van Bressem MF, Pastoret PP. Author information: (1)Department ...

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関連記事	「bovine」「herpesvirus」「herpesviruses」「bovine herpesvirus」

「bovine」

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Bos taurus、cattle、ox、oxen

　 　 　 　

「herpesvirus」

　　[★] ヘルペスウイルス科、ヘルペスウイルス

「herpesviruses」

　　[★] ヘルペスウイルス科、ヘルペスウイルス

「bovine herpesvirus」

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• ウシヘルペスウイルス