WordNet
- complicated in structure; consisting of interconnected parts; "a complex set of variations based on a simple folk melody"; "a complex mass of diverse laws and customs"
- a compound described in terms of the central atom to which other atoms are bound or coordinated (同)coordination_compound
- a conceptual whole made up of complicated and related parts; "the complex of shopping malls, houses, and roads created a new town" (同)composite
- (psychoanalysis) a combination of emotions and impulses that have been rejected from awareness but still influence a persons behavior
PrepTutorEJDIC
- 『いくつかの部分から成る』,複合の,合成の / 『複雑な』,入りくんだ,こみいった(complicated) / 複合体,合成物 / コンプレックス,複合(抑圧されて心に残った複雑なしこり)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/04/15 22:09:10」(JST)
[Wiki en表示]
Homeobox gene expression in
Drosophila melanogaster
The Bithorax complex (BX-C) is a group of homeotic genes in Drosophila melanogaster which are believed to control the differentiation of the abdominal and posterior thoracic segments, located on chromosome III.[1] When these genes are mutated, the third thoracic segment becomes a repeat of the second thoracic segment, creating what is essentially a second thorax. This can result in a second pair of wings, a second stomach, and duplicated thoracic features in varying degrees.[2]
The complex includes Ultrabithorax (Ubx), Abdominal A (abd-A) and Abdominal B (Abd-B).[3]
Calvin Bridges discovered Bithorax (mutation/gene) in the fly in 1915; after that, Edward B. Lewis named and worked on the Bithorax complex[4] and proposed a model in a classic Nature paper in 1978 and was given a Nobel Prize.[5]
References
- ^ McGinnis, W.; Levine, M. S.; Hafen, E.; Kuroiwa, A.; Gehring, W. J. (1984). "A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes". Nature 308 (5958): 428–33. doi:10.1038/308428a0. PMID 6323992.
- ^ Dang, KD; Dutt, PB; Forsdyke, DR (1998). "Chargaff difference analysis of the bithorax complex of Drosophila melanogaster". Biochemistry and Cell Biology 76 (1): 129–37. doi:10.1139/bcb-76-1-129. PMID 9666315.
- ^ Developmental biology. Scott F. Gilbert
- ^ Crow, JF; Bender, W (2004). "Edward B. Lewis, 1918-2004". Genetics 168 (4): 1773–83. PMC 1448758. PMID 15611154.
- ^ Lewis, E. B. (1978). "A gene complex controlling segmentation in Drosophila". Nature 276 (5688): 565–70. doi:10.1038/276565a0. PMID 103000.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- The Border between the Ultrabithorax and abdominal-A Domains in the Drosophila Bithorax Complex.
- Bender W, Lucas M.SourceHarvard Medical School;
- Genetics.Genetics.2013 Jan 3. [Epub ahead of print]
- The bithorax complex in Drosophila melanogaster includes three homeobox-containing genes, Ultrabithorax (Ubx), abdominal-A (abd-A), and Abdominal-B (Abd-B), which are required for the proper differentiation of the posterior ten segments of the body. Each of these genes has multiple distinct regulato
- PMID 23288934
- Conserved boundary elements from the Hox complex of mosquito, Anopheles gambiae.
- Ahanger SH, Srinivasan A, Vasanthi D, Shouche YS, Mishra RK.SourceNational Centre for Cell Science, Pune 411007, India.
- Nucleic acids research.Nucleic Acids Res.2013 Jan;41(2):804-16. doi: 10.1093/nar/gks1178. Epub 2012 Dec 4.
- The conservation of hox genes as well as their genomic organization across the phyla suggests that this system of anterior-posterior axis formation arose early during evolution and has come under strong selection pressure. Studies in the split Hox cluster of Drosophila have shown that proper express
- PMID 23221647
- [Drosophila Fab-7 insulator effectively blocks polycomb-mediated repression in transgenic lines].
- Kyrchanova OV, Georgiev PG.AbstractThe bithorax complex (BX-C) genes have a regulatory region containing nine independent parasegment-specific enhancers. Inactivation of the enhancers is a result of Pc-mediated repression, which leads to the appearance of active and repressed domains. Active domains are supposed to be separated from the repressed domains by insulators on the domain boundaries. Three insulators were found in the BX-C by the ability to block enhancers intransgenic model systems. It is shown that one of these three well studied insulators, Fab-7, is able to protect the yellow gene transcription against the most powerful Polycomb-dependent silencer from the bxd regulatory domain of the Ultra-bithorax gene (Ubx). The barrier activity requires a region containing GAF-binding sites. Interestingly, the silencer used in the model system (1.5 kb PRE from the regulatory region of Ubx) recruits a transgenic construct with a frequency of up to 47% into genomic regions that completely repress the yellow gene expression.
- Genetika.Genetika.2012 Mar;48(3):307-14.
- The bithorax complex (BX-C) genes have a regulatory region containing nine independent parasegment-specific enhancers. Inactivation of the enhancers is a result of Pc-mediated repression, which leads to the appearance of active and repressed domains. Active domains are supposed to be separated from
- PMID 22679777
Japanese Journal
- Mapping polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin
- Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin
- Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less
Related Links
- Bithorax complex (BX-C) designates the cluster of homeotic genes that specify the identities of posterior segments in Drosophila Melanogaster. Homeodomain Transcription Factors ... Editors Prof. Detlev Ganten Prof. Ruckpaul Klaus
- FINE-STRUCTURE MAPPING AND THE cis-trans TEST There were two major influences on Lewis's early work. The first was an old idea, that new genes arise by duplication of an ancestral gene, followed by ...
Related Pictures
★リンクテーブル★
[★]
- 英
- bithorax complex
- 関
- バイソラックス遺伝子群
[★]
- 英
- bithorax complex
- 関
- 双胸複合体
[★]
- 関
- complexes、complicated、composite、conjugate、intricate
[★]
- 関
- hybrid、mixed lineage、mixed type、mixed-type
[★]
- 関
- complex、composite
[★]