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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/03 05:22:14」(JST)
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Homeobox gene expression in
Drosophila melanogaster
The Bithorax complex (BX-C) is a group of homeotic genes in Drosophila melanogaster which are believed to control the differentiation of the abdominal and posterior thoracic segments, located on chromosome III.[1] When these genes are mutated, the third thoracic segment becomes a repeat of the second thoracic segment, creating what is essentially a second thorax. This can result in a second pair of wings, a second stomach, and duplicated thoracic features in varying degrees.[2]
The complex includes Ultrabithorax (Ubx), Abdominal A (abd-A) and Abdominal B (Abd-B).[3]
Calvin Bridges discovered Bithorax (mutation/gene) in the fly in 1915; after that, Edward B. Lewis named and worked on the Bithorax complex[4] and proposed a model in a classic Nature paper in 1978 and was given a Nobel Prize.[5]
References
- ^ McGinnis, W.; Levine, M. S.; Hafen, E.; Kuroiwa, A.; Gehring, W. J. (1984). "A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes". Nature. 308 (5958): 428–33. doi:10.1038/308428a0. PMID 6323992.
- ^ Dang, KD; Dutt, PB; Forsdyke, DR (1998). "Chargaff difference analysis of the bithorax complex of Drosophila melanogaster". Biochemistry and Cell Biology. 76 (1): 129–37. doi:10.1139/bcb-76-1-129. PMID 9666315.
- ^ Developmental biology. Scott F. Gilbert
- ^ Crow, JF; Bender, W (2004). "Edward B. Lewis, 1918-2004". Genetics. 168 (4): 1773–83. PMC 1448758. PMID 15611154.
- ^ Lewis, E. B. (1978). "A gene complex controlling segmentation in Drosophila". Nature. 276 (5688): 565–70. doi:10.1038/276565a0. PMID 103000.
English Journal
- Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers, Core Promoters and Gene Insulators.
- Kwon SY1, Grisan V1, Jang B1, Herbert J1, Badenhorst P1.
- PLoS genetics.PLoS Genet.2016 Apr 5;12(4):e1005969. doi: 10.1371/journal.pgen.1005969. eCollection 2016.
- NURF is a conserved higher eukaryotic ISWI-containing chromatin remodeling complex that catalyzes ATP-dependent nucleosome sliding. By sliding nucleosomes, NURF is able to alter chromatin dynamics to control transcription and genome organization. Previous biochemical and genetic analysis of the spec
- PMID 27046080
- Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.
- Becker H1, Renner S1, Technau GM1, Berger C1.
- PLoS genetics.PLoS Genet.2016 Mar 25;12(3):e1005961. doi: 10.1371/journal.pgen.1005961. eCollection 2016.
- During central nervous system (CNS) development neural stem cells (Neuroblasts, NBs) have to acquire an identity appropriate to their location. In thoracic and abdominal segments of Drosophila, the expression pattern of Bithorax-Complex Hox genes is known to specify the segmental identity of NBs pri
- PMID 27015425
- Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex.
- Savitsky M1, Kim M2, Kravchuk O3, Schwartz YB4.
- Genetics.Genetics.2016 Feb;202(2):601-17. doi: 10.1534/genetics.115.179309. Epub 2015 Dec 29.
- Chromatin insulators are remarkable regulatory elements that can bring distant genomic sites together and block unscheduled enhancer-promoter communications. Insulators act via associated insulator proteins of two classes: sequence-specific DNA binding factors and "bridging" proteins. The latter are
- PMID 26715665
Japanese Journal
- Mapping Polycombrepressed domains in the bithorax complex using in vivo formaldehyde cross-inked chromatin
- Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin
- Trithorax regulates multiple homeotic genes in the bithorax and antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each.
Related Links
- bithorax definition from the mondofacto online medical dictionary ... Search dictionary help bithorax medical dictionary A group of genes (at least nine) found in the fruit fly genus Drosophila which codes for proper segmenting of the thorax ...
- Bithorax The ancestral (left) and melanic (right) form of the peppered moth. The backgrounds are non-polluted bark (upper drawing) and polluted bark (lower drawing). Biston betularia bithorax a gene residing ... ... Bithorax The ...
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