- 関
- bioactivity
WordNet
- any specific behavior; "they avoided all recreational activity"
- (chemistry) the capacity of a substance to take part in a chemical reaction; "catalytic activity"
- of parents and children; related by blood; "biological child"
- pertaining to biology or to life and living things (同)biologic
PrepTutorEJDIC
- 〈U〉『活動』,働き;活力 / 《しばしば複数形で》(種々の)『活動』,行事;(学生の)学内(外)活動,クラブ活動 / 〈U〉(商況・市場などの)活発,活気
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/18 21:31:43」(JST)
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In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.[1][2] When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or pharmacophore but can be modified by the other constituents. Among the various properties of chemical compounds, pharmacological/biological activity plays a crucial role since it suggests uses of the compounds in the medical applications. However, chemical compounds may show some adverse and toxic effects which may prevent their use in medical practice.
Activity is generally dosage-dependent. Further, it is common to have effects ranging from beneficial to adverse for one substance when going from low to high doses. Activity depends critically on fulfillment of the ADME criteria. To be an effective drug, a compound not only must be active against a target, but also possess the appropriate ADME (Absorption, Distribution, Metabolism, and Excretion) properties necessary to make it suitable for use as a drug.[3]
Whereas a material is considered bioactive if it has interaction with or effect on any cell tissue in the human body, pharmacological activity is usually taken to describe beneficial effects, i.e. the effects of drug candidates as well as a substance's toxicity.
In the study of biomineralisation, bioactivity is often meant as the formation of calcium phosphate deposits on the surface of objects placed in simulated body fluid, a buffer solution with ion content similar to blood.
See also
- Lipinski's Rule of Five, describing molecular properties of drugs
- QSAR, quantitative structure-activity relationship
- Chemical property
- Molecular property
- Physical property
- Chemical structure
References
- ^ Etymology: Gk, bios, life; L, activus, with energy, Mosby's Medical Dictionary, 8th edition. © 2009, Elsevier.
- ^ Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc.
- ^ A.Jagan Mohan Reddy, Manas Ranjan Barik,Gajendra L. Muli and Parthasarathy.T (2012). "Computational Approach for Designing and Development of Potent Inhibitor for Hepatitis - B Virus X- Associated Protein through Molecular Docking Studies". Journal of Chemical and Pharmaceutical Research 4 (1): 265–271.
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English Journal
- Utilization of Leek (Allium ampeloprasum var. porrum) for Inulinase Production.
- Tasar OC1, Erdal S, Algur OF.
- Preparative biochemistry & biotechnology.Prep Biochem Biotechnol.2015 Aug 18;45(6):596-604. doi: 10.1080/10826068.2014.940538.
- Inulinase production by Rhodotorula glutinis was carried out in this study, using leek (Allium ampeloprasum var. porrum) as an alternative carbon source due to its high inulin content and easy availability. Taguchi orthogonal array (OA) design of experiment (DOE) was used to optimize fermentation co
- PMID 25036570
- Sugar ester surfactants: enzymatic synthesis and applications in food industry.
- Neta NS1, Teixeira JA, Rodrigues LR.
- Critical reviews in food science and nutrition.Crit Rev Food Sci Nutr.2015 Apr 16;55(5):595-610. doi: 10.1080/10408398.2012.667461.
- Sugar esters are non-ionic surfactants that can be synthesized in a single enzymatic reaction step using lipases. The stability and efficiency of lipases under unusual conditions and using non-conventional media can be significantly improved through immobilization and protein engineering. Also, the
- PMID 24915370
- Physicochemical characterisation of four cherry species (Prunus spp.) grown in China.
- Cao J1, Jiang Q1, Lin J1, Li X1, Sun C2, Chen K1.
- Food chemistry.Food Chem.2015 Apr 15;173:855-63. doi: 10.1016/j.foodchem.2014.10.094. Epub 2014 Oct 25.
- The physicochemical characteristics of four cherry species (Prunus avium, Prunus cerasus, Prunus pseudocerasus and Prunus tomentosa) were evaluated. Inter-species variability was greater than intra-species differences. Glucose and fructose were the main sugars, and malic acid was the main organic ac
- PMID 25466099
Japanese Journal
- Anticancer Activity of Pristimerin in Epidermal Growth Factor Receptor 2-Positive SKBR3 Human Breast Cancer Cells
- Percutaneous Absorption and Antibacterial Activities of Lipid Nanocarriers Loaded with Dual Drugs for Acne Treatment
- One Pot Synthesis and Biological Activity Evaluation of Novel Schiff Bases Derived from 2-Hydrazinyl-1,3,4-thiadiazole
- Haj Mohammad Ebrahim Tehrani Kamaleddin,Sardari Soroush,Mashayekhi Vida
- Chemical and pharmaceutical bulletin 61(2), 160-166, 2013-02
- NAID 40019558565
Related Links
- Definition of BIOLOGICAL ACTIVITY in the Definitions.net dictionary. Meaning of BIOLOGICAL ACTIVITY. What does BIOLOGICAL ACTIVITY mean? Information and translations of BIOLOGICAL ACTIVITY in the most comprehensive ...
- Among the topics are lectins with varying specificity and biological activity from marine bivalves, biological activities of proteins and marine-derived peptides from byproducts and seaweeds, producing lactobacilli proteinases for ...
Related Pictures
★リンクテーブル★
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- 英
- biological activity、bioactivity
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- 生理活性、生物学的活性、生命活動
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- bioactive、biological activity
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- 英
- biological activity
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- 生物活性、生物学的活性
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- 英
- biological activity
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- 生物活性、生命活動
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- biol、biologic、biologically、biology、biotic、flesh、organism
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- biol、biological、biologically、biology、biotic、flesh、organism
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- active