UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. メニエール病 meniere disease
2. 前庭片頭痛 vestibular migraine
3. 良性発作性頭位めまい症 benign paroxysmal positional vertigo
4. 回転性めまいの治療 treatment of vertigo
5. 内視鏡的逆行性胆管膵管造影（ERCP）後膵炎 post endoscopic retrograde cholangiopancreatography ercp pancreatitis

English Journal

Label-free versus conventional cellular assays: Functional investigations on the human histamine H1 receptor.

Lieb S1, Littmann T1, Plank N1, Felixberger J1, Tanaka M2, Schäfer T3, Krief S4, Elz S1, Friedland K3, Bernhardt G1, Wegener J5, Ozawa T2, Buschauer A6.
Pharmacological research.Pharmacol Res.2016 Oct 15;114:13-26. doi: 10.1016/j.phrs.2016.10.010. [Epub ahead of print]
A set of histamine H1 receptor (H1R) agonists and antagonists was characterized in functional assays, using dynamic mass redistribution (DMR), electric cell-substrate impedance sensing (ECIS) and various signaling pathway specific readouts (Fura-2 and aequorin calcium assays, arrestin recruitment (l
PMID 27751876

Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.

Tang KT1, Chao YH2, Chen DY1, Lim YP3, Chen YM1, Li YR2, Yang DH4, Lin CC5.
International immunopharmacology.Int Immunopharmacol.2016 Oct;39:236-45. doi: 10.1016/j.intimp.2016.07.030. Epub 2016 Aug 3.
The objective of this study was to evaluate the potential therapeutic effects of betahistine dihydrochloride (betahistine) in a collagen-induced arthritis (CIA) mouse model. CIA was induced in DBA/1 male mice by primary immunization with 100μl of emulsion containing 2mg/ml chicken type II collagen
PMID 27494687

An LC-MS/MS assay for the quantitative determination of 2-pyridyl acetic acid, a major metabolite and key surrogate for betahistine, using low-volume human K2 EDTA plasma.

Soni K1, Bhatt C1, Singh K1, Bhuvaneshwari PC1, Jha A1, Patel P1, Patel H1, Srinivas NR1.
Biomedical chromatography : BMC.Biomed Chromatogr.2016 Jul 18. doi: 10.1002/bmc.3790. [Epub ahead of print]
Betahistine is widely used for the treatment of vertigo. Owing to first-pass metabolism, 2-pyridyl acetic acid (2PAA, major metabolite of betahistine) was considered as surrogate for quantitation. A specific and sensitive LC-MS/MS method was developed and validated for quantitation of 2PAA using tur
PMID 27428039

新井基洋,五島史行,保坂隆
心身医学 52(3), 221-228, 2012-03-01
… ーションと補中益気湯を併用しQOLの改善効果を検討した.対象は入院治療前にSelf-rating Depression Scale(以下,SDS)検査を施行し,抑うつ傾向(50>SDS≧40)を呈する患者275例である.全例にめまい薬物治療(betahistine mesilateおよびATP製剤の内服)と集団めまいリハビリテーションを施行し,補中益気湯投与群は入院期間中から前記治療に加えて本剤を併用した.結果:投与群,非投与群ともにQOLの改善が認められた.また両 …
NAID 110009418965

新井基洋,五島史行,保坂隆
心身医学 51(10), 919-926, 2011-10-01
… ションとSSRIの併用療法によるQOLの改善内容を明らかにする目的で,入院時のSDS検査におけるスコアが50以上の患者を対象としたレトロスペクティブな検討を行った.めまい治療は,薬物治療としてbetahistine mesilate(メリスロン^[○!R])18mg/日とATP製剤(10%アデホス顆粒^[○!R])3g/日の内服とし,さらに集団めまいリハビリテーション併用加療を施行した.また,うつ状態の治療にはSSRIのfluvoxamine(デプロメール^[○!R])5 …
NAID 110008722825

新井基洋,五島史行,保坂隆
心身医学 51(5), 416-423, 2011-05-01
… スペクティブな検討を行った.対象は入院治療前にSDS検査を全例施行し,SDS≧50をうつ状態群,50>SDS≧40を抑うつ傾向群,40>SDSを正常群の3群に分けて検討した.治療は全例にめまい薬物治療としてbetahistine mesilate(メリスロン^[○!R])18mg/日とATP製剤(10%アデホス顆粒^[○!R])3g/日の内服と集団めまいリハビリテーション併用加療を施行した.うつ状態群は入院期間中から前記治療にさらにfluvoxamine(デプロメール^ …
NAID 110008607729