関: alpha-secretase、amyloid precursor protein secretase、BACE、beta-site APP cleaving enzyme、gamma-secretase、secretase

WordNet

to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
spend or use time; "I may be an hour"
stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
the act of gambling; "he did it on a bet" (同)wager
maintain with or as if with a bet; "I bet she will be there!" (同)wager
second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
the 2nd letter of the Greek alphabet
preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimers)
beets (同)genus Beta

PrepTutorEJDIC

《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/15 14:51:15」(JST)

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1. アミロイドーシスの概要overview of amyloidosis [show details]
…the much larger amyloid precursor protein (APP) by secretases that are specific for its amino (beta-secretase) and carboxy (gamma-secretase) terminal residues. The role of amyloid in Alzheimer disease is…
2. アルツハイマー病の疫学、病理、および病因epidemiology pathology and pathogenesis of alzheimer disease [show details]
…cleavage of mature protein translated from the amyloid precursor protein (APP) gene and cleaved by beta-secretase and gamma-secretase. Presenilin forms part of the gamma-secretase complex, and mutations in presenilin…
3. 認知症の予防prevention of dementia [show details]
4. アミロイド疾患の遺伝的要因genetic factors in the amyloid diseases [show details]

English Journal

Structural insight into the mechanism of amyloid precursor protein recognition by β-secretase 1: A molecular dynamics study.

Chakraborty S1, Basu S2.
Biophysical chemistry.Biophys Chem.2015 Jul;202:1-12. doi: 10.1016/j.bpc.2015.03.006. Epub 2015 Mar 25.
β-secretase 1 (BACE1) initiates the proteolysis of amyloid precursor protein (APP) to generate Aβ, aggregation of which has been considered to be the main histopathological feature of Alzheimer's Disease. Here, we have explored the conformational switching of BACE1 during APP recognition using mol
PMID 25863345

APLP1 promotes dFoxO-dependent cell death in Drosophila.

Wang X1, Ma Y, Zhao Y, Chen Y, Hu Y, Chen C, Shao Y, Xue L.
Apoptosis : an international journal on programmed cell death.Apoptosis.2015 Jun;20(6):778-86. doi: 10.1007/s10495-015-1097-1.
The amyloid precursor like protein-1 (APLP1) belongs to the amyloid precursor protein family that also includes the amyloid precursor protein (APP) and the amyloid precursor like protein-2 (APLP2). Though the three proteins share similar structures and undergo the same cleavage processing by α-, β
PMID 25740230

Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp.

Takahashi R1, Ma S, Yue Q, Kim-Kang H, Yi Y, Lyssikatos JP, Regal K, Hunt KW, Kallan NC, Siu M, Hop CE, Liu X, Khojasteh SC.
European journal of drug metabolism and pharmacokinetics.Eur J Drug Metab Pharmacokinet.2015 Jun;40(2):171-85. doi: 10.1007/s13318-014-0198-5. Epub 2014 Apr 3.
(R)-2-Amino-1,3',3'-trimethyl-7'-(pyrimidin-5-yl)-3',4'-dihydro-2'H-spiro[imidazole-4,1'-naphthalen]-5(1H)-one (GNE-892) is an orally administered inhibitor of β-secretase 1 (β-site amyloid precursor protein cleaving enzyme 1, BACE1) that was developed as an intervention therapy against Alzheimer'
PMID 24696325

Japanese Journal

ダウン症患者における早期アルツハイマー病発症メカニズムの解明

浅井将,川久保昂,森亮太郎,岩田修永
薬学雑誌. 乙号 137(7), 801-805, 2017
… It has been considered for a number of years that 1.5-fold expression of the gene for the amyloid precursor protein (APP) located on chromosome 21 leading to overproduction of amyloid-β … peptide (Aβ) results in the early onset of AD in adults with DS. … However, the mean age of onset of familial AD with the Swedish mutation on APP which has high affinity for β-secretase associated with a dramatic increase in Aβ …
NAID 130007287823

組換えβ-secretase産生系の構築とセクレターゼ活性測定法への応用

白石有希,小池あゆみ,山村晃,飯田泰広
神奈川工科大学研究報告.B,理工学編 (38), 79-84, 2014-03-20
… In AD case, the insoluble amyloid is produced by β and γ secretase by catalyzing the amyloid precursor peptide. … All the β-secretase inhibitors are substrate analogs, it means that those are competitive and reversible inhibitor. … We have developed new methods which can evaluate irreversible enzyme inhibitors easily by flow injection analysis (FIA) system in combination with immobilized enzyme and we would like to apply the β- secretase to the system for evaluation of irreversible agents. …
NAID 120005436454

組換えβ-secretase産生系の構築とセクレターゼ活性測定法への応用

白石有希,小池あゆみ,山村晃 [他]
神奈川工科大学研究報告. A・B, 人文社会科学編・理工学編 Research reports of Kanagawa Institute of Technology. 神奈川工科大学編 (38), 79-84, 2014
NAID 40020037547

Related Pictures

Alpha- and beta-secretase - Ludwig-Maximilians-Universität, Chair of Metabolic BACE Implicated in Alzheimer's Amyloid Production: R&D Systems Amyloid Precursor Protein Secretases; alpha-Secretase; beta-Secretase; gamma-Secretase Frontiers | Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Beta Secretase Activity Assay Kit (Fluorometric) (ab65357) Beta-secretase 1 Frontiers | β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer

★リンクテーブル★

リンク元	「βセクレターゼ」「amyloid precursor protein secretase」「BACE」「alpha-secretase」「beta-site APP cleaving enzyme」
関連記事	「secreta」「beta」「be」