関: benidipine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/30 06:00:55」(JST)

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Benidipine (INN), also known as Benidipinum or benidipine hydrochloride, is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension).

Dosing [edit]

Benidipine is dosed as 2–4 mg once daily.^[1]

Availability [edit]

Benidipine is sold as Coniel by Kyowa Hakko Kogyo.

Benidipine is only licensed for use in Japan and selected Southeast Asian countries, where it is sold as 4 mg tablets.

References [edit]

^ Hi-Eisai Pharmaceutical, Inc. "Coniel (benidipine) package insert (Philippines)". MIMS Philippines. CMPMedica. Retrieved 2008-03-31. Text " Molecular Weight 542.03" ignored (help)

English Journal

Recurrent Extracranial Internal Carotid Artery Vasospasm Diagnosed by Serial Magnetic Resonance Angiography and Superselective Transarterial Injection of a Calcium Channel Blocker.

Shimoda Y1, Fujimura M2, Kimura N3, Ezura M3, Uenohara H3, Tominaga T4.Author information 1Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurosurgery, National Hospital Organization Sendai Medical Center, Sendai, Japan.2Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurosurgery, National Hospital Organization Sendai Medical Center, Sendai, Japan. Electronic address: mfujimur@gmail.com.3Department of Neurosurgery, National Hospital Organization Sendai Medical Center, Sendai, Japan.4Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.AbstractRecurrent vasospasm of the extracranial internal carotid artery (ICA) is extremely rare, and optimal management is unclear. A 25-year-old woman developed transient dysarthria and left-sided hemiparesis. Initial magnetic resonance (MR) imaging showed spotty acute infarction in the right temporal lobe, and MR angiography revealed right ICA occlusion. ICA occlusion was spontaneously resolved within 6 days of its onset, whereas transient left ICA narrowing was evident at 12 days. Because recurrent occlusion of the right ICA occurred at 14 days when the contralateral ICA was still narrowed, we attempted a local intra-arterial injection of a calcium channel blocker based on the diagnosis of recurrent extracranial ICA vasospasm. The local injection of 1 mg of nicardipine partially dilated the affected ICA, which confirmed the diagnosis of vasospasm. After the introduction of oral medication with benidipine hydrochloride, bilateral ICA vasospasm was completely resolved 23 days after its onset, as shown by MR angiography. In conclusion, we recommend intensive radiologic follow-up at the acute stage and therapeutic catheter angiography when the bilateral lesion is evident because bilateral occlusion of the ICA could lead to a catastrophic condition.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.J Stroke Cerebrovasc Dis.2014 Mar 18. pii: S1052-3057(14)00003-2. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.050. [Epub ahead of print]
Recurrent vasospasm of the extracranial internal carotid artery (ICA) is extremely rare, and optimal management is unclear. A 25-year-old woman developed transient dysarthria and left-sided hemiparesis. Initial magnetic resonance (MR) imaging showed spotty acute infarction in the right temporal lobe
PMID 24656242

Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells.

Choi NY1, Choi H2, Park HH2, Lee EH1, Yu HJ3, Lee KY2, Joo Lee Y2, Koh SH4.Author information 1Department of Neurology, Hanyang University College of Medicine, Seoul, Republic of Korea; Department of Translational Medicine, Hanyang University Graduate School of Biomedical Science & Engineering, Seoul, Republic of Korea.2Department of Neurology, Hanyang University College of Medicine, Seoul, Republic of Korea.3Department of Neurology, Bundang Jesaeng Hospital, Gyeonggi Province, Republic of Korea.4Department of Neurology, Hanyang University College of Medicine, Seoul, Republic of Korea; Department of Translational Medicine, Hanyang University Graduate School of Biomedical Science & Engineering, Seoul, Republic of Korea. Electronic address: ksh213@hanyang.ac.kr.AbstractHypertension is associated with oxidative stress. Amlodipine besylate (AB) and benidipine hydrochloride (BH), which are Ca(2+) antagonists, have been reported to reduce oxidative stress. In this study, we examined the neuroprotective effects of AB and BH on oxidative stress-injured neural stem cells (NSCs), with a focus on the phosphatidylinositol 3-kinase (PI3K) pathway and the extracellular signal-regulated kinase (ERK) pathway. After treatment with H2O2, the viability of NSCs decreased in a concentration-dependent manner; however, co-treatment with AB or BH restored the viability of H2O2-injured NSCs. H2O2 increased free radical production and apoptosis in NSCs, whereas co-treatment with AB or BH attenuated these effects. To evaluate the effects of AB or BH on the H2O2-inhibited proliferation of NSCs, we performed BrdU labeling and colony formation assays and found that NSC proliferation decreased upon H2O2 treatment but that combined treatment with AB or BH restored this proliferation. Western blot analysis showed that AB and BH increased the expression of cell survival-related proteins that were linked with the PI3K and ERK pathways but decreased the expression of cell death-related proteins. To investigate whether the PI3K and ERK pathways were directly involved in the neuroprotective effects of AB and BH on H2O2-treated NSCs, NSCs were pretreated with the PI3K inhibitor, LY294002, or the ERK inhibitor, FR180204, which significantly blocked the effects of AB and BH. Together, our results suggest that AB and BH restore the H2O2-inhibited viability and proliferation of NSCs by inhibiting oxidative stress and by activating the PI3K and ERK pathways.
Brain research.Brain Res.2014 Mar 10;1551:1-12. doi: 10.1016/j.brainres.2014.01.016. Epub 2014 Jan 16.
Hypertension is associated with oxidative stress. Amlodipine besylate (AB) and benidipine hydrochloride (BH), which are Ca(2+) antagonists, have been reported to reduce oxidative stress. In this study, we examined the neuroprotective effects of AB and BH on oxidative stress-injured neural stem cells
PMID 24440775

Effects of the antihypertensive drug benidipine on osteoblast function in vitro.

Wang B1, Bi M2, Zhu Z3, Wu L1, Wang J1.Author information 1Department of Prosthodontics, School of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China.2Department of Comprehensive Treatment, School of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China.3Department of Prosthodontics, Zhenjiang Stomatological Hospital, Zhenjiang, Jiangsu 212002, P.R. China.AbstractThe dihydropyridine-type calcium channel blocker, benidipine (BD) has been widely used in hypertension therapy. Previous studies have demonstrated that BD has a positive effect on bone metabolism. Inspired by this promoting phenomenon, the present study investigated the effects of BD on osteoblasts in vitro. Experiments were designed and performed, including an MTT assay, reverse transcription-polymerase chain reaction, western blot analysis, alkaline phosphatase activity measurements and alizarin red S staining. The results demonstrated that BD promoted osteoblast proliferation and osteogenic differentiation at concentrations from 1×10-6 to 1×10-9 M by upregulating Runx2, BMP2 and OCN gene expression levels. Overall, BD at appropriate concentrations has been demonstrated to have positive effects on osteoblast function in addition to its conventional clinical usage.
Experimental and therapeutic medicine.Exp Ther Med.2014 Mar;7(3):649-653. Epub 2014 Jan 3.
The dihydropyridine-type calcium channel blocker, benidipine (BD) has been widely used in hypertension therapy. Previous studies have demonstrated that BD has a positive effect on bone metabolism. Inspired by this promoting phenomenon, the present study investigated the effects of BD on osteoblasts
PMID 24520261

Japanese Journal

本態性高血圧患者のアンジオテンシン受容体遮断薬に対するべニジピンの追加投与が、スケーリング係数に及ぼす影響について

市丸みどり,市丸みどり
東京女子医科大学雑誌 83(2), 95-105, 2013-04-25
目的:アンジオテンシン受容体遮断薬とカルシウム拮抗薬の併用による降圧効果の機序について、DFA(Detrended Fluctuation Analysis)より得られるスケーリング指標を用いて判定した。,対象と方法:カルシウム拮抗薬およびアンジオテンシン受容体遮断薬との併用療法の有用性を研究することを目的としたJ-SUCCESS(Study of the Usefulness of Combin …
NAID 110009581136

Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice

Ohtani Keisuke,Usui Soichiro,Kaneko Shuichi,Takashima Shin-ichiro,Kitano Katsunori,Yamamoto Kanako,Okajima Masaki,Furusho Hiroshi,Takamura Masayuki
Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 35(3), 287-294, 2012-03-01
… Benidipine, a long-acting T-and L-type calcium channel blocker, reduces infarct size following myocardial I/R in rabbits. … Benidipine also inhibits the production of aldosterone in vitro. … Benidipine was administered orally at 3 mg kg -1daily for 3 weeks without any changes in hemodynamic variables. … Benidipine significantly reduced infarction size (13.4±2.5%) compared with controls (25.5±3.6%). …
NAID 10030644313

薬局薬剤師による心電図モニタリング：塩酸ドネペジル服用に伴い延長した　ＱＴｃが相互作用薬の変更により短縮した一例

篠崎幸喜
YAKUGAKU ZASSHI 132(2), 237-241, 2012
… Case: An 80-year-old woman was under donepezil (5 mg/d) therapy for Alzheimer's disease and also taking other drugs that interact with donepezil, namely, benidipine (8 mg/d) and atorvastatin (10 mg/d). … Her doctor was informed about these results and the risk factors (advanced age, gender, and drugs interactions (benidipine and atorvastatin)) associated with TdP and asked to respond promptly since several cases of donepezil-induced TdP have been reported. …
NAID 130001872015

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★リンクテーブル★

リンク元	「ベニジピン」
拡張検索	「benidipine hydrochloride」

「ベニジピン」

Benidipine
Systematic (IUPAC) name
	O5-methyl O3-[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	105979-17-7
ATC code	C08CA15
PubChem	CID 656668
ChemSpider	571013
UNII	4G9T91JS7E
Chemical data
Formula	C28H31N3O6
	SMILES [O-][N+](=O)c1cccc(c1)[C@@H]4C(/C(=O)OC)=C(\N\C(=C4\C(=O)O[C@@H]3CCCN(Cc2ccccc2)C3)C)C;
	InChI InChI=1S/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1; Key:QZVNQOLPLYWLHQ-ZEQKJWHPSA-N ;
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