WordNet

staining readily with basic dyes
a leukocyte with basophilic granules easily stained by basic stains (同)basophile
a nucleated cell in bone marrow from which red blood cells develop

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1. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
2. 成人における全身性エリテマトーデスの血液学的異常 hematologic manifestations of systemic lupus erythematosus in adults
3. 好中球減少症における感染の原因 infectious causes of neutropenia
4. アレルギーのin vitro検査の概要 overview of in vitro allergy tests
5. 鉄芽球性貧血の病態生理 pathophysiology of the sideroblastic anemias

English Journal

The co-repressor Rcor1 is essential for murine erythropoiesis.

Yao H1, Goldman DC, Nechiporuk T, Kawane S, McWeeney SK, Tyner JW, Fan G, Kerenyi MA, Orkin SH, Fleming WH, Mandel G.Author information 1Vollum Institute, Howard Hughes Medical Institute, Oregon Health & Science University, Portland, OR, United States;AbstractThe co-repressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophilic erythroblast. Remarkably, Rcor1 null erythroid progenitors cultured in vitro form myeloid colonies instead of erythroid colonies. The mutant proerythroblasts also aberrantly express genes of the myeloid lineage as well as genes typical of hematopoietic stem cell (HSC) / progenitor cells. The Colony Stimulating Factor 2 Receptor Beta subunit (Csf2rb) which codes for a receptor implicated in myeloid cytokine signaling is a direct target for both Rcor1 and the transcription repressor Gfi1b in erythroid cells. In the absence of Rcor1, the Csf2rb gene is highly induced, and Rcor1-/- progenitors exhibit CSF2-dependent phospho-Stat5 hypersensitivity. Blocking this pathway can partially reduce myeloid colony formation by Rcor1-deficient erythroid progenitors. Thus, Rcor1 promotes erythropoiesis by repressing HSC/progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
Blood.Blood.2014 Mar 20. [Epub ahead of print]
The co-repressor Rcor1 has been linked biochemically to hematopoiesis, but its function in vivo remains unknown. We show that mice deleted for Rcor1 are profoundly anemic and die in late gestation. Definitive erythroid cells from mutant mice arrest at the transition from proerythroblast to basophili
PMID 24652990

Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis.

Satchwell TJ1, Pellegrin S, Bianchi P, Hawley BR, Gampel A, Mordue KE, Budnik A, Fermo E, Barcellini W, Stephens DJ, van den Akker E, Toye AM.Author information 1ash.m.toye@bristol.ac.uk.AbstractCongenital dyserythropoietic anemia type II is an autosomally recessive form of hereditary anemia caused by SEC23B gene mutations. Patients exhibit characteristic phenotypes including multinucleate erythroblasts, erythrocytes with hypoglycosylated membrane proteins and an apparent double plasma membrane. Despite ubiquitous expression of SEC23B, the effects of mutations in this gene are confined to the erythroid lineage and the basis of this erythroid specificity remains to be defined. In addition, little is known regarding the stage at which the disparate phenotypes of this disease manifest during erythropoiesis. We employ an in vitro culture system to monitor the appearance of the defining phenotypes associated with congenital dyserythropoietic anemia type II during terminal differentiation of erythroblasts derived from small volumes of patient peripheral blood. Membrane protein hypoglycosylation was detected by the basophilic stage, preceding the onset of multinuclearity in orthochromatic erythroblasts that occurs coincident with the loss of secretory pathway proteins including SEC23A during erythropoiesis. Endoplasmic reticulum remnants were observed in nascent reticulocytes of both diseased and healthy donor cultures but were lost upon further maturation of normal reticulocytes, implicating a defect of ER clearance during reticulocyte maturation in congenital dyserythropoietic anemia type II. We also demonstrate distinct isoform and species-specific expression profiles of SEC23 during terminal erythroid differentiation and identify a prolonged expression of SEC23A in murine erythropoiesis compared to humans. We propose that SEC23A is able to compensate for the absence of SEC23B in mouse erythroblasts, providing a basis for the absence of phenotype within the erythroid lineage of a recently described SEC23B knockout mouse.
Haematologica.Haematologica.2013 Nov;98(11):1788-96. doi: 10.3324/haematol.2013.085522. Epub 2013 Aug 9.
Congenital dyserythropoietic anemia type II is an autosomally recessive form of hereditary anemia caused by SEC23B gene mutations. Patients exhibit characteristic phenotypes including multinucleate erythroblasts, erythrocytes with hypoglycosylated membrane proteins and an apparent double plasma memb
PMID 23935019

Immunophenotypic profile of nucleated erythroid progenitors during maturation in regenerating bone marrow.

Fajtova M1, Kovarikova A, Svec P, Kankuri E, Sedlak J.Author information 1Cancer Research Institute.AbstractThis study introduces an in-depth flow cytometric method for the analysis of nucleated erythroid progenitors during bone marrow regeneration. Initial immunophenotypic analysis with the conventional erythroid-associated markers CD36, CD71 and CD235a was supplemented with the analysis of additional markers, including CD105, CD117, CD45, CD38 and cell-scattered light characteristics. Our data show that the expression of CD105 and CD117 is critical for the distinction between four phenotypically different developmental stages of nucleated erythroid progenitors: pro-erythroblasts, basophilic erythroblasts, polychromatophilic erythroblasts and orthochromatophilic erythroblasts. CD105 antigen expression was specifically associated with pro-erythroblasts and basophilic erythroblasts, whereas CD117 was expressed at the earliest pro-erythroblast stage. Both antigens were progressively lost throughout the course of differentiation. These data allow for the identification of aberrant erythroid development in acute erythroid leukemia or myelodysplastic syndrome.
Leukemia & lymphoma.Leuk Lymphoma.2013 Nov;54(11):2523-30. doi: 10.3109/10428194.2013.781167. Epub 2013 Apr 23.
This study introduces an in-depth flow cytometric method for the analysis of nucleated erythroid progenitors during bone marrow regeneration. Initial immunophenotypic analysis with the conventional erythroid-associated markers CD36, CD71 and CD235a was supplemented with the analysis of additional ma
PMID 23452116

Japanese Journal

Erythropoiesis and thrombopoiesis in the head-kidney of the sea bass (Dicentrarchus labrax L.): An ultrastructural study.

, , ,
Archives of Histology and Cytology 52(4), 407-419, 1989
… Erythropoiesis consists of a proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, acidophilic erythroblast, young erythrocyte and old erythrocyte, the latter being nucleated and without nuclear vacuolation. …
NAID 130004780082

Erythropoiesis and thrombopoiesis in the head-kidney of the sea bass (Dicentrarchus labrax L.): An ultrastructural study.

ESTEBAN M. A.,MESEGUER J.,AYALA A. GARCIA,AGULLEIRO B.
Ａｒｃｈｉｖｅｓ　ｏｆ　Ｈｉｓｔｏｌｏｇｙ　ａｎｄ　Ｃｙｔｏｌｏｇｙ 52(4), 407-419, 1989
… Erythropoiesis consists of a proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, acidophilic erythroblast, young erythrocyte and old erythrocyte, the latter being nucleated and without nuclear vacuolation. …
NAID 130003423711

骨髄性白血病における赤芽球増殖動態の検討

小野垣義男
北関東医学 26(5), 373-385, 1976
… There was a significant, positive correlation between ERC activity and relative erythroblast counts in the bone marrow. … LI in the basophilic erythroblasts remained within normal range, while the decrease in LI was conspicuous and statistically significant in polychromatic erythroblasts. …
NAID 130003689705

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