アゾセミド
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/09/02 16:37:23」(JST)
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Azosemide
|
Systematic (IUPAC) name |
2-chloro-5-(2H-tetrazol-5-yl)-4-[(thiophen-2-ylmethyl)amino]benzenesulfonamide |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
CAS number |
27589-33-9 N |
ATC code |
? |
PubChem |
CID 2273 |
ChemSpider |
2186 Y |
UNII |
MR40VT1L8Z Y |
KEGG |
D01323 Y |
ChEBI |
CHEBI:31248 Y |
ChEMBL |
CHEMBL1097235 Y |
Chemical data |
Formula |
C12H11ClN6O2S2 |
Mol. mass |
370.84 g/mol |
SMILES
- O=S(=O)(N)c2c(Cl)cc(c(c1nnnn1)c2)NCc3sccc3
|
InChI
-
InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19) Y
Key:HMEDEBAJARCKCT-UHFFFAOYSA-N Y
|
N (what is this?) (verify)
|
Azosemide is a high-ceiling diuretic agent.
Synthesis
References
Popelak, A.; Lerch, A.; Stach, K.; Roesch, E.; Hardebeck, K.; German Offen., 1970, 815922; Chem. Abstr. 1970, 73, 45519.
English Journal
- Comparative analysis of the therapeutic effects of long-acting and short-acting loop diuretics in the treatment of chronic heart failure using (123)I-metaiodobenzylguanidine scintigraphy.
- Hisatake S, Nanjo S, Fujimoto S, Yamashina S, Yuzawa H, Namiki A, Nakano H, Yamazaki J.SourceDepartment of Cardiovascular Medicine, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Ota-ku, Tokyo 143-8541, Japan. s-hisata@td5.so-net.ne.jp
- European journal of heart failure.Eur J Heart Fail.2011 Aug;13(8):892-8. Epub 2011 May 20.
- AIMS: Loop diuretics are essential for the treatment of chronic heart failure (CHF) but short-acting diuretics are reported to induce sympathetic nervous system (SNS) activation. This study was performed to compare therapeutic effects of two loop diuretics, long-acting azosemide and short-acting fur
- PMID 21602550
- Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide.
- Harada K, Izawa H, Nishizawa T, Hirashiki A, Murase Y, Kobayashi M, Isobe S, Cheng XW, Noda A, Nagata K, Yokota M, Murohara T.SourceDepartment of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. haraken@med.nagoya-u.ac.jp
- Journal of cardiovascular pharmacology.J Cardiovasc Pharmacol.2009 Jun;53(6):468-73.
- Loop diuretics could adversely influence prognosis due to activation of neurohumoral mechanism in the long term. Previous study showed torasemide, a loop diuretic with anti-aldosteronergic properties, was associated with lower mortality in patients with chronic heart failure (CHF). We evaluated the
- PMID 19430310
- Assessment of diuretic effects and changes in plasma aldosterone concentration following oral administration of a single dose of furosemide or azosemide in healthy dogs.
- Hori Y, Katou A, Tsubaki M, Kanai K, Nakao R, Hoshi F, Itoh N, Higuchi S.SourceDepartment of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.
- American journal of veterinary research.Am J Vet Res.2008 Dec;69(12):1664-9.
- OBJECTIVE: To determine the diuretic effects and changes in plasma aldosterone concentration (PAC) following oral administration of a single dose of furosemide or azosemide in healthy dogs.ANIMALS: 8 mixed-breed dogs.PROCEDURES: A single dose of furosemide (2 mg/kg), azosemide (1, 5, or 10 mg/kg), o
- PMID 19046016
Japanese Journal
- 慢性腎臓病患者における長時間作用型と短時間作用型ループ利尿薬の効果と安全性の検討
- 駒田 敬則,吉田 泉,佐久間 由紀,森 穂波,雨宮 守正,中里 優一,田部井 薫
- 自治医科大学紀要 33, 79-90, 2011-03-01
- 現在ループ利尿薬を服用している血清Cr値1.5mg/dl以上の外来患者を対象とし,文書にて同意を得られた34名を対象とした。投与薬剤の順番をランダム化して,アゾセミドまたはフロセミドを,1-2ヶ月毎に交互に投与した。その結果,アゾセミド60mgとフロセミド40mgを同等力価と考えて交互に投与した場合,血圧,体重,尿量,尿中Na排泄量に差はなく,血液検査データ,尿中電解質などにも差は無かった。尿蛋白 …
- NAID 110008506955
- 慢性腎臓病患者における長時間作用型と短時間作用型ループ利尿薬の効果と安全性の検討
- Rationale and Design of a Randomized Trial to Assess the Effects of Diuretics in Heart Failure : Japanese Multicenter Evaluation of Long- vs Short-Acting Diuretics in Congestive Heart Failure(J-MELODIC)
- The J-MELODIC Program Committee
- Circulation journal : official journal of the Japanese Circulation Society 71(7), 1137-1140, 2007-06-20
- … The present study was designed to compare the therapeutic effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting one, in patients with HF to test the hypothesis that long-acting diuretics are superior therapy. …
- NAID 110006318418
Related Links
- アゾセミド(Azosemide)の検索ならお薬検索QLife(キューライフ)。お医者さんが処方する処方薬と、薬局で買える市販薬(OTC)、の効果と副作用、写真、添付文書、保管方法等を掲載。商品名だけでなく一般名や剤形、色などからも検索 ...
- ROCKY NOTE http://rockymuku.sakura.ne.jp/ROCKYNOTE.html ROCKY NOTE http://rockymuku.sakura.ne.jp/ROCKYNOTE.html azosemideとfurosemideはどちらの効果が優れるか(120816) 当初azosemide(ダイアート®)だけが ...
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★リンクテーブル★
[★]
- 英
- azosemide
- 商
- アゾセリック、ダイアート、ダイタリック
- 関
- 利尿薬、ループ利尿薬
- 健康成人では経口投与後1時間以内に作用が発現し、9時間後まで持続((株)三和化学研究所 社内資料(薬物動態に関する資料))。
- 浮腫患者においては12時間後まで作用が持続した(山田和生 他:基礎と臨床 18(9):4471,1984)。