アラキドン酸12-リ・キシゲナーゼ
- 関
- 12-lipoxygenase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/03 01:01:43」(JST)
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arachidonate 12-lipoxygenase |
Identifiers |
EC number |
1.13.11.31 |
CAS number |
82391-43-3 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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Arachidonate 12-lipoxygenase (EC 1.13.11.31) is an enzyme that catalyzes the chemical reaction
- arachidonate + O2 (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Thus, the two substrates of this enzyme are arachidonate and oxygen, whereas its product is (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is arachidonate:oxygen 12-oxidoreductase. Other names in common use include Delta12-lipoxygenase, 12-lipoxygenase, 12Delta-lipoxygenase, C-12 lipoxygenase, 12S-lipoxygenase, leukotriene A4 synthase, and LTA4 synthase. This enzyme participates in arachidonic acid metabolism. At least one compound, 3-methoxytropolone is known to inhibit this enzyme.
References
- Hamberg M, Samuelsson B (1974). "Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets". Proc. Natl. Acad. Sci. U.S.A. 71 (9): 3400–4. doi:10.1073/pnas.71.9.3400. PMC 433780. PMID 4215079.
- Nugteren DH (1975). "Arachidonate lipoxygenase in blood platelets". Biochim. Biophys. Acta 380 (2): 299–307. doi:10.1016/0005-2760(75)90016-8. PMID 804329.
- Wallach DP, Brown VR (1981). "A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases". Biochim. Biophys. Acta 663 (2): 361–72. doi:10.1016/0005-2760(81)90165-x. PMID 6783111.
Leukotriene signaling
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Receptor
(ligands) |
BLT |
BLT1
|
- Agonists: 12-HETE
- 20-Hydroxy-LTB4
- Leukotriene B4
- LY-255283
- Antagonists: 20-Carboxy-LTB4
- Amelubant
- CGS-23131 (LY-223982)
- CGS-25019C
- CP-105696
- CP-195543
- Etalocib
- LY-293111
- Moxilubant
- ONO-4057
- RG-14893
- RP-69698
- SB-209247
- SC-53228
- Ticolubant
- U-75302
- ZK-158252
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BLT2
|
- Agonists: 12-HETE
- 12-HHT
- 12-HpETE
- 15-HETE
- 15-HpETE
- 20-Hydroxy-LTB4
- Leukotriene B4
- Antagonists: CP-195543
- LY-255283
- ZK-158252
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CysLT |
CysLT1
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- Agonists: Leukotriene C4
- Leukotriene D4
- Leukotriene E4
- Antagonists: Ablukast
- BAYu9773
- BAYu9916
- BAYx7195
- Cinalukast
- FPL-55712
- ICI-198615
- Iralukast
- LY-170680
- Masilukast
- MK-571
- Montelukast
- ONO-1078
- Pobilukast
- Pranlukast
- Ritolukast
- SKF-104353
- SR-2640
- Sulukast
- Tipelukast
- Tomelukast
- Verlukast
- Zafirlukast
- ZD-3523
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CysLT2
|
- Agonists: Leukotriene C4
- Leukotriene D4
- Leukotriene E4
- Antagonists: BAYu9773
- BAYu9916
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CysLTE
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Enzyme
(inhibitors) |
5-Lipoxygenase |
- 2-TEDC
- Baicalein
- BW-A4C
- BW-B70C
- Caffeic acid
- CDC
- CJ-13610
- Curcumin
- Hyperforin
- Hypericum perforatum (St. John's Wort)
- Meclofenamic acid (meclofenamate)
- Minocycline
- N-Stearoyldopamine
- Timegadine
- Zileuton
- FLAP inhibitors: AM-103
- AM-679
- BAYx1005
- MK-591
- MK-886
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12-Lipoxygenase |
- 2-TEDC
- 3-Methoxytropolone
- Baicalein
- CDC
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15-Lipoxygenase |
- 2-TEDC
- CDC
- Luteolin
- PD-146176
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LTA4 hydrolase |
- Captopril
- DG-051
- Fosinoprilat
- JNJ-26993135
- SA-6541
- SC-57461A
- Ubenimex (bestatin)
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LTB4 ω-hydroxylase |
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LTC4 synthase |
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LTC4 hydrolase |
- Acivicin
- Serine-borate complex
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LTD4 hydrolase |
- Cilastatin
- Ubenimex (bestatin)
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Others |
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- 5-HPETE (arachidonic acid 5-hydroperoxide)
- Leukotriene A4
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See also: Prostanoids
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Oxidoreductases: monooxygenases (EC 1.13)
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1.13.11: two atoms of oxygen |
- lipoxygenase: Arachidonate 5-lipoxygenase
- Arachidonate 12-lipoxygenase/ALOX12
- Arachidonate 8-lipoxygenase
- Arachidonate 15-lipoxygenase/ALOX15
- Linoleate 11-lipoxygenase
- other dioxygenase: Catechol dioxygenase
- Homogentisate 1,2-dioxygenase
- Cysteine dioxygenase
- 4-Hydroxyphenylpyruvate dioxygenase
- Indoleamine 2,3-dioxygenase
- Chlorite dismutase
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1.13.12: one atom of oxygen |
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1.13.99: other |
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Proteins: enzymes
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- Radiosensitivity of human prostate cancer cells can be modulated by inhibition of 12-lipoxygenase.
- Lövey J, Nie D, Tóvári J, Kenessey I, Tímár J, Kandouz M, Honn KV.SourceDepartments of Radiotherapy and Experimental Therapeutics, National Institute of Oncology, Budapest, Hungary.
- Cancer letters.Cancer Lett.2013 Jul 28;335(2):495-501. doi: 10.1016/j.canlet.2013.03.012. Epub 2013 Mar 21.
- Nearly 30% of prostate cancer (PCa) patients treated with potentially curative doses relapse at the sites of irradiation. How some tumor cells acquire radioresistance is poorly understood. The platelet-type 12-lipoxygenases (12-LOX)-mediated arachidonic acid metabolism is important in PCa progressio
- PMID 23523613
- The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.
- Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA, Serhan CN.Source1C.N.S., Harvard Institutes of Medicine, 77 Ave. Louis Pasteur, HIM 829, Boston, MA 02115, USA. cnserhan@zeus.bwh.harvard.edu.
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2013 Jul;27(7):2573-83. doi: 10.1096/fj.13-227728. Epub 2013 Mar 15.
- Maresins are produced by macrophages from docosahexaenoic acid (DHA) and exert potent proresolving and tissue homeostatic actions. Maresin 1 (MaR1; 7R,14S-dihydroxy-docosa-4Z,8E,10E,12Z,16Z,19Z-hexaenoic acid) is the first identified maresin. Here, we investigate formation, stereochemistry, and prec
- PMID 23504711
- 12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival.
- Weisinger G, Grafi-Cohen M, Hirsh M, Knoll E, Sharon O, Many A, Limor R, Stern N.SourceInstitute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel. gary_w@tasmc.health.gov.il
- Experimental cell research.Exp Cell Res.2013 Jun 10;319(10):1586-93. doi: 10.1016/j.yexcr.2013.04.001. Epub 2013 Apr 8.
- Considerable evidence has been published demonstrating the importance of lipoxygenase enzymes for vascular smooth muscle cell (VSMC) growth. The current study sets out to determine whether or not 12-lipoxygenase (12LO) is also important for human placental VSMC survival. Both a pharmacological and t
- PMID 23578768
Japanese Journal
- Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase
- Hinokitiol, a selective inhibitor of the platelet-type isozyme of arachidonate 12-lipoxygenase
- Platelet-type Arachidonate 12-Lipoxygenase in Mouse Gastrointestinal Tract
- , ,
- Acta histochemica et cytochemica 31(1), 71-75, 1998
- … 12-Lipoxygenase enzyme oxygenates the position 12 of arachidonic acid, and produces 12S-hydroperoxy-arachidonic acid. … When mouse gastrointestinal tract was immunostained with an antiserum against human platelet 12-lipoxygenase and examined by light microscopy, positively-stained cells were found in the epithelium of stomach and small and large intestines. …
- NAID 110003146810
Related Links
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★リンクテーブル★
[★]
- 英
- arachidonate 12-lipoxygenase
- 関
- 12-リポキシゲナーゼ
[★]
アラキドン酸、アラキドン酸エステル
- 関
- AA、arachidonic acid
[★]
リポキシゲナーゼ, 不飽和脂肪酸酸化酵素, LOX