12-リポキシゲナーゼ
- 同
- 152
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/19 15:40:12」(JST)
[Wiki en表示]
arachidonate 12-lipoxygenase |
Identifiers |
EC number |
1.13.11.31 |
CAS number |
82391-43-3 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
Arachidonate 12-lipoxygenase (EC 1.13.11.31) is an enzyme that catalyzes the chemical reaction
- arachidonate + O2 (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Thus, the two substrates of this enzyme are arachidonate and oxygen, whereas its product is (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is arachidonate:oxygen 12-oxidoreductase. Other names in common use include Delta12-lipoxygenase, 12-lipoxygenase, 12Delta-lipoxygenase, C-12 lipoxygenase, 12S-lipoxygenase, leukotriene A4 synthase, and LTA4 synthase. This enzyme participates in arachidonic acid metabolism. At least one compound, 3-methoxytropolone is known to inhibit this enzyme.
References
- Hamberg M, Samuelsson B (1974). "Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets". Proc. Natl. Acad. Sci. U.S.A. 71 (9): 3400–4. doi:10.1073/pnas.71.9.3400. PMC 433780. PMID 4215079.
- Nugteren DH (1975). "Arachidonate lipoxygenase in blood platelets". Biochim. Biophys. Acta. 380 (2): 299–307. doi:10.1016/0005-2760(75)90016-8. PMID 804329.
- Wallach DP, Brown VR (1981). "A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases". Biochim. Biophys. Acta. 663 (2): 361–72. doi:10.1016/0005-2760(81)90165-x. PMID 6783111.
Oxidoreductases: monooxygenases (EC 1.13)
|
|
1.13.11: two atoms of oxygen |
- lipoxygenase: Arachidonate 5-lipoxygenase
- Arachidonate 12-lipoxygenase/ALOX12
- Arachidonate 8-lipoxygenase
- Arachidonate 15-lipoxygenase/ALOX15
- Linoleate 11-lipoxygenase
- other dioxygenase: Catechol dioxygenase
- Homogentisate 1,2-dioxygenase
- Cysteine dioxygenase
- 4-Hydroxyphenylpyruvate dioxygenase
- Indoleamine 2,3-dioxygenase
|
|
1.13.12: one atom of oxygen |
|
|
1.13.99: other |
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
Leukotriene signaling
|
|
Receptor
(ligands) |
BLT |
BLT1
|
- Agonists: 12-HETE
- 20-Hydroxy-LTB4
- Leukotriene B4
- LY-255283
- Antagonists: 20-Carboxy-LTB4
- Amelubant
- CGS-23131 (LY-223982)
- CGS-25019C
- CP-105696
- CP-195543
- Etalocib
- LY-293111
- Moxilubant
- ONO-4057
- RG-14893
- RP-69698
- SB-209247
- SC-53228
- Ticolubant
- U-75302
- ZK-158252
|
|
BLT2
|
- Agonists: 12-HETE
- 12-HHT
- 12-HpETE
- 15-HETE
- 15-HpETE
- 20-Hydroxy-LTB4
- Leukotriene B4
- Antagonists: CP-195543
- LY-255283
- ZK-158252
|
|
|
CysLT |
CysLT1
|
- Agonists: Leukotriene C4
- Leukotriene D4
- Leukotriene E4
- Antagonists: Ablukast
- BAYu9773
- BAYu9916
- BAYx7195
- Cinalukast
- FPL-55712
- ICI-198615
- Iralukast
- LY-170680
- Masilukast
- MK-571
- Montelukast
- ONO-1078
- Pobilukast
- Pranlukast
- Ritolukast
- SKF-104353
- SR-2640
- Sulukast
- Tipelukast
- Tomelukast
- Verlukast
- Zafirlukast
- ZD-3523
|
|
CysLT2
|
- Agonists: Leukotriene C4
- Leukotriene D4
- Leukotriene E4
- Antagonists: BAYu9773
- BAYu9916
|
|
CysLTE
|
|
|
|
|
Enzyme
(inhibitors) |
5-Lipoxygenase |
- 2-TEDC
- Baicalein
- BW-A4C
- BW-B70C
- Caffeic acid
- CDC
- CJ-13610
- Curcumin
- Hyperforin
- Hypericum perforatum (St. John's Wort)
- Meclofenamic acid (meclofenamate)
- Minocycline
- N-Stearoyldopamine
- Timegadine
- Zileuton
- FLAP inhibitors: AM-103
- AM-679
- BAYx1005
- MK-591
- MK-886
|
|
12-Lipoxygenase |
- 2-TEDC
- 3-Methoxytropolone
- Baicalein
- CDC
|
|
15-Lipoxygenase |
- 2-TEDC
- CDC
- Luteolin
- PD-146176
|
|
LTA4 hydrolase |
- Captopril
- DG-051
- Fosinoprilat
- JNJ-26993135
- SA-6541
- SC-57461A
- Ubenimex (bestatin)
|
|
LTB4 ω-hydroxylase |
|
|
LTC4 synthase |
|
|
LTC4 hydrolase |
- Acivicin
- Serine-borate complex
|
|
LTD4 hydrolase |
- Cilastatin
- Ubenimex (bestatin)
|
|
|
Others |
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- 5-HPETE (arachidonic acid 5-hydroperoxide)
- Leukotriene A4
|
|
See also: Prostanoids
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.
- Li S, Zhao X, Wu Z, Li Y, Zhu L, Cui B, Dong X, Tian S, Hu F, Zhao Y.SourceDepartment of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, People's Republic of China.
- Familial cancer.Fam Cancer.2013 Dec;12(4):755-65. doi: 10.1007/s10689-013-9659-2.
- Cyclooxygenase-2 (COX-2), 12-lipoxygenase (12-LOX) and phospholipaseA2 (PLA2) played important roles in the modulation of apoptosis, angiogenesis, carcinogenesis and invasion of colorectal cancer (CRC). The polymorphisms in COX-2, 12-LOX and PLA2 may affect their roles. Therefore, we investigated if
- PMID 23715757
- Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase-Dependent Inflammation.
- Bhowmick R, Tin Maung NH, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM.SourceDepartment of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111;
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2013 Nov 15;191(10):5115-23. doi: 10.4049/jimmunol.1300522. Epub 2013 Oct 2.
- Acute pulmonary infection by Streptococcus pneumoniae is characterized by high bacterial numbers in the lung, a robust alveolar influx of polymorphonuclear cells (PMNs), and a risk of systemic spread of the bacterium. We investigated host mediators of S. pneumoniae-induced PMN migration and the role
- PMID 24089193
- Development of a new colorimetric assay for lipoxygenase activity.
- Lu W, Zhao X, Xu Z, Dong N, Zou S, Shen X, Huang J.SourceShanghai Key Laboratory of New Drug Design, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
- Analytical biochemistry.Anal Biochem.2013 Oct 15;441(2):162-8. doi: 10.1016/j.ab.2013.06.007. Epub 2013 Jun 26.
- Lipoxygenases (LOXs) are a family of non-heme iron-containing dioxygenases that catalyze the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. A rapid and reliable colorimetric assay for determination of the activity of three human functional lipoxygenase isoforms (5-lipoxy
- PMID 23811155
Japanese Journal
- Comparison of 12-lipoxygenase expression in vascular smooth muscle cells from old normotensive Wistar-Kyoto rats with spontaneously hypertensive rats
- KIM Hye Young,JEONG Dae Won,PARK Ho Sun,LEE Tae Yoon,KIM Hee Sun
- Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 36(1), 65-73, 2013-01-01
- NAID 10031163287
- アラキドン酸12-リポキシゲナーゼによって誘発された酸化ストレスと炎症は,糖尿病性心筋症の発症を促進する (第129回成医会総会一般演題)
- 鈴木 博史,坂本 昌也,香山 洋介,井内 裕之,東條 克能,吉村 道博,宇都宮 一典
- 東京慈恵会医科大学雑誌 127(6), 236-236, 2012-11-15
- NAID 120005104551
- Angiotensin II inhibits chemokine CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats
- YUN Young Hyun,KIM Hye Young,DO Byung Soo,KIM Hee Sun
- Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 34(12), 1313-1320, 2011-12-01
- NAID 10030278057
Related Links
- 12-Lipoxygenase inhibitor 12リポキシゲナーゼ阻害剤 15-Lipoxygenase inhibitor 15リポキシゲナーゼ阻害剤 3-Ketosteroid reductase inhibitor 3ケトステロイド-還元酵素阻害剤 5-alpha-reductase inhibitor 5-Alpha-還元酵素阻害剤 5 ...
- Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S ...
Related Pictures
★リンクテーブル★
[★]
アラキドン酸12-リ・キシゲナーゼ
- 関
- 12-lipoxygenase
[★]
リポキシゲナーゼ, 不飽和脂肪酸酸化酵素, LOX