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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/01 06:24:05」(JST)
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Aprindine
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Systematic (IUPAC) name |
{3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Identifiers |
CAS Number |
37640-71-4 Y |
ATC code |
C01BB04 |
PubChem |
CID: 2218 |
DrugBank |
DB01429 Y |
ChemSpider |
2132 Y |
UNII |
5Y48085P9Q Y |
KEGG |
D02969 Y |
ChEMBL |
CHEMBL1213033 Y |
Chemical data |
Formula |
C22H30N2 |
Molecular mass |
322.487 g/mol |
SMILES
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c1cccc3c1CC(N(c2ccccc2)CCCN(CC)CC)C3
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InChI
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InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3 Y
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Key:NZLBHDRPUJLHCE-UHFFFAOYSA-N Y
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Y (what is this?) (verify) |
Aprindine is a Class 1b antiarrhythmic agent.[1]
In one study, it delayed atrial fibrillation more than digoxin did.[2]
It has shown effectiveness when given orally.[3]
References
- ^ Sato R, Hisatome I, Tanaka Y; et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
- ^ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation". Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271. [dead link]
- ^ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.
Antiarrhythmic agents (C01B)
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Channel blockers |
class I
(Na+ channel blockers)
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class Ia (Phase 0→ and Phase 3→)
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- Ajmaline
- Disopyramide
- Lorajmine
- Prajmaline
- Procainamide#
- Quinidine#
- Sparteine
|
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class Ib (Phase 3←)
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- IV (Lidocaine#)
- enteral (Aprindine
- Mexiletine
- Tocainide)
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class Ic (Phase 0→)
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- Encainide‡
- Ethacizine
- Flecainide
- Indecainide‡
- Lorcainide
- Moracizine‡
- Propafenone
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|
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class III
(Phase 3→, K+ channel blockers)
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- Amiodarone
- Bretylium
- Bunaftine
- Dofetilide
- Dronedarone
- E-4031†
- Ibutilide
- Nifekalant
- Sotalol
- Tedisamil
- Vernakalant
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|
class IV
(Phase 4→, Ca2+ channel blockers)
|
|
|
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Receptor agonists
and antagonists |
class II
(Phase 4→, β blockers)
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- Nadolol
- Pindolol
- Propranolol
- cardioselective (Acebutolol
- Atenolol
- Esmolol
- Metoprolol)
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A1 agonist
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- Adenosine
- Benzodiazepines
- Barbiturates
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M2
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- muscarinic antagonist: Atropine
- Disopyramide
- Quinidine
muscarinic agonist: Digoxin
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α receptors
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- Amiodarone
- Bretylium
- Quinidine
- Verapamil
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Ion transporters |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of the heart
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Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Injury
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
- Blood tests
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|
Treatment |
- Procedures
- Drugs
- glycosides
- other stimulants
- antiarrhythmics
- vasodilators
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English Journal
- Enantioselective plasma protein binding of propafenone: mechanism, drug interaction, and species difference.
- Hong Y, Tang Y, Zeng S.SourceDepartment of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
- Chirality.Chirality.2009 Jul;21(7):692-8. doi: 10.1002/chir.20666.
- The interaction of propafenone (PPF) enantiomers with human plasma, human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), as well as with plasma from rat, rabbit, and cow was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques. The s
- PMID 18937289
- Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current.
- Tamura A, Ogura T, Uemura H, Reien Y, Kishimoto T, Nagai T, Komuro I, Miyazaki M, Nakaya H.SourceDepartment of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan.
- Journal of pharmacological sciences.J Pharmacol Sci.2009 Jun;110(2):150-9. Epub 2009 Jun 5.
- After the report of the Cardiac Arrhythmia Suppression Trial, a tabular framework of the Sicilian Gambit has been proposed to display actions of antiarrhythmic drugs on ion channels and receptors and to provide more rational pharmacotherapy of arrhythmias. However, because effects of antiarrhythmic
- PMID 19498275
- Relationship between serum aprindine concentration and neurologic side effects in Japanese.
- Tsuchishita Y, Fukumoto K, Kusumoto M, Ueno K.SourceDepartment of Pharmacy, Maizuru Kyosai Hospital, Federation of National Public Services and Affiliated Mutual Associations, Japan.
- Biological & pharmaceutical bulletin.Biol Pharm Bull.2009 Apr;32(4):637-9.
- The aim of this study was to evaluate the relationship between the neurologic side effects associated with serum aprindine concentrations and the safety range of aprindine for the prevention of neurologic side effects in 142 Japanese inpatients. Serum aprindine concentrations were determined by high
- PMID 19336897
Japanese Journal
- Effects of Antiarrhythmic Drugs on the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Current
- TAMURA Atsushi,OGURA Takehiko,UEMURA Hiroko,REIEN Yoshie,KISHIMOTO Takashi,NAGAI Toshio,KOMURO Issei,MIYAZAKI Masaru,NAKAYA Haruaki
- Journal of pharmacological sciences 110(2), 150-159, 2009-06-20
- … The inhibitory effects of quinidine, disopyramide, cibenzoline, lidocaine, mexiletine, aprindine, propafenone, flecainide, propranolol, and verapamil on the HCN4 channel current were weak in their therapeutic concentrations, with IC50 values of 78.3, 249, 46.8, 276, 309, 43.7, 14.3, 1700, 50.5, and 44.9 μM, respectively, suggesting that the inhibitory effects on If would be clinically small. …
- NAID 10025737030
- Relationship between Serum Aprindine Concentration and Neurologic Side Effects in Japanese(Pharmacology)
- TSUCHISHITA Yoshimasa,FUKUMOTO Kyoko,KUSUMOTO Masaaki,UENO Kazuyuki
- Biological & pharmaceutical bulletin 32(4), 637-639, 2009-04-01
- … The aim of this study was to evaluate the relationship between the neurologic side effects associated with serum aprindine concentrations and the safety range of aprindine for the prevention of neurologic side effects in 142 Japanese inpatients. … Serum aprindine concentrations were determined by high-performance liquid chromatography. …
- NAID 110007160658
Related Links
- References: Sato R, Hisatome I, Tanaka Y, Sasaki N, Kotake H, Mashiba H, Katori R: Aprindine blocks the sodium current in guinea-pig ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol. 1991 Sep;344(3):331-6. Pubmed ...
- 研究 Disopyramide, Aprindine, Mexiletineによる頻度依存性心房間伝導時間延長の検討:伝導遅延の発現および回復過程の相違について The frequency dependent interatrial conduction delay by disopyramide, aprindine and mexiletine in ...
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- 英
- aprindine
- 化
- 塩酸アプリンジン aprindine hydrochloride
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- 関
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