WordNet

any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
any of a group of enzymes (occurring especially in plant cells) that catalyze the oxidation of a compound by a peroxide
having the effect of counteracting excessive thyroid activity; "antithyroid drugs"

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抗体,免疫体,抗毒素

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1. 橋本病（慢性自己免疫性甲状腺炎）の病因 pathogenesis of hashimotos thyroiditis chronic autoimmune thyroiditis
2. 妊娠していない成人における甲状腺機能低下症の診断およびスクリーニング diagnosis of and screening for hypothyroidism in nonpregnant adults
3. 妊娠中の甲状腺疾患の概要 overview of thyroid disease in pregnancy
4. 妊娠中の甲状腺機能低下症：臨床症状、診断、および治療 hypothyroidism during pregnancy clinical manifestations diagnosis and treatment
5. 甲状腺機能低下症の原因となる疾患 disorders that cause hypothyroidism

English Journal

Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?

Muller I1, Giani C, Zhang L, Grennan-Jones FA, Fiore E, Belardi V, Rosellini V, Funel N, Campani D, Giustarini E, Lewis MD, Bakhsh AD, Roncella M, Ghilli M, Vitti P, Dayan CM, Ludgate ME.Author information 1Thyroid Research Group Institute of Molecular & Experimental Medicine School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom; Department of Endocrinology, University of Pisa, Pisa, Italy.AbstractWomen with breast cancer (BC) and antithyroid peroxidase (TPO) autoantibodies (TPOAb) have a better prognosis than women lacking TPOAb. Sera from women with TPOAb displayed immunoreactivity to BC tissue by immunofluorescence that was not apparent in women without TPOAb. We hypothesize a BC/thyroid shared antigen that provides a target for humoral or cell-mediated immune activity; candidates include the sodium/iodide symporter (expressed in thyroid and BC), cross-reacting epitopes in TPO and lactoperoxidase (LPO) or TPO itself. As the association is with TPOAb, we investigated TPO expression in BC, breast peritumoral tissue (PT), other tissues (tumoral and not) and thyroid as positive control. Transcripts for known and novel TPO isoforms were detected in BC (n = 8) and PT (n = 8) but at approximately 10(4) -fold lower than in thyroid while in non-BC tumors (n = 5) they were at the limit of detection. TPO was expressed also in adipose tissue (n = 17), 10(3) -fold lower than in thyroid. Full length TPO (Mr 105-110 kDa) was detected in Western blots in the majority of examined tissues; preabsorption of the TPO antibody with recombinant TPO (but not LPO) reduced the signal, indicating specificity. The same occurred with some lower molecular weight bands, which could correspond to smaller TPO transcript isoforms, present in all samples. In conclusion, TPO is weakly expressed in BC and other tissues; this could partly explain the high frequency and protective role of TPOAb in BC patients. Further studies will investigate tissue specificity, function and immunogenicity of the novel TPO variants (some BC-specific) identified.
International journal of cancer. Journal international du cancer.Int J Cancer.2014 Apr 1;134(7):1706-14. doi: 10.1002/ijc.28493. Epub 2013 Oct 15.
Women with breast cancer (BC) and antithyroid peroxidase (TPO) autoantibodies (TPOAb) have a better prognosis than women lacking TPOAb. Sera from women with TPOAb displayed immunoreactivity to BC tissue by immunofluorescence that was not apparent in women without TPOAb. We hypothesize a BC/thyroid s
PMID 24114667

Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) in childhood.

Patnaik SK, Upreti V, Dhull P.AbstractAbstract Aim: Steroid responsive encephalopathy with autoimmune thyroiditis (SREAT) is a clinically and electrographically heterogeneous steroid-responsive encephalopathy associated with thyroid autoantibodies. We report an adolescent with SREAT and review PubMed literature relating to childhood. Methods: A 14-year-old boy, without any preceding history of trauma, meningoencephalitis or seizures, was admitted in a comatose state. A similar episode of loss of consciousness 2 months prior with normal neuroimaging and electroencephalogram (EEG) had been followed by behavioral alterations. A year previously, during evaluation for increased appetite and poor weight gain, he was noted to have small goitre with thyroid-stimulating hormone (TSH) 7.26 mIU/L, T3 1.232 nmol/L, and T4 117.63 nmol/L. Routine hemogram, blood biochemistry, thyroid function tests including free hormone levels, ultrasonography thyroid and magnetic resonance imaging were normal. EEG showed diffuse slowing of all waves. Cerebrospinal fluid showed no pleocytosis and electrophoresis showed oligoclonal band. Viral studies and serum N-methyl-D-aspartate receptor antibody levels were negative. Anti-thyroid peroxidase (Anti-TPO) antibodies were raised. Intervention was with intravenous dexamethasone 4 mg every 6 h for 1 week followed by tapering schedule of oral prednisolone over 6 months. Results: He regained consciousness after the second dose of dexamethasone and was discharged on day 7 in a fully conscious and ambulant state on a tapering course of low dose prednisolone for 6 months. He remains euthyroid with normal sensorium and behavior at 18 months follow-up. Only 50 cases below 18 years age were identified amongst 300 PubMed articles up to 31 July 2013. Conclusion: Prompt steroid therapy following early recognition by high clinical suspicion and measurement of antithyroid antibody titers can lead to a favorable prognosis in SREAT.
Journal of pediatric endocrinology & metabolism : JPEM.J Pediatr Endocrinol Metab.2014 Mar 6. pii: /j/jpem-ahead-of-print/jpem-2013-0435/jpem-2013-0435.xml. doi: 10.1515/jpem-2013-0435. [Epub ahead of print]
Abstract Aim: Steroid responsive encephalopathy with autoimmune thyroiditis (SREAT) is a clinically and electrographically heterogeneous steroid-responsive encephalopathy associated with thyroid autoantibodies. We report an adolescent with SREAT and review PubMed literature relating to childhood. Me
PMID 24598831

Low Levels of Serum Vitamin D3 are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women.

Choi YM1, Kim WG, Kim TY, Bae SJ, Kim HK, Jang EK, Jeon MJ, Han JM, Lee SH, Baek JH, Shong YK, Kim WB.Author information 11 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Korea.AbstractBackground: Low serum vitamin D levels have been associated with several autoimmune diseases, but their association with thyroid autoimmunity is unclear. We evaluated the association of serum vitamin D levels with the prevalence of autoimmune thyroid disease (AITD). Methods: Our cross-sectional study included subjects who underwent routine health checkups, which included assays of serum 25-hydroxy vitamin D3 (25(OH)D3) and antithyroid peroxidase antibody (TPO-Ab), as well as thyroid ultrasonography (US) between 2008 and 2012 at the Asan Medical Center. We defined AITD according to the levels of TPO-Ab and US findings. Results: A total of 6685 subjects (58% male; 42% female) were enrolled for this study. Overall prevalence of TPO-Ab positivity and both TPO-Ab/US positivity were 10.1% (6.3% male; 15.3% female) and 5.4% (2.3% male; 9.7% female) respectively. In female subjects, mean serum 25(OH)D3 levels were significantly lower in the TPO-Ab(+) (22.0 vs. 23.5 ng/mL, p=0.030) and TPO-Ab(+)/US(+) groups (21.6 vs. 23.4 ng/mL, p=0.027) compared with the control group, respectively. According to the levels of serum 25(OH)D3, the prevalence of TPO-Ab positivity (21.2%, 15.5%, and 12.6% in deficient, insufficient, and sufficient group, respectively; p=0.001) and both TPO-Ab and US positivity (14.7%, 9.9%, and 7.1% in deficient, insufficient, and sufficient group, respectively; p<0.001) decreased in female subjects. Interestingly, this pattern was significant only in pre-menopausal women (p=0.003 and p<0.001; respectively), but not in postmenopausal women. Multivariate analysis indicated that the adjusted odds ratios (OR) for AITD among those in the 25(OH)D3-deficient (TPO-Ab(+): OR 1.95, p=0.001; TPO-Ab(+)/US(+): OR 2.36, p<0.001) and -insufficient groups (TPO-Ab(+): OR 1.31, p=0.043; TPO-Ab(+)/US(+): OR 1.50, p=0.017) were significantly increased when compared with the sufficient group. Conclusions: The levels of serum vitamin D were significantly lower in pre-menopausal women with AITD. Vitamin D deficiency and insufficiency were significantly associated with AITD in pre-menopausal women.
Thyroid : official journal of the American Thyroid Association.Thyroid.2014 Jan 30. [Epub ahead of print]
Background: Low serum vitamin D levels have been associated with several autoimmune diseases, but their association with thyroid autoimmunity is unclear. We evaluated the association of serum vitamin D levels with the prevalence of autoimmune thyroid disease (AITD). Methods: Our cross-sectional stud
PMID 24320141

Japanese Journal

甲状腺機能異常を伴うC型慢性肝炎に対するペグインターフェロン・リバビリン併用療法

岡野美紀,奥瀬千晃,四柳宏,島順子,服部伸洋,重福隆太,野口陽平,初谷守朗,中原一有,池田裕喜,高橋秀明,松永光太郎,松本伸行,石井俊哉,佐藤明,福田安伸,小池和彦,鈴木通博,伊東文生
肝臓 54(11), 731-740, 2013
ペグインターフェロン・リバビリン併用療法（併用療法）開始時に遊離トリヨードサイロニン，遊離サイロキシンおよび甲状腺刺激ホルモンが測定され，甲状腺機能異常（TD）を認めたC型慢性肝炎（CHC）12例を対象にTDを伴うCHCに対する併用療法の詳細を検討した．潜在性甲状腺機能低下症が4例，顕性甲状腺機能低下症が4例，潜在性甲状腺機能亢進症が4例であった．抗甲状腺ペルオキシダーゼ抗体（TPO Ab）が陽性 …
NAID 130003384482

Risk for Progression to Overt Hypothyroidism in an Elderly Japanese Population with Subclinical Hypothyroidism

Imaizumi Misa,Sera Nobuko,Ueki Ikuko,Horie Ichiro,Ando Takao,Usa Toshiro,Ichimaru Shinichiro,Nakashima Eiji,Hida Ayumi,Soda Midori,Tominaga Tan,Ashizawa Kiyoto,Maeda Renju,Nagataki Shigenobu,Akahoshi Masazumi
Thyroid 21(11), 1177-1182, 2011-11-03
… Higher baseline TSH levels were associated with progression from subclinical to overt hypothyroidism (p=0.02) in the multivariate analysis, including age, sex, antithyroid peroxidase antibody, and ultrasonography (US) findings. …
NAID 120003751872

Prevalence of Thyroid Autoantibodies in Hepatitis C and Hepatits B Infection in China

Yang Rong,Shan Zhongyan,Li Yushu,Fan Chenling,Li Chenyang,Teng Weiping
Internal Medicine 50(8), 811-815, 2011
… Methods We collected 462 samples with positive thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TgAb). … A third-generation enzymelinked immunosorbent assay (ELISA) was used to examine the presence of anti-HCV antibody. … We also examined RNA HCV expression of subjects with positive anti-HCV antibody. …
NAID 130000650069