- 関
- antiemesis、antiemetic agent、antiemetic drug、antiemetics
- 関
- specific agen ts
WordNet
- a drug that prevents or alleviates nausea and vomiting (同)antiemetic_drug
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/05 22:15:40」(JST)
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An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer. They may be used for severe cases of gastroenteritis, especially if the patient is dehydrated.
Antiemetics, though previously thought to cause birth defects, have been proven safe for use by pregnant women in the treatment of morning sickness and the more serious hyperemesis gravidarum.[1][2]
Contents
- 1 Types of antiemetics
- 2 References
- 3 See also
Types of antiemetics
Antiemetics include:
- 5-HT3 receptor antagonists block serotonin receptors in the central nervous system and gastrointestinal tract. As such, they can be used to treat post-operative and cytotoxic drug nausea & vomiting. However, they can also cause constipation or diarrhea, dry mouth, and fatigue.[3]
- Dolasetron (Anzemet) can be administered in tablet form or in an injection.
- Granisetron (Kytril, Sancuso) can be administered in tablet (Kytril), oral solution (Kytril), injection D(Kytril), or in a single transdermal patch to the upper arm (SANCUSO).
- Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, or in an IV/IM injection.
- Tropisetron (Setrovel, Navoban) can be administered in oral capsules or in injection form.
- Palonosetron (Aloxi) can be administered in an injection or in oral capsules.
- Mirtazapine (Remeron) is an antidepressant that also has antiemetic effects[4][5] and is also a potent histamine H1 receptor antagonist, Ki=1.6 nM.[6]
- Dopamine antagonists act in the brain and are used to treat nausea and vomiting associated with neoplastic disease, radiation sickness, opioids, cytotoxic drugs and general anaesthetics. Side effects include muscle spasms and restlessness.[3]
- Domperidone (Motilium)
- Olanzapine (Zyprexa)
- Droperidol, haloperidol, chlorpromazine, prochlorperazine. Some of these drugs are limited in their usefulness by their extra-pyramidal and sedative side-effects.
- Alizapride
- Prochlorperazine (Compazine, Stemzine, Buccastem, Stemetil, Phenotil)
- Metoclopramide (Reglan) also acts on the GI tract as a pro-kinetic, and is thus useful in gastrointestinal disease; however, it is poor in cytotoxic or post-op vomiting. also a 5-HT3 receptor antagonists
- NK1 receptor antagonist
- Aprepitant (Emend) is a commercially available NK1 Receptor antagonist
- Casopitant is an investigational NK1 receptor antagonist
- Antihistamines (H1 histamine receptor antagonists) are effective in many conditions, including motion sickness, morning sickness in pregnancy, and to combat opioid nausea.
- Cyclizine
- Diphenhydramine (Benadryl)
- Dimenhydrinate (Gravol, Dramamine)
- Doxylamine
- Meclizine (Bonine, Antivert)
- Promethazine (Pentazine, Phenergan, Promacot) can be administered via a rectal suppository for adults and children over 2 years of age.
- Hydroxyzine (Vistaril)
- Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These may cause changes in perception, dizziness, and loss of coordination.[3]
- Cannabis, also known as medical marijuana in the United States, is a Schedule I drug.[citation needed]
- Dronabinol (Marinol) is a Schedule III drug in the U.S.[citation needed]
- Some synthetic cannabinoids such as Nabilone (Cesamet) or the JWH series.
- Sativex is an oral spray containing THC and CBD. It is currently legal in Canada and a few countries in Europe but not legal in the U.S.[citation needed]
- Benzodiazepines
- Midazolam is given at the onset of anesthesia has been shown in recent trials to be as effective as ondansetron.[citation needed]
- Lorazepam (Ativan) is said to be very good as an adjunct treatment for nausea along with first line medications such as Compazine or Zofran.[citation needed]
- Anticholinergics
- Hyoscine (also known as scopolamine)
- Steroids
- Dexamethasone (Decadron) is given in low dose at the onset of a general anaesthetic is an effective antiemetic. The specific mechanism of action is not fully understood.[citation needed]
- Other
- Trimethobenzamide is thought to work on the CTZ
- Ginger contains 5-HT3 antagonists gingerols, shogaols,[7] and galanolactone.[8] Preliminary clinical data suggests ginger may be effective for treatment of nausea and/or vomiting in a number of settings.[9][10]
- Emetrol is also claimed to be an effective antiemetic.
- Propofol is given intravenously. It has been used in an acute care setting in hospital as a rescue therapy for emesis.[citation needed]
- Peppermint is claimed to help nausea or stomach pain when added into a tea or peppermint candies.
- Muscimol is purported to have antiemetic activity.[11]
- Ajwain is purported to be antiemetic. It is a popular spice in India, Ethiopia and Eritrea.[citation needed]
References
- ^ Quinlan, Jeffrey D.; Hill, D. Ashley (1 June 2003). "Nausea and Vomiting in Pregnancy - American Family Physician". American Family Physician 68 (1): 121–128. Retrieved 2015-10-09.
- ^ Schaefer, Christof; Scialli, Anthony; Rost van Tonningen, Margreet (2001). "Antiemetics and hyperemesis gravidarum". Drugs During Pregnancy and Lactation: Handbook of Prescription Drugs and Comparative Risk Assessment. Gulf Professional Publishing. ISBN 978-0-444-50763-1.
- ^ a b c http://www.mesotheliomaweb.org/mesothelioma/treatment/chemotherapy/anti-Enausea-treatment/
- ^ Pae C-U. Low-dose mirtazapine may be successful treatment option for severe nausea and vomiting. Progress in Neuro-Psychopharmacology and Biological Psychiatry [Internet]. 2006 Aug 30 [cited 2013 Sep 27];30(6):1143–5. Available from: http://www.sciencedirect.com/science/article/pii/S0278584606000935
- ^ Kast R e., Foley K f. Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. European Journal of Cancer Care [Internet]. 2007 [cited 2013 Sep 27];16(4):351–4. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2354.2006.00760.x/abstract
- ^ National Institute of Mental Health. PDSD Ki Database (Internet) [cited 2013 Sep 27]. Chapel Hill (NC): University of North Carolina. 1998-2013. Available from: http://pdsp.med.unc.edu/pdsp.php
- ^ Abdel-Aziz H, Windeck T, Ploch M, Verspohl EJ. (2006-01-13), "Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum.", Eur J Pharmacol. 530 (1-2): 136–43, doi:10.1016/j.ejphar.2005.10.049, PMID 16364290
- ^ Huang, Q.; Iwamoto, Y.; Aoki, S.; Tanaka, N.; Tajima, K.; Yamahara, J.; Takaishi, Y.; Yoshida, M.; Tomimatsu, T.; Tamai, Y. (1991). "Anti-5-hydroxytryptamine3 effect of galanolactone, diterpenoid isolated from ginger". Chemical & pharmaceutical bulletin 39 (2): 397–399. doi:10.1248/cpb.39.397. PMID 2054863.
- ^ Marx, WM; Teleni L; McCarthy AL; Vitetta L; McKavanagh D; Thomson D; Isenring E. (2013). "Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review". Nutr Rev 71 (4): 245–54. doi:10.1111/nure.12016. PMID 23550785.
- ^ Ernst, E.; Pittler, M.H. (1 March 2000). "Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials" (PDF). British Journal of Anesthesia 84 (3): 367–371. doi:10.1093/oxfordjournals.bja.a013442. PMID 10793599. Retrieved 6 September 2006.
- ^ hoe 2#section1 Muscimol. Chemical Data Sheet, Database of Hazardous Materials, CAMEO chemicals
See also
- Emetic — substances that induce nausea and vomiting
- Hyperemesis gravidarum
- Chemotherapy
- Cancer and nausea
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Antiemetics (A04)
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5-HT3 Serotonin ion
channel antagonists |
- Alosetron
- Azasetron
- Bemesetron
- Cilansetron
- Clozapine
- Dazopride
- Dolasetron
- Granisetron
- Lerisetron
- Metoclopramide
- Mianserin
- Mirtazapine
- Olanzapine
- Ondansetron
- Palonosetron
- Quetiapine
- Ramosetron
- Ricasetron
- Tropisetron
- Zatosetron
|
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5-HT Serotonin G-protein
receptor antagonists |
- Clozapine
- Cyproheptadine
- Hydroxyzine
- Olanzapine
- Risperidone
- Ziprasidone
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CB1 Agonists
(Cannabinoids) |
- Dronabinol
- Nabilone
- Nonabine
- Tetrahydrocannabinol
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| D2/D3 Antagonists |
- Alizapride
- Bromopride
- Chlorpromazine
- Clebopride
- Domperidone
- Haloperidol
- Hydroxyzine
- Itopride
- Metoclopramide
- Metopimazine
- Prochlorperazine
- Thiethylperazine
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H1 antagonists
(Antihistamines) |
- Cyclizine
- Dimenhydrinate
- Diphenhydramine
- Hydroxyzine
- Meclozine
- Promethazine
|
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mACh antagonists
(Anticholinergics) |
- Atropine
- Diphenhydramine
- Hydroxyzine (very mild)
- Hyoscyamine
- Scopolamine
|
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| NK1 Antagonists |
- Aprepitant
- Casopitant
- Ezlopitant
- Fosaprepitant
- Maropitant
- Netupitant
- Rolapitant
- Vestipitant
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| Others |
- Cerium oxalate
- Dexamethasone
- Lorazepam
- Midazolam
- Propofol
- Trimethobenzamide
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Index of digestion
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| Description |
- Anatomy
- Physiology
- Development
|
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| Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
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| Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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UpToDate Contents
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★リンクテーブル★
[★]
- 英
- antiemetic drug, antiemetic,antiemetic drugs, antinauseant
- 同
- 制吐薬 "鎮吐"の方が一般的らしい
- 関
- 薬理学、鎮吐薬一覧、セロトニン受容体、嘔吐
抗セロトニン薬
GOO. 1000-
嘔吐が起こるのは
①嘔吐中枢
延髄、網様体背外側部
②chemoreceptor trigger zone(CTz)
第4脳室
ジキタリスが刺激
中枢性嘔吐：嘔吐中枢とCTzを刺激
反射性嘔吐：消化管→求心路→嘔吐中枢
抗ガン剤投与時に起きる吐き気の機序
①血中に入った抗ガン剤が直接CTzを刺激
②抗癌剤により腸管細胞(enterochromaffin cell)から化学神経伝達物質が生産され、CTzを経てあるいは直接嘔吐中枢に作用する。
中枢神経終末にある5-HT3受容体を介して嘔吐が起こる
[★]
- 英
- antiemesis、antiemetic
- 関
- 制吐剤、制吐薬、鎮吐薬、鎮吐、制吐作用
[★]
- 英
- antiemetic、antiemetic drug
- 関
- 制吐、制吐薬、鎮吐薬
[★]
- 関
- antiemetic
[★]
- 関
- antiemetic、antiemetic drug、antiemetics
[★]
5-HT3受容体拮抗型制吐薬