WordNet

a substance from which another substance is formed (especially by a metabolic reaction)
a person who goes before or announces the coming of another (同)forerunner
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
(pathology) a waxy translucent complex protein resembling starch that results from degeneration of tissue
a non-nitrogenous food substance consisting chiefly of starch; any substance resembling starch
informal term for information; "give me the gen on your new line of computers"

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases
2. アルツハイマー病の遺伝学 genetics of alzheimer disease
3. アルツハイマー病の疫学、病理、および病因 epidemiology pathology and pathogenesis of alzheimer disease
4. 成人における早期発症の認知症 early onset dementia in adults
5. 認知機能低下および認知症の危険因子 risk factors for cognitive decline and dementia

Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease.

Wilcock DM1, Hurban J2, Helman AM3, Sudduth TL4, McCarty KL4, Beckett TL3, Ferrell JC4, Murphy MP3, Abner EL5, Schmitt FA6, Head E7.
Neurobiology of aging.Neurobiol Aging.2015 Sep;36(9):2468-74. doi: 10.1016/j.neurobiolaging.2015.05.016. Epub 2015 May 30.
Down syndrome (DS) is the most common genetic cause of intellectual disability and is primarily caused by the triplication of chromosome 21. The overexpression of amyloid precursor protein gene may be sufficient to drive Alzheimer's disease (AD) neuropathology that is observed in virtually all indiv
PMID 26103884

Hayakawa M1, Itoh M1, Ohta K1, Li S1, Ueda M1, Wang MX1, Nishida E1, Islam S1, Suzuki C1, Ohzawa K1, Kobori M2, Inuzuka T3, Nakagawa T4.
Neurobiology of aging.Neurobiol Aging.2015 Sep;36(9):2509-18. doi: 10.1016/j.neurobiolaging.2015.05.006. Epub 2015 May 15.
The production of amyloid β (Aβ) in the brain from Aβ precursor protein (APP) through γ-secretase is important for the pathogenesis of Alzheimer's disease (AD). Our previous studies have demonstrated that autophagy impairment and endoplasmic reticulum stress increase presenilin 1 expression and
PMID 26070242

Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and the Recessive A2V Familial Alzheimer's Disease Mutation.

Zheng X, Liu D, Roychaudhuri R, Teplow DB, Bowers MT.
ACS chemical neuroscience.ACS Chem Neurosci.2015 Aug 5. [Epub ahead of print]
Oligomeric states of the amyloid β-protein (Aβ) appear to be causally related to Alzheimer's disease (AD). Recently, two familial mutations in the amyloid precursor protein gene have been described, both resulting in amino acid substitutions at Ala2 (A2) within Aβ. An A2V mutation causes autosoma
PMID 26244608

A Second Pedigree with Amyloid-less Familial Alzheimer's Disease Harboring an Identical Mutation in the Amyloid Precursor Protein Gene (E693delta)

Kutoku Yumiko,Ohsawa Yutaka,Kuwano Ryozo,Ikeuchi Takeshi,Inoue Haruhisa,Ataka Suzuka,Shimada Hiroyuki,Mori Hiroshi,Sunada Yoshihide
Internal Medicine 54(2), 205-208, 2015
… positron emission tomography (PET) imaging revealed a large reduction in the level of glucose uptake without amyloid deposition in the cerebral cortex. … We identified a homozygous microdeletion within the amyloid β (Aβ) coding sequence in the amyloid precursor protein (APP) gene (c.2080_2082delGAA, p.E693del) in three affected siblings and a heterozygous microdeletion in an unaffected sibling. …
NAID 130004903009

AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform

Mori Masayuki,Tiang Geng,Higuchi Keiichi
AMYLOID
… The CE/J mouse strain is resistant to amyloid A protein (AA) amyloidosis. … In contrast to AA amyloidosis-susceptible mouse strains that concomitantly express serum amyloid A precursor protein (SAA) types 1 and 2 isoforms encoded by the Saa1 and Saa2 genes, respectively, in response to inflammatory stimulation from the liver, CE/J mice express only a single SAA isoform named SAA2.2. …
NAID 120005468426