alcoholic liver cirrhosis

アルコール性肝硬変

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alcoholic cirrhosis

WordNet

1. pursue a positive and satisfying existence; "You must accept yourself and others if you really want to live"
2. actually being performed at the time of hearing or viewing; "a live television program"; "brought to you live from Lincoln Center"; "live entertainment involves performers actually in the physical presence of a live audience" (同)unrecorded
3. abounding with life and energy; "the club members are a really live bunch"
4. charged with an explosive; "live ammunition"; "a live bomb"
5. exerting force or containing energy; "live coals"; "tossed a live cigarette out the window"; "got a shock from a live wire"; "live ore is unmined ore"; "a live bomb"; "a live ball is one in play"
6. highly reverberant; "a live concert hall"
7. in current use or ready for use; "live copy is ready to be set in type or already set but not yet proofread"
8. lead a certain kind of life; live in a certain style; "we had to live frugally after the war"
9. not recorded; "the opera was broadcast live"
10. of current relevance; "a live issue"; "still a live option"
11. characteristic of or containing alcohol; "alcoholic drinks"
12. a person who drinks alcohol to excess habitually (同)alky, dipsomaniac, boozer, lush, soaker, souse
13. addicted to alcohol; "alcoholic expatriates in Paris"- Carl Van Doren (同)alcohol-dependent
14. a person who has a special life style; "a high liver"
15. large and complicated reddish-brown glandular organ located in the upper right portion of the abdominal cavity; secretes bile and functions in metabolism of protein and carbohydrate and fat; synthesizes substances involved in the clotting of the blood; sy
16. liver of an animal used as meat
17. someone who lives in a place; "a liver in cities"
18. any of a series of volatile hydroxyl compounds that are made from hydrocarbons by distillation
19. a liquor or brew containing alcohol as the active agent; "alcohol (or drink) ruined him" (同)alcoholic drink, alcoholic_beverage, intoxicant, inebriant
20. a chronic disease interfering with the normal functioning of the liver; the major cause is chronic alcoholism (同)cirrhosis of the liver

PrepTutorEJDIC

1. 『生きている』,生命がある / 《副詞[句]を伴って》〈人などが〉『生き続ける』 / 〈物事が〉長く続く,存続する / 《場所を表す副詞[句]を伴って》〈人などが〉『住む』,居住する / 《副詞[句]を伴って》『生活する』,暮らす / 生人を楽しむ,おもしろく桟らす / 《a+形容詞癌lifeを目的語にして》〈…を生活〉‘を'する / 〈思想など〉‘を'実銭する
2. 《名詞の前にのみ用いて》『生きている』 / 『活気のある』 / (問題などが)当面の / 燃えている / (弾丸などが)まだ爆発してない,未発の / まだ動いている(働いている),有効な / 電流が通じている / (放走が)生の,実況の
3. アルコールの,アルコール性の / アルコールのはいった;アルコール漬けの / アルコール中毒の / アルコール中毒[患]者
4. (ある態度で)生活する人;居住者
5. 〈C〉『肝臓』 / 〈U〉(食用にする)動物の肝臓,レバー
6. 『アルコール』,酒精 / 『アルコール飲料』,酒
7. 肝硬変

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/13 15:58:23」(JST)

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Cirrhosis
The abdomen of a person with cirrhosis showing massive fluid buildup and very visible veins
Classification and external resources
Pronunciation	/sɪˈroʊsɪs/
Specialty	Gastroenterology
ICD-10	K70.3, K71.7, K74
ICD-9-CM	571
DiseasesDB	2729
MedlinePlus	000255
eMedicine	med/3183 radio/175
Patient UK	Cirrhosis
MeSH	D008103

Cirrhosis is a condition in which the liver does not function properly due to long-term damage. Typically, the disease comes on slowly over months or years. Early on, there are often no symptoms. As the disease worsens, a person may become tired, weak, itchy, have swelling in the lower legs, develop yellow skin, bruise easily, have fluid build up in the abdomen, or develop spider-like blood vessels on the skin. The fluid build-up in the abdomen may become spontaneously infected. Other complications include hepatic encephalopathy, bleeding from dilated veins in the esophagus or dilated stomach veins, and liver cancer. Hepatic encephalopathy results in confusion and possibly unconsciousness.

Cirrhosis is most commonly caused by alcohol, hepatitis B, hepatitis C, and non-alcoholic fatty liver disease. Typically, more than two or three drinks per day over a number of years is required for alcoholic cirrhosis to occur. Non-alcoholic fatty liver disease is due to a number of reasons, including being overweight, diabetes, high blood fats, and high blood pressure. A number of less common causes include autoimmune hepatitis, primary biliary cirrhosis, hemochromatosis, certain medications, and gallstones. Cirrhosis is characterized by the replacement of normal liver tissue by scar tissue. These changes lead to loss of liver function. Diagnosis is based on blood testing, medical imaging, and liver biopsy.

Some causes of cirrhosis, such as hepatitis B, can be prevented by vaccination. Treatment partly depends on the underlying cause. The goal is often to prevent worsening and complications. Avoiding alcohol is recommended. Hepatitis B and C may be treatable with antiviral medications. Autoimmune hepatitis may be treated with steroid medications. Ursodiol may be useful if the disease is due to blockage of the bile ducts. Other medications may be useful for complications such as swelling, hepatic encephalopathy, and dilated esophageal veins. In severe cirrhosis, a liver transplant may be an option.

Cirrhosis resulted in 1.2 million deaths in 2013, up from 0.8 million deaths in 1990. Of these, alcohol caused 384,000, hepatitis C caused 358,000, and hepatitis B caused 317,000. In the United States, more men die of cirrhosis than women. The first known description of the condition is by Hippocrates in the 5th century BCE. The word cirrhosis is from Greek: κίρρωσις; neologism from kirrhos κιρρός "yellowish" and the suffix -osis (-ωσις) meaning "condition".

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An explanation of cirrhosis

Signs and symptoms

Liver cirrhosis.

Cirrhosis has many possible manifestations. These signs and symptoms may be either as a direct result of the failure of liver cells or secondary to the resultant portal hypertension. There are also some manifestations whose causes are nonspecific, but may occur in cirrhosis. Likewise, the absence of any does not rule out the possibility of cirrhosis. Cirrhosis of the liver is slow and gradual in its development. It is usually well advanced before its symptoms are noticeable enough to cause alarm. Weakness and loss of weight may be early symptoms.

Liver dysfunction

The following features are as a direct consequence of liver cells not functioning.

• Spider angiomata or spider nevi are vascular lesions consisting of a central arteriole surrounded by many smaller vessels (hence the name "spider") and occur due to an increase in estradiol. One study found that spider angiomata occur in about 1/3 of cases.
• Palmar erythema is a reddening of palms at the thenar and hypothenar eminences also as a result of increased estrogen.
• Gynecomastia, or increase in breast gland size in men that is not cancerous, is caused by increased estradiol and can occur in up to 2/3 of patients. This is different from increase in breast fat in overweight people.
• Hypogonadism, a decrease in sex hormones manifest as impotence, infertility, loss of sexual drive, and testicular atrophy, can result from primary gonadal injury or suppression of hypothalamic/pituitary function. Hypogonadism is associated with cirrhosis due to alcoholism and hemochromatosis.
• Liver size can be enlarged, normal, or shrunken in people with cirrhosis.
• Ascites, accumulation of fluid in the peritoneal cavity (space in the abdomen), gives rise to flank dullness (needs about 1500 ml to detect flank dullness). This may be visible as increase in abdominal girth.
• Fetor hepaticus is a musty breath odor resulting from increased dimethyl sulfide.
• Jaundice is yellow discoloration of the skin and mucous membranes (with the eye being especially noticeable) due to increased bilirubin (at least 2–3 mg/dL or 30 µmol/L). Urine may also appear dark.

Portal hypertension

Liver cirrhosis increases resistance to blood flow and higher pressure in the portal venous system, resulting in portal hypertension. Effects of portal hypertension include:

• Splenomegaly (increase in size of the spleen) is found in 35% to 50% of patients.
• Esophageal varices result from collateral portal blood flow through vessels in the stomach and esophagus (a process called portacaval anastomosis). When these blood vessels become enlarged, they are called varices and are more likely to rupture. Variceal rupture often leads to severe bleeding, which can be fatal.
• Caput medusa are dilated periumbilical collateral veins due to portal hypertension. Blood from the portal venous system may be shunted through the periumbilical veins and ultimately to the abdominal wall veins, manifesting as a pattern that may resemble the head of Medusa.
• Cruveilhier-Baumgarten murmur is a venous hum heard in the epigastric region (on examination by stethoscope) due to collateral connections forming between portal system and the periumbilical veins as a result of portal hypertension.

Unestablished cause

There are some changes seen in cirrhosis whose causes are not clearly known. They may also be a sign of other non-liver related causes.

• Nail changes.
  • Muehrcke's lines - paired horizontal bands separated by normal color resulting from hypoalbuminemia (inadequate production of albumin). It is not specific for cirrhosis.
  • Terry's nails (double nails) - proximal two-thirds of the nail plate appears white with distal one-third red, also due to hypoalbuminemia
  • Clubbing - angle between the nail plate and proximal nail fold > 180 degrees. It is not specific for cirrhosis and can therefore happen in a number of conditions
• Hypertrophic osteoarthropathy. Chronic proliferative periostitis of the long bones that can cause considerable pain. It is not specific for cirrhosis.
• Dupuytren's contracture. Thickening and shortening of palmar fascia (tissue on the palm of the hands) that leads to flexion deformities of the fingers. Caused by fibroblastic proliferation (increased growth) and disorderly collagen deposition. It is relatively common (33% of patients).
• Other. Weakness, fatigue, anorexia, weight loss.

Advanced disease

As the disease progresses, complications may develop. In some people, these may be the first signs of the disease.

• Bruising and bleeding resulting from decreased production of coagulation factors.
• Hepatic encephalopathy - the liver does not clear ammonia and related nitrogenous substances from the blood, which are carried to the brain, affecting cerebral functioning: neglect of personal appearance, unresponsiveness, forgetfulness, trouble concentrating, or changes in sleep habits. This can be seen on exam by asterixis which is bilateral asynchronous flapping of outstretched, dorsiflexed hands seen in patients with hepatic encephalopathy.
• Sensitivity to medication caused by decreased metabolism of the active compounds.
• Acute kidney injury (particularly hepatorenal syndrome)

Causes

It has many possible causes; sometimes more than one cause is present in the same person. Globally, 57% of cirrhosis is attributable to either hepatitis B (30%) or hepatitis C (27%). Alcohol consumption is another important cause, accounting for about 20% of the cases.

• Alcoholic liver disease (ALD). Alcoholic cirrhosis develops for 10–20% of individuals who drink heavily for a decade or more. Alcohol seems to injure the liver by blocking the normal metabolism of protein, fats, and carbohydrates. This injury happens through the formation of acetaldehyde from alcohol which itself is reactive, but also leads to the accumulation of products in the liver. Patients may also have concurrent alcoholic hepatitis with fever, hepatomegaly, jaundice, and anorexia. AST and ALT are both elevated but less than 300 IU/litre with an AST:ALT ratio > 2.0, a value rarely seen in other liver diseases. In the United States, 2/5 of cirrhosis-related deaths are due to alcohol.
• Non-alcoholic steatohepatitis (NASH). In NASH, fat builds up in the liver and eventually causes scar tissue. This type of hepatitis appears to be associated with obesity (40% of NASH patients) diabetes, protein malnutrition, coronary artery disease, and treatment with corticosteroid medications. This disorder is similar to that of alcoholic liver disease but the patient does not have an alcohol history. A biopsy is needed for diagnosis.
• Chronic hepatitis C. Infection with the hepatitis C virus causes inflammation of the liver and a variable grade of damage to the organ. Over several decades this inflammation and grade change can lead to cirrhosis. Among patients with chronic hepatitis C 20-30% will develop cirrhosis. Host risk factors include human promoter polymorphisms such as TGF-β1 and angiotensin as well as host immune phenotype variations, such as immunosuppressed patients . Cirrhosis caused by hepatitis C and alcoholic liver disease are the most common reasons for liver transplant. Can be diagnosed with serologic assays that detect hepatitis C antibody or viral RNA. The enzyme immunoassay, EIA-2, is the most commonly used screening test in the US.
• Chronic hepatitis B. The hepatitis B virus causes liver inflammation and injury that over several decades can lead to cirrhosis. Hepatitis D is dependent on the presence of hepatitis B and accelerates cirrhosis in co-infection. Chronic hepatitis B can be diagnosed with detection of HBsAG > 6 months after initial infection. HBeAG and HBV DNA are determined to assess whether patient needs antiviral therapy.
• Primary biliary cirrhosis. Damage of the bile ducts leading to secondary liver damage. May be asymptomatic or complain of fatigue, pruritus, and non-jaundice skin hyperpigmentation with hepatomegaly. There is prominent alkaline phosphatase elevation as well as elevations in cholesterol and bilirubin. Gold standard diagnosis is antimitochondrial antibodies (positive in 90% of PBC patients). Liver biopsy if done shows bile duct lesions. It is more common in women.
• Primary sclerosing cholangitis. PSC is a progressive cholestatic disorder presenting with pruritus, steatorrhea, fat-soluble vitamin deficiencies, and metabolic bone disease. There is a strong association with inflammatory bowel disease (IBD), especially ulcerative colitis. Diagnosis is best with contrast cholangiography showing diffuse, multifocal strictures and focal dilation of bile ducts, leading to a beaded appearance. Non-specific serum immunoglobulins may also be elevated.
• Autoimmune hepatitis. This disease is caused by the immunologic damage to the liver causing inflammation and eventually scarring and cirrhosis. Findings include elevations in serum globulins, especially gamma globulins. Therapy with prednisone and/or azathioprine is beneficial. Cirrhosis due to autoimmune hepatitis still has 10-year survival of 80+ %.
• Hereditary hemochromatosis. Usually presents with a family history of cirrhosis, skin hyperpigmentation, diabetes mellitus, pseudogout, and/or cardiomyopathy, all due to signs of iron overload. Labs show fasting transferrin saturation of > 60% and ferritin > 300 ng/ml. Genetic testing may be used to identify HFE mutations. If these mutations are present, a biopsy may not need to be performed. Treatment is with phlebotomy to lower total body iron levels.
• Wilson's disease. Autosomal recessive disorder characterized by low serum ceruloplasmin and increased hepatic copper content on liver biopsy, and elevated 24-hour urine copper. May also have Kayser-Fleischer rings in the cornea and altered mental status. This condition affects 1 in 30,000 people.
• Indian childhood cirrhosis is a form of neonatal cholestasis characterised by deposition of copper in the liver.
• Alpha 1-antitrypsin deficiency (A1AD). Autosomal recessive disorder of decreased levels of the enzyme alpha 1--antitrypsin. Patients may also have COPD, especially if they have a history of tobacco smoking. Serum AAT levels are low and liver biopsy is positive for Periodic acid-Schiff Recombinant AAT is used to prevent lung disease due to AAT deficiency.
• Cardiac cirrhosis. Due to chronic right sided heart failure which leads to liver congestion.
• Galactosemia
• Glycogen storage disease type IV
• Cystic fibrosis
• Hepatotoxic drugs or toxins

Pathophysiology

The liver plays a vital role in synthesis of proteins (for example, albumin, clotting factors and complement), detoxification, and storage (for example, vitamin A). In addition, it participates in the metabolism of lipids and carbohydrates.

Cirrhosis is often preceded by hepatitis and fatty liver (steatosis), independent of the cause. If the cause is removed at this stage, the changes are still fully reversible.

The pathological hallmark of cirrhosis is the development of scar tissue that replaces normal parenchyma. This scar tissue blocks the portal flow of blood through the organ therefore disturbing normal function. Recent research shows the pivotal role of the stellate cell, a cell type that normally stores vitamin A, in the development of cirrhosis. Damage to the hepatic parenchyma (due to inflammation) leads to activation of the stellate cell, which increases fibrosis (through production of myofibroblasts) and obstructs blood flow in the circulation. In addition, it secretes TGF-β₁, which leads to a fibrotic response and proliferation of connective tissue. Furthermore, it secretes TIMP 1 and 2, naturally occurring inhibitors of matrix metalloproteinases, which prevents them from breaking down fibrotic material in the extracellular matrix.

The fibrous tissue bands (septa) separate hepatocyte nodules, which eventually replace the entire liver architecture, leading to decreased blood flow throughout. The spleen becomes congested, which leads to hypersplenism and increased sequestration of platelets. Portal hypertension is responsible for most severe complications of cirrhosis.

Diagnosis

Micrograph showing cirrhosis. Trichrome stain.

The gold standard for diagnosis of cirrhosis is a liver biopsy, through a percutaneous, transjugular, laparoscopic, or fine-needle approach. A biopsy is not necessary if the clinical, laboratory, and radiologic data suggests cirrhosis. Furthermore, there is a small but significant risk to liver biopsy, and cirrhosis itself predisposes for complications caused by liver biopsy. The best predictors of cirrhosis are ascites, platelet count <160,000/mm3, spider angiomata and Bonacini cirrhosis discriminant score greater than 7.

Lab findings

The following findings are typical in cirrhosis:

• Thrombocytopenia - typically multifactorial. Due to alcoholic marrow suppression, sepsis, lack of folate, sequestering in the spleen as well as decreased thrombopoietin. However, this rarely results in platelet count < 50 000/mL.
• Aminotransferases - AST and ALT are moderately elevated, with AST > ALT. However, normal aminotransferases do not preclude cirrhosis.
• Alkaline phosphatase - slightly elevated but less than 2-3 times the upper limit of normal.
• Gamma-glutamyl transferase – correlates with AP levels. Typically much higher in chronic liver disease from alcohol.
• Bilirubin - Levels normal when compensated but may elevate as cirrhosis progresses.
• Albumin - levels fall as the synthetic function of the liver declines with worsening cirrhosis since albumin is exclusively synthesized in the liver
• Prothrombin time - increases since the liver synthesizes clotting factors.
• Globulins - increased due to shunting of bacterial antigens away from the liver to lymphoid tissue.
• Serum sodium - hyponatremia due to inability to excrete free water resulting from high levels of ADH and aldosterone.
• Leukopenia and neutropenia - due to splenomegaly with splenic margination.
• Coagulation defects - the liver produces most of the coagulation factors and thus coagulopathy correlates with worsening liver disease.

There is now a validated and patented combination of 6 of these markers as non-invasive biomarker of fibrosis (and so of cirrhosis): FibroTest.

Other laboratory studies performed in newly diagnosed cirrhosis may include:

• Serology for hepatitis viruses, autoantibodies (ANA, anti-smooth muscle, anti-mitochondria, anti-LKM)
• Ferritin and transferrin saturation: markers of iron overload as in hemochromatosis, copper and ceruloplasmin: markers of copper overload as in Wilson's disease
• Immunoglobulin levels (IgG, IgM, IgA) - these immunoglobins are non-specific but may help in distinguishing various causes
• Cholesterol and glucose
• Alpha 1-antitrypsin

Imaging

Liver cirrhosis with ascites

Liver cirrhosis as seen on a CT of the abdomen in transverse orientation.

Ultrasound is routinely used in the evaluation of cirrhosis. It may show a small and nodular liver in advanced cirrhosis along with increased echogenicity with irregular appearing areas. Other findings suggestive of cirrhosis in imaging are an enlarged caudate lobe, widening of the liver fissures and enlargement of the spleen. An enlarged spleen (splenomegaly), which normally measures less than 11–12 cm in adults, is suggestive of cirrhosis with portal hypertension in the right clinical setting. Ultrasound may also screen for hepatocellular carcinoma, portal hypertension, and Budd-Chiari syndrome (by assessing flow in the hepatic vein).

Cirrhosis is diagnosed with a variety of elastography techniques. Because a cirrhotic liver is generally stiffer than a healthy one, imaging the liver's stiffness can give diagnostic information about the location and severity of cirrhosis. Techniques used include transient elastography, acoustic radiation force impulse imaging, supersonic shear imaging and magnetic resonance elastography. Compared to a biopsy, elastography can sample a much larger area and is painless. It shows reasonable correlation with the severity of cirrhosis.

Other tests performed in particular circumstances include abdominal CT and liver/bile duct MRI (MRCP).

Endoscopy

Gastroscopy (endoscopic examination of the esophagus, stomach, and duodenum) is performed in patients with established cirrhosis to exclude the possibility of esophageal varices. If these are found, prophylactic local therapy may be applied (sclerotherapy or banding) and beta blocker treatment may be commenced.

Rarely are diseases of the bile ducts, such as primary sclerosing cholangitis, causes of cirrhosis. Imaging of the bile ducts, such as ERCP or MRCP (MRI of biliary tract and pancreas) may aid in the diagnosis.

Pathology

Cirrhosis leading to hepatocellular carcinoma (autopsy specimen).

Macroscopically, the liver is initially enlarged, but with progression of the disease, it becomes smaller. Its surface is irregular, the consistency is firm, and the color is often yellow (if associated steatosis). Depending on the size of the nodules there are three macroscopic types: micronodular, macronodular, and mixed cirrhosis. In micronodular form (Laennec's cirrhosis or portal cirrhosis) regenerating nodules are under 3 mm. In macronodular cirrhosis (post-necrotic cirrhosis), the nodules are larger than 3 mm. The mixed cirrhosis consists of nodules with different sizes.

However, cirrhosis is defined by its pathological features on microscopy: (1) the presence of regenerating nodules of hepatocytes and (2) the presence of fibrosis, or the deposition of connective tissue between these nodules. The pattern of fibrosis seen can depend on the underlying insult that led to cirrhosis. Fibrosis can also proliferate even if the underlying process that caused it has resolved or ceased. The fibrosis in cirrhosis can lead to destruction of other normal tissues in the liver: including the sinusoids, the space of Disse, and other vascular structures, which leads to altered resistance to blood flow in the liver and portal hypertension.

As cirrhosis can be caused by many different entities which injure the liver in different ways, cause specific abnormalities may be seen. For example, in chronic hepatitis B, there is infiltration of the liver parenchyma with lymphocytes. In cardiac cirrhosis there are erythrocytes and a greater amount of fibrosis in the tissue surrounding the hepatic veins. In primary biliary cirrhosis, there is fibrosis around the bile duct, the presence of granulomas and pooling of bile. Lastly in alcoholic cirrhosis, there is infiltration of the liver with neutrophils.

Grading

The severity of cirrhosis is commonly classified with the Child-Pugh score. This score uses bilirubin, albumin, INR, presence and severity of ascites, and encephalopathy to classify patients in class A, B, or C. Class A has a favourable prognosis, while class C is at high risk of death. It was devised in 1964 by Child and Turcotte and modified in 1973 by Pugh and others.

More modern scores, used in the allocation of liver transplants but also in other contexts, are the Model for End-Stage Liver Disease (MELD) score and its pediatric counterpart, the Pediatric End-Stage Liver Disease (PELD) score.

The hepatic venous pressure gradient, (difference in venous pressure between afferent and efferent blood to the liver) also determines severity of cirrhosis, although hard to measure. A value of 16 mm or more means a greatly increased risk of dying.

Prevention

Key prevention strategies for cirrhosis and its compensation are population-wide interventions to reduce alcohol intake (through pricing strategies, public health campaigns, and personal counseling), programs to reduce the transmission of viral hepatitis, and screening of relatives of people with hereditary liver diseases.

Little is known on modulators of cirrhosis risk and progression. Coffee consumption appears to help protect against cirrhosis.

Management

Generally, liver damage from cirrhosis cannot be reversed, but treatment could stop or delay further progression and reduce complications. A healthy diet is encouraged, as cirrhosis may be an energy-consuming process. Close follow-up is often necessary. Antibiotics are prescribed for infections, and various medications can help with itching. Laxatives, such as lactulose, decrease risk of constipation; their role in preventing encephalopathy is limited.

Alcoholic cirrhosis caused by alcohol abuse is treated by abstaining from alcohol. Treatment for hepatitis-related cirrhosis involves medications used to treat the different types of hepatitis, such as interferon for viral hepatitis and corticosteroids for autoimmune hepatitis. Cirrhosis caused by Wilson's disease, in which copper builds up in organs, is treated with chelation therapy (for example, penicillamine) to remove the copper.

Preventing further liver damage

Regardless of the underlying cause of cirrhosis, alcohol and paracetamol, as well as other potentially damaging substances, are discouraged. Vaccination of susceptible patients should be considered for Hepatitis A and Hepatitis B.

Transplantation

Main article: Liver transplantation

If complications cannot be controlled or when the liver ceases functioning, liver transplantation is necessary. Survival from liver transplantation has been improving over the 1990s, and the five-year survival rate is now around 80%. The survival rate depends largely on the severity of disease and other medical problems in the recipient. In the United States, the MELD score is used to prioritize patients for transplantation. Transplantation necessitates the use of immune suppressants (ciclosporin or tacrolimus).

Decompensated cirrhosis

In patients with previously stable cirrhosis, decompensation may occur due to various causes, such as constipation, infection (of any source), increased alcohol intake, medication, bleeding from esophageal varices or dehydration. It may take the form of any of the complications of cirrhosis listed below.

Patients with decompensated cirrhosis generally require admission to hospital, with close monitoring of the fluid balance, mental status, and emphasis on adequate nutrition and medical treatment - often with diuretics, antibiotics, laxatives and/or enemas, thiamine and occasionally steroids, acetylcysteine and pentoxifylline. Administration of saline is avoided as it would add to the already high total body sodium content that typically occurs in cirrhosis.

Palliative care

Palliative care is specialized medical care that focuses on providing patients with relief from the symptoms, pain, and stress of a serious illness, such as cirrhosis. The goal of palliative care is to improve quality of life for both the patient and the patient's family and it is appropriate at any stage and for any type of cirrhosis.

Especially in the later stages, people with cirrhosis experience significant symptoms such as abdominal swelling, itching, leg edema, and chronic abdominal pain which would be amenable for treatment through palliative care. Because the disease is not curable without a transplant, palliative care can also help with discussions regarding the person's wishes concerning health care power of attorney, Do Not Resuscitate decisions and life support, and potentially hospice. Despite proven benefit, people with cirrhosis are rarely referred to palliative care.

Complications

Ascites

Salt restriction is often necessary, as cirrhosis leads to accumulation of salt (sodium retention). Diuretics may be necessary to suppress ascites. Diuretic options for inpatient treatment include aldosterone antagonists (spironolactone) and loop diuretics. Aldosterone antagonists are preferred for people who can take oral medications and are not in need of an urgent volume reduction. Loop diuretics can be added as additional therapy.

If a rapid reduction of volume is required, paracentesis is the preferred option. This procedure requires the insertion of a plastic tube into the peritoneal cavity. Human albumin solution is usually given to prevent complications from the rapid reduction. In addition to being more rapid than diuretics, 4–5 liters of paracentesis is more successful in comparison to diuretic therapy.

Esophageal variceal bleeding

For portal hypertension, propranolol is a commonly used agent to lower blood pressure over the portal system. In severe complications from portal hypertension, transjugular intrahepatic portosystemic shunting (TIPS) is occasionally indicated to relieve pressure on the portal vein. As this shunting can worsen encephalopathy, it is reserved for those patients at low risk of encephalopathy. TIPS is generally regarded only as a bridge to liver transplantation or as a palliative measure.

Hepatic encephalopathy

High-protein food increases the nitrogen balance, and would theoretically increase encephalopathy; in the past, this was therefore eliminated as much as possible from the diet. Recent studies show that this assumption was incorrect, and high-protein foods are even encouraged to maintain adequate nutrition.

Hepatorenal syndrome

The hepatorenal syndrome is defined as a urine sodium less than 10 mmol/L and a serum creatinine > 1.5 mg/dl (or 24 hour creatinine clearance less than 40 ml/min) after a trial of volume expansion without diuretics.

Spontaneous bacterial peritonitis

People with ascites due to cirrhosis are at risk of spontaneous bacterial peritonitis.

Portal hypertensive gastropathy

Which refers to changes in the mucosa of the stomach in people with portal hypertension, and is associated with cirrhosis severity.

Infection

Cirrhosis can cause immune system dysfunction, leading to infection. Signs and symptoms of infection may be nonspecific and are more difficult to recognize (for example, worsening encephalopathy but no fever).

Hepatocellular carcinoma

Hepatocellular carcinoma is a primary liver cancer that is more common in people with cirrhosis. People with known cirrhosis are often screened intermittently for early signs of this tumor, and screening has been shown to improve outcomes.

Epidemiology

Disability-adjusted life year for cirrhosis of the liver per 100,000 inhabitants in 2004.

  no data

  <50

  50-100

  100-200

  200-300

  300-400

  400-500

  500-600

  600-700

  700-800

  800-900

  900-1000

  >1000

Cirrhosis and chronic liver disease were the tenth leading cause of death for men and the twelfth for women in the United States in 2001, killing about 27,000 people each year. Also, the cost of cirrhosis in terms of human suffering, hospital costs, and lost productivity is high. Cirrhosis is more common in men than in women.

Established cirrhosis has a 10-year mortality of 34–66%, largely dependent on the cause of the cirrhosis; alcoholic cirrhosis has a worse prognosis than primary biliary cirrhosis and cirrhosis due to hepatitis. The risk of death due to all causes is increased twelvefold; if one excludes the direct consequences of the liver disease, there is still a fivefold increased risk of death in all disease categories.

Etymology

The word "cirrhosis" is a neologism derived from Greek kirrhós meaning "yellowish, tawny" (the orange-yellow colour of the diseased liver) and the suffix -osis, i.e. "condition" in medical terminology. While the clinical entity was known before, it was René Laennec who gave it this name (in the same 1819 work in which he also described the stethoscope).

References

External links

• Cirrhosis of the Liver at the National Digestive Diseases Information Clearinghouse (NDDIC). NIH Publication No. 04-1134, December 2003.

UpToDate Contents

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• 1. アルコール性肝疾患およびアルコール性肝炎の予後および治療 prognosis and treatment of alcoholic liver disease and alcoholic hepatitis
• 2. アルコール性肝疾患の臨床症状および診断 clinical manifestations and diagnosis of alcoholic liver disease
• 3. 肝硬変患者に対する診断的アプローチ diagnostic approach to the patient with cirrhosis
• 4. アルコール性肝疾患の病因 pathogenesis of alcoholic liver disease
• 5. 肝疾患患者における凝固異常 coagulation abnormalities in patients with liver disease

English Journal

• Chronic hepatitis E virus infection after living donor liver transplantation via blood transfusion: a case report.

• Kurihara T1, Yoshizumi T2, Itoh S1, Harimoto N1, Harada N1, Ikegami T1, Inagaki Y3, Oshiro Y3, Ohkohchi N3, Okamoto H4, Maehara Y1.
• Surgical case reports.Surg Case Rep.2016 Dec;2(1):32. doi: 10.1186/s40792-016-0159-0. Epub 2016 Apr 8.
• Although it occurs worldwide, hepatitis E virus (HEV) infection in developed countries is generally foodborne. HEV infection is subclinical in most individuals. Although fulminant liver failure may occur, progression to chronic hepatitis is rare. This study describes a 41-year-old man with liver cir
• PMID 27059470

• Contrast-enhanced ultrasonography could be a non-invasive method for differentiating none or mild from severe fibrosis in patients with biopsy proven non-alcoholic fatty liver disease.

• Nasr P1, Hilliges A1, Thorelius L1, Kechagias S1, Ekstedt M1.
• Scandinavian journal of gastroenterology.Scand J Gastroenterol.2016 Sep;51(9):1126-1132. Epub 2016 May 10.
• OBJECTIVE: The gold standard for diagnosing fibrosis stage in non-alcoholic fatty liver disease (NAFLD) is liver biopsy. The aim of this study was to determine whether contrast-enhanced ultrasonography (CEUS) with transit time measurements could be a non-invasive alternative for differentiating none
• PMID 27161854

• Management of Neurologic Manifestations in Patients with Liver Disease.

• Ferro JM1,2, Viana P3, Santos P4.
• Current treatment options in neurology.Curr Treat Options Neurol.2016 Aug;18(8):37.
• OPINION STATEMENT: Liver disease, both in its acute and chronic forms, can be associated with a wide spectrum of neurologic manifestations, both central and peripheral, ranging in severity from subclinical changes to neurocritical conditions. Neurologists are frequently consulted to participate in t
• PMID 27314429

Japanese Journal

• 症例 アルコール性肝硬変に合併した侵襲性肺アスペルギルス症の1剖検例

• 日本呼吸器学会誌 = Annals of the Japanese Respiratory Society 4(5), 398-402, 2015-09-10
• NAID 40020592914

• 症例報告 当院で経験した十二指腸静脈瘤破裂の4症例

• 山口医学 = Yamaguchi medical journal 64(2), 145-152, 2015-05
• NAID 120005617816

• 肝硬変に伴う夜盲症に対して亜鉛とビタミンA製剤の静脈内投与を行った1例

• 眼科臨床紀要 8(3), 145-150, 2015
• NAID 40020392235

Related Links

• Alcoholic liver disease: MedlinePlus Medical Encyclopedia

Alcoholic liver disease occurs after years of heavy drinking. Over time, scarring and cirrhosis can occur. Cirrhosis is the final phase of alcoholic liver disease. Alcoholic liver disease does not occur in all heavy drinkers. The ...

• Cirrhosis - National Library of Medicine - PubMed Health

Evidence reviews Transient Elastography with Suspected Fibrosis and Cirrhosis of the Liver [Internet] Evidence supporting colchicine for alcoholic, viral, and cryptogenic liver fibrosis/cirrhosis is still lacking Alcohol and hepatotropic ...

Related Pictures

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★リンクテーブル★

リンク元	「アルコール性肝硬変」
関連記事	「alcoholic」「alcoholics」「live」「cirrhosis」「alcohol」

「アルコール性肝硬変」

　　[★]

英

alcoholic liver cirrhosis、alcoholic cirrhosis

関

アルコール性肝障害、肝硬変

身体所見

• 肝臓：腫大した肝臓を触れる

「alcoholic」

　　[★]

holic …中毒の人

• adj.

• アルコールの。アルコール性の。アルコール含有の。アルコール漬けの。アルコール腫による。アルコール中毒の

• n.

• 大酒飲み、アルコール中毒者。アルコール漬け標本

関

alcohol、alcoholics、alcoholism

　 　 　 　

「alcoholics」

　　[★]

• n

• アルコール中毒者、アルコール依存患者

関

alcoholic

関

also Fetal alcohol syndrome

「live」

　　[★]

[liv]

• vt.
• vi.

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[laiv]

• adj.

同

LAIV

　 　 　 　 　 　 　 　 　 　 　 　

「cirrhosis」

　　[★]

cirrho(=tawny yellow)

• n.

• 肝硬変

　 　

「alcohol」

　　[★] アルコール

関

ethanol