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Alclometasone
|
Clinical data |
Trade names |
Aclovate |
AHFS/Drugs.com |
Monograph |
MedlinePlus |
a604021 |
Routes of
administration |
topical |
ATC code |
D07AB10 (WHO) S01BA10 (WHO) |
Legal status |
Legal status |
|
Identifiers |
IUPAC name
- [7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
|
CAS Number |
66734-13-2 Y |
PubChem (CID) |
5311000 |
DrugBank |
DB00240 Y |
ChemSpider |
4470541 Y |
UNII |
136H45TB7B Y |
KEGG |
D01820 Y |
ChEBI |
CHEBI:53776 Y |
ChEMBL |
CHEMBL1201361 N |
ECHA InfoCard |
100.060.403 |
Chemical and physical data |
Formula |
C28H37ClO7 |
Molar mass |
521.042 g/mol |
3D model (Jmol) |
Interactive image |
SMILES
-
O=C\1\C=C/[C@]4(/C(=C/1)C[C@@H](Cl)[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)[C@@H](C[C@@H]23)C)C)C
|
InChI
-
InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1 Y
-
Key:FJXOGVLKCZQRDN-PHCHRAKRSA-N Y
|
NY (what is this?) (verify) |
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
The prodrug alclometasone dipropionate is marketed as Aclovate by GlaxoSmithKline.
Contents
- 1 Pharmacology
- 2 Indications
- 3 Contraindications
- 4 Side effects
- 5 How supplied
Pharmacology
Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).
Indications
Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:
- atopic dermatitis
- eczema
- psoriasis
- allergic dermatitis
- contact dermatitis
- actinic dermatitis
- kiss-type allergy
- skin itch
Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.
Contraindications
- hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
- cutaneous tuberculosis
- chicken pox
- perioral dermatitis
- acne
- rosacea
- open wounds
- trophic ulcers
- viral infection of skin
- skin manifestations of syphilis
Side effects
Adverse reactions (sometimes, less than 1-2% cases) include:
- burning
- itching
- erythema
- skin reddening
- xerodermia
- skin irritation
- acne
- hypopigmentation
- prickly heat
- folliculitis
- white atrophy
- hypertrichosis
- reinfection of skin
How supplied
Alclometasone as Aclovate is supplied in:
- Cream; Topical; 0.05%
- Ointment; Topical; 0.05%
Glucocorticoids and antiglucocorticoids (H02)
|
|
Glucocorticoids |
Natural |
- Cortisone
- Cortodoxone (cortexolone, 11-deoxycortisol)
- Desoxycortone (deoxycortone, cortexone, 11-deoxycorticosterone)
- Hydrocortisone (cortisol)#
- Hydrocortisone aceponate
- Hydrocortisone buteprate
- Hydrocortisone butyrate
|
|
Synthetic |
- Progesterone-type: Flugestone acetate (flurogestone acetate)
- Fluorometholone
- Medrysone
- Prebediolone acetate
- Pregnenolone
- Pregnenolone acetate
- Pregnenolone succinate
- Hydrocortisone-type: Chloroprednisone
- Cloprednol
- Difluprednate
- Fludrocortisone
- Fluocinolone
- Fluperolone
- Fluprednisolone
- Loteprednol
- Methylprednisolone
- Methylprednisolone aceponate
- Methylprednisolone acetate
- Methylprednisolone suleptanate
- Prednicarbate
- Prednisolone
- Prednisone
- Tixocortol
- Triamcinolone
- Methasone-type (16-methylated): Alclometasone
- Beclometasone
- Beclometasone dipropionate
- Betamethasone
- Betamethasone dipropionate
- Clobetasol
- Clobetasone
- Clocortolone
- Cortivazol
- Desoximetasone
- Dexamethasone
- Dexamethasone acefurate
- Dexamethasone isonicotinate
- Diflorasone
- Difluocortolone
- Fluclorolone
- Flumetasone
- Fluocortin
- Fluocortolone
- Fluprednidene
- Fluticasone
- Halometasone
- Meprednisone
- Mometasone
- Paramethasone
- Prednylidene
- Rimexolone
- Ulobetasol (halobetasol)
- Acetonides and related: Amcinonide
- Budesonide
- Ciclesonide
- Deflazacort
- Desonide
- Formocortal (fluoroformylone)
- Fluclorolone acetonide (flucloronide)
- Fludroxycortide (flurandrenolone, flurandrenolide)
- Flunisolide
- Fluocinolone acetonide
- Fluocinonide
- Fluticasone furoate
- Halcinonide
- Mometasone furoate
- Triamcinolone acetonide
- Triamcinolone benetonide
- Triamcinolone furetonide
- Triamcinolone hexacetonide
|
|
|
Antiglucocorticoids |
- SGRMs: Dagrocorat§
- Fosdagrocorat§
- Mapracorat†
- Antagonists: Ketoconazole
- Mifepristone
|
|
Synthesis modifiers |
- Acetoxolone
- Aminoglutethimide
- Carbenoxolone
- Enoxolone
- Ketoconazole
- Metyrapone
- Mitotane
- Trilostane
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
See also: Androgens and antiandrogens • Estrogens and antiestrogens • Progestogens and antiprogestogens • Mineralocorticoids and antimineralocorticoids
|
Glucocorticoid receptor modulators
|
|
GR |
Agonists
|
|
|
Mixed (SEGRAs)
|
- Dagrocorat
- Fosdagrocorat
- Mapracorat
|
|
Antagonists
|
- 7α-Hydroxy-DHEA
- 17α-Methylprogesterone
- Aglepristone
- Asoprisnil
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Formebolone
- Guggulsterone
- Ketoconazole
- Lilopristone
- LLY-2707
- Miconazole
- Mifepristone
- Onapristone
- ORG-34116
- ORG-34517 (SCH-900636)
- ORG-34850
- Pregnenolone 16α-carbonitrile
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
|
|
|
See also: Androgenics • Estrogenics • Mineralocorticoidics • Progestogenics • Steroid hormone metabolism modulators
|
UpToDate Contents
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English Journal
- A potent steroid cream is superior to emollients in reducing acute radiation dermatitis in breast cancer patients treated with adjuvant radiotherapy. A randomised study of betamethasone versus two moisturizing creams.
- Ulff E1, Maroti M, Serup J, Falkmer U.
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.Radiother Oncol.2013 Aug;108(2):287-92. doi: 10.1016/j.radonc.2013.05.033. Epub 2013 Jul 2.
- BACKGROUND AND PURPOSE: The aim was to investigate whether treatment with potent local steroids can reduce signs and symptoms of acute radiation dermatitis in breast cancer patients undergoing adjuvant radiotherapy (RT) compared to emollient creams.MATERIAL AND METHODS: The study was randomised and
- PMID 23827771
- A 12-year-old boy with foot lesions.
- Zimmerman B1, Chamlin SL.
- Pediatric annals.Pediatr Ann.2013 Jan;42(1):11-2. doi: 10.3928/00904481-20121221-12.
- CME EDUCATIONAL OBJECTIVES: 1.Identify the clinical presentation of granuloma annulare.2.Describe the differential diagnosis for granuloma annulare.3.Discuss the appropriate management for granuloma annulare. A 12-year-old healthy male presented to the dermatology clinic for evaluation of lesions on
- PMID 23316825
Japanese Journal
- 山本 佳久,深水 啓朗,小出 達夫
- 製剤機械技術学会誌 = Journal of pharmaceutical machinery and engineering 22(2), 94-99, 2013
- NAID 40019754570
- 仁井谷 暁子,藤本 亘
- 西日本皮膚科 71(5), 474-478, 2009
- 31歳の女性が眼囲炎に酪酸プロピオン酸ベタメタゾン(アンテベート<SUP>®</SUP>)軟膏, プロピオン酸アルクロメタゾン(アルメタ<SUP>®</SUP>)軟膏を外用し紅斑を生じた。患者は過去に吉草酸ベタメタゾン(リンデロン<SUP>®</SUP>VG)軟膏・クリームによると思われる接触皮膚炎に対し, ベタメタゾン(リン …
- NAID 130004475327
- 症例 プロピオン酸アルクロメタゾンによる接触皮膚炎の1例
Related Links
- Alclometasone Dipropionate reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). ... Alclometasone Dipropionate Pharmacokinetics Absorption Bioavailability Topically ...
- Alclometasone official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. ... Overdosage Topically applied Alclometasone dipropionate cream and ointment ...
Related Pictures
★リンクテーブル★
[★]
- 英
- alclometasone、
- 商
- アルメタ、タルメア、ビトラ
- 関
- プロピオン酸アルクロメタゾン alclometasone propionate、ジプロピオン酸アルクロメタゾン alclometasone dipropionate
[★]
- 英
- alclometasone dipropionate
- 関
- アルクロメタゾン、ジプロピオン酸アルクロメタゾン
[★]
- 英
- alclometasone dipropionate
- 関
- アルクロメタゾン、プロピオン酸アルクロメタゾン
[★]
- 関
- alclometasone dipropionate
[★]
二プロピオン酸、(化合物)二プロピオン酸塩
[★]
アルクロメタゾン
- 関
- alclometasone dipropionate