関: alclometasone dipropionate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/14 23:03:45」(JST)

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Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.

The prodrug alclometasone dipropionate is marketed as Aclovate by GlaxoSmithKline.

Pharmacology

Alclometasone inhibits phospholipase A2 by inducing production of lipocortins; inhibits synthesis of arachidonic acid, prostaglandins and leukotrienes acid, reduce release of cytokines from lymphocytes and others mediators of inflammation (incl. histamine).

Indications

Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:

atopic dermatitis
eczema
psoriasis
allergic dermatitis
contact dermatitis
actinic dermatitis
kiss-type allergy
skin itch

Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

Contraindications

hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
cutaneous tuberculosis
chicken pox
perioral dermatitis
acne
rosacea
open wounds
trophic ulcers
viral infection of skin
skin manifestations of syphilis

Side effects

Adverse reactions (sometimes, less than 1-2% cases) include:

burning
itching
erythema
skin reddening
xerodermia
skin irritation
acne
hypopigmentation
prickly heat
folliculitis
white atrophy
hypertrichosis
reinfection of skin

How supplied

Alclometasone as Aclovate is supplied in:

Cream; Topical; 0.05%
Ointment; Topical; 0.05%

UpToDate Contents

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English Journal

A potent steroid cream is superior to emollients in reducing acute radiation dermatitis in breast cancer patients treated with adjuvant radiotherapy. A randomised study of betamethasone versus two moisturizing creams.

Ulff E1, Maroti M, Serup J, Falkmer U.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.Radiother Oncol.2013 Aug;108(2):287-92. doi: 10.1016/j.radonc.2013.05.033. Epub 2013 Jul 2.
BACKGROUND AND PURPOSE: The aim was to investigate whether treatment with potent local steroids can reduce signs and symptoms of acute radiation dermatitis in breast cancer patients undergoing adjuvant radiotherapy (RT) compared to emollient creams.MATERIAL AND METHODS: The study was randomised and
PMID 23827771

A 12-year-old boy with foot lesions.

Zimmerman B1, Chamlin SL.
Pediatric annals.Pediatr Ann.2013 Jan;42(1):11-2. doi: 10.3928/00904481-20121221-12.
CME EDUCATIONAL OBJECTIVES: 1.Identify the clinical presentation of granuloma annulare.2.Describe the differential diagnosis for granuloma annulare.3.Discuss the appropriate management for granuloma annulare. A 12-year-old healthy male presented to the dermatology clinic for evaluation of lesions on
PMID 23316825

Pharmaceutical evaluation of steroidal ointments by ATR-IR chemical imaging: distribution of active and inactive pharmaceutical ingredients.

Yamamoto Y1, Fukami T, Koide T, Suzuki T, Hiyama Y, Tomono K.
International journal of pharmaceutics.Int J Pharm.2012 Apr 15;426(1-2):54-60. doi: 10.1016/j.ijpharm.2012.01.017. Epub 2012 Jan 20.
We recently used micro attenuated total reflection infrared (ATR-IR) spectroscopy to conduct imaging analysis of ointments and evaluate the distributions of the active pharmaceutical ingredient (API) and excipients. An alclometasone dipropionate (ALC) ointment was used as a model product. Almeta, a
PMID 22286017

Japanese Journal

液滴分散型軟膏の顕微ATR-IRイメージング

山本佳久,深水啓朗,小出達夫
製剤機械技術学会誌 = Journal of pharmaceutical machinery and engineering 22(2), 94-99, 2013
NAID 40019754570

ステロイド外用剤によるアレルギー性接触皮膚炎

仁井谷暁子,藤本亘
西日本皮膚科 71(5), 474-478, 2009
31歳の女性が眼囲炎に酪酸プロピオン酸ベタメタゾン(アンテベート®)軟膏, プロピオン酸アルクロメタゾン(アルメタ®)軟膏を外用し紅斑を生じた。患者は過去に吉草酸ベタメタゾン(リンデロン®VG)軟膏・クリームによると思われる接触皮膚炎に対し, ベタメタゾン(リン …
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皮膚科の臨床 49(6), 711-714, 2007-06
NAID 40015517835

Related Pictures

★リンクテーブル★

リンク元	「アルクロメタゾン」
拡張検索	「alclometasone propionate」

「アルクロメタゾン」

Alclometasone
Systematic (IUPAC) name
	[7-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-propanoyloxyacetyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
Clinical data
Trade names	Aclovate
AHFS/Drugs.com	monograph
MedlinePlus	a604021
Legal status	Rx Only (US);
Routes	topical
Identifiers
CAS number	66734-13-2
ATC code	D07AB10 S01BA10
PubChem	CID 5311000
DrugBank	DB00240
ChemSpider	4470541
UNII	136H45TB7B
KEGG	D01820
ChEBI	CHEBI:53776
ChEMBL	CHEMBL1201361
Chemical data
Formula	C28H37ClO7
Molecular mass	521.042 g/mol
	SMILES O=C\1\C=C/[C@]4(/C(=C/1)C[C@@H](Cl)[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@](O)(C(=O)CO)[C@@H](C[C@@H]23)C)C)C;
	InChI InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1 ; Key:FJXOGVLKCZQRDN-PHCHRAKRSA-N ;
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