WordNet

very young; "at an early age"
before the usual time or the time expected; "she graduated early"; "the house was completed ahead of time" (同)ahead of time, too soon
in good time; "he awoke betimes that morning" (同)betimes
belonging to the distant past; "the early inhabitants of Europe"; "former generations"; "in other times" (同)former, other
at or near the beginning of a period of time or course of events or before the usual or expected time; "early morning"; "an early warning"; "early diagnosis"; "an early death"; "took early retirement"; "an early spring"; "early varieties of peas and tomatoes mature before most standard varieties"
being or occurring at an early stage of development; "in an early stage"; "early forms of life"; "early man"; "an early computer"
expected in the near future; "look for an early end to the negotiations"
of an early stage in the development of a language or literature; "the Early Hebrew alphabetical script is that used mainly from the 11th to the 6th centuries B.C."; "Early Modern English is represented in documents printed from 1476 to 1700"
fruiting spike of a cereal plant especially corn (同)spike, capitulum
attention to what is said; "he tried to get her ear"
good hearing; "he had a keen ear"; "a good ear for pitch"
the sense organ for hearing and equilibrium
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
any of a group of viruses including those that in humans cause upper respiratory infections or infectious pinkeye
a British peer ranking below a marquess and above a viscount

PrepTutorEJDIC

(時間・時期が)『早い』,『初期の』 / 昔の / (普通より,予定より)早い / 近い将来の / (時間・時期的に)『早く』 / (予定・ふだんより)早く
〈C〉『耳』 / 《単数形で》『聴覚』,聴力,音感 / 《単数形で》じっと聞くこと,傾聴 / 〈C〉耳の形をした物
(麦・とうもろこしなどの)穂
蛋白(たんばく)質
(英国の)伯爵

UpToDate Contents

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1. アデノウイルス感染の疫学および臨床症状 epidemiology and clinical manifestations of adenovirus infection
2. アデノウイルス感染の診断、治療、および予防 diagnosis treatment and prevention of adenovirus infection
3. アデノウイルスの病因およびベクター使用 adenovirus pathogenesis and vector applications
4. 小児および思春期における急性感染性咽頭炎の診断へのアプローチ approach to diagnosis of acute infectious pharyngitis in children and adolescents
5. 前立腺癌の分子生物学 molecular biology of prostate cancer

English Journal

Neutrophil elastase and its therapeutic effect on leukemia cells.

Jiang KL1, Ma PP1, Yang XQ2, Zhong L2, Wang H2, Zhu XY2, Liu BZ1.
Molecular medicine reports.Mol Med Rep.2015 Sep;12(3):4165-72. doi: 10.3892/mmr.2015.3946. Epub 2015 Jun 17.
Neutrophil elastase (NE) is an early myeloid-specific serine protease, which is predominantly produced by promyelocytes. A previous study demonstrated that NE has an important role in the development of acute promyelocytic leukemia (APL). The process of APL was shown to be accelerated in animals tha
PMID 26081156

The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters.

Lo Cigno I1, De Andrea M2, Borgogna C1, Albertini S1, Landini MM2, Peretti A1, Johnson KE3, Chandran B3, Landolfo S4, Gariglio M5.
Journal of virology.J Virol.2015 Aug 1;89(15):7506-20. doi: 10.1128/JVI.00013-15. Epub 2015 May 13.
The human interferon-inducible IFI16 protein, an innate immune sensor of intracellular DNA, was recently demonstrated to act as a restriction factor for human cytomegalovirus (HCMV) and herpes simplex virus 1 (HSV-1) infection by inhibiting both viral-DNA replication and transcription. Through the u
PMID 25972554

Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210.

Frank B1, Marcu A2, de Oliveira Almeida Petersen AL3,4, Weber H5, Stigloher C6, Mottram JC7, Scholz CJ8, Schurigt U9.
Parasites & vectors.Parasit Vectors.2015 Jul 31;8:404. doi: 10.1186/s13071-015-0974-3.
BACKGROUND: Autophagy participates in innate immunity by eliminating intracellular pathogens. Consequently, numerous microorganisms have developed strategies to impair the autophagic machinery in phagocytes. In the current study, interactions between Leishmania major (L. m.) and the autophagic machi
PMID 26226952

Japanese Journal

The Small Heat Shock Protein αB-Crystallin Inhibits Differentiation-Induced Caspase 3 Activation and Myogenic Differentiation

IKEDA Ryuji,YOSHIDA Kenichi,USHIYAMA Mina,YAMAGUCHI Tatsuya,IWASHITA Ken-ichi,FUTAGAWA Toshitaka,SHIBAYAMA Yoshihiko,OISO Shigeru,TAKEDA Yasuo,KARIYAZONO Hiroko,FURUKAWA Tatsuhiko,NAKAMURA Kazuo,AKIYAMA Shin-ichi,INOUE Ituro,YAMADA Katsushi
Biological & pharmaceutical bulletin 29(9), 1815-1819, 2006-09-01
… Here we demonstrate that the expression of the small heat shock protein αB-crystallin as well as MyoD and myogenin is induced during myogenic differentiation in C2C12 cells, and these inductions occur at an early stage in the differentiation in vitro. … To investigate the effect of αB-crystallin on myogenic differentiation and apoptosis, C2C12 cells were infected with adenovirus vector bearing full-length αB-crystallin cDNA. …
NAID 110005602343

Expression of Adenovirus Type 5 E1A in the Methylotrophic Yeast Pachia pastoris and the Inhibitory Effect on S-180 Tumor Growth

MA Yewei,ZHOU Xiaoshan,ZHAO Qingzheng,LI Yanchun,LIU Yuying,WANG Zheng,ZHANG Yangpei
Biological & pharmaceutical bulletin 26(2), 137-140, 2003-02-01
… The human adenovirus type 5 (Ad5) early-region 1A (E1A) proteins have been shown to have strong tumor-suppressive activities in human tumor cells and to enhance the sensitivity of a variety of malignant tumors to apoptosis induced by ionizing radiation and chemotherapeutic agents. … This prompted us to construct an E1A expression vector (pPIC9/E1A) and express the E1A protein in the methylotrophic yeast Pichia pastoris. …
NAID 110003608391

The novel early region 3 protein E 3/49 K is specifically expressed by adenoviruses of subgenus D : implications for epidemic keratoconjunctivitis and adenovirus evolution