WordNet

an oral antiviral drug (trade name Zovirax) used to treat genital herpes; does not cure the disease but relieves the symptoms (同)Zovirax

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1. アシクロビル：概要 acyclovir an overview
2. HIV感染患者における薬剤抵抗性性器単純ヘルペスウイルス感染の治療 treatment of drug resistant genital herpes simplex virus infection in hiv infected patients
3. バラシクロビル：概要 valacyclovir an overview
4. 免疫正常患者における単純ヘルペスウイルス1型感染の防止 prevention of herpes simplex virus type 1 infection in immunocompetent patients
5. ファムシクロビル：概要 famciclovir an overview

Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses.

McMahon MA, Parsons TL, Shen L, Siliciano JD, Siliciano RF.SourceDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Journal of virology.J Virol.2011 May;85(9):4618-22. doi: 10.1128/JVI.02423-10. Epub 2011 Feb 16.
Acyclovir, a nucleoside analog, is thought to be specific for the human herpesviruses because it requires a virally encoded enzyme to phosphorylate it to acyclovir monophosphate. Recently, acyclovir triphosphate was shown to be a direct inhibitor of human immunodeficiency virus type 1 (HIV-1) revers
PMID 21325417

The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation.

McMahon MA, Siliciano JD, Lai J, Liu JO, Stivers JT, Siliciano RF, Kohli RM.SourceDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
The Journal of biological chemistry.J Biol Chem.2008 Nov 14;283(46):31289-93. doi: 10.1074/jbc.C800188200. Epub 2008 Sep 24.
The antiviral drug acyclovir is a guanosine nucleoside analog that potently inhibits herpes simplex virus (HSV) replication. Acyclovir treatment in patients coinfected with HSV and human immunodeficiency virus (HIV) has been observed to alter disease course and decrease HIV viral load, a finding tha
PMID 18818198

Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.

Hanes JW, Zhu Y, Parris DS, Johnson KA.SourceDepartment of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, The University of Texas, Austin, Texas 78712, USA.
The Journal of biological chemistry.J Biol Chem.2007 Aug 24;282(34):25159-67. Epub 2007 Jun 14.
We have examined the kinetics of incorporation of acyclovir triphosphate by the herpes simplex virus-1 DNA polymerase holoenzyme (Pol-UL42) and the human mitochondrial DNA polymerase using transient kinetic methods. For each enzyme, we compared the kinetic parameters for acyclovir to those governing
PMID 17573351

林利光
藥學雜誌 128(1), 61-79, 2008-01-01
… Scopadulciol (SDC), isolated from the tropical medicinal plant Scoparia dulcis L., showed stimulatory effects on the antiviral potency of acyclovir (ACV) or ganciclovir (GCV). … This effect of SDC was exerted via the activation of viral thymidine kinase (HSV-1 TK) and, as a result, an increase in the cellular concentration of the active form of ACV/GCV, i.e., the triphosphate of ACV or GCV. …
NAID 110006533004

Acyclovir triphosphate inhibits the diagnostic polymerase chain reaction for cytomegalovirus

Effects of Acyclovir, Oxetanocin-G, and Carbocyclic Oxetanocin-G in Combinations on the Replications of Herpes Simplex Virus Type 1 and Type 2 in Vero Cells.

SAIJO MASAYUKI,SUZUTANI TATSUO,YOSHIDA ITSURO
The Tohoku Journal of Experimental Medicine 167(1), 57-68, 1992
… Effects of Acyclovir, Oxetanocin-G, and Carbocyclic Oxetanocin-G in Combinations on the Replications of Herpes Simplex Virus Type 1 and Type 2 in Vero Cells. …
NAID 130003494443