WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
肺の;肺を冒す

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1. 肺ヒストプラスマ症の診断および治療 diagnosis and treatment of pulmonary histoplasmosis
2. 肺ヒストプラスマ症の病因および臨床的特徴 pathogenesis and clinical features of pulmonary histoplasmosis
3. HIVに感染していない患者の播種性ヒストプラスマ症の診断と治療 diagnosis and treatment of disseminated histoplasmosis in hiv uninfected patients
4. 播種性ヒストプラスマ症の病因および臨床症状 pathogenesis and clinical manifestations of disseminated histoplasmosis
5. 中南米諸国やカリブ海地域への旅行者にみられる疾患への治療アプローチ approach to illness associated with travel to latin america and the caribbean

Hage CA1, Azar MM2, Bahr N3, Loyd J4, Wheat LJ5.
Seminars in respiratory and critical care medicine.Semin Respir Crit Care Med.2015 Oct;36(5):729-45. doi: 10.1055/s-0035-1562899. Epub 2015 Sep 23.
Histoplasmosis is the most common endemic mycosis in the North America, Central America, and many countries of South America and also occurs in China, India, Southeast Asia, Africa, Australia, and Europe. Clinical syndromes are not specific and histoplasmosis often is overlooked in the evaluation of
PMID 26398539

Hepatic Failure in a Patient Receiving Itraconazole for Pulmonary Histoplasmosis-Case Report and Literature Review.

Pettit NN1, Pisano J, Weber S, Ridgway J.
American journal of therapeutics.Am J Ther.2015 Aug 18. [Epub ahead of print]
Severe cases of itraconazole-induced hepatotoxicity have been reported; however, these events are thought to occur very rarely. The available literature is comprised largely of individual case reports and small series that do not report the itraconazole serum concentration at the time of the severe
PMID 26291595

A diagnostic predicament: activated sarcoidosis or pulmonary histoplasmosis. A case report.

Lingscheid T1, von Heinz M1, Klages B1, Rickerts V2, Tintelnot K2, Gerhold M3, Oestmann JW4, Becker M1, Temmesfeld-Wollbrück B1, Suttorp N1, Hübner RH1.
The clinical respiratory journal.Clin Respir J.2015 Jul 6. doi: 10.1111/crj.12344. [Epub ahead of print]
We report a case of a 41-year-old man presenting with persisting fevers over 2 weeks. The patient had spent 4 weeks in Central America. He was in control of a stable stage II sarcoidosis. Laboratory and various microbiological tests as well as chest radiography led to no diagnosis. Activated sarcoid
PMID 26152858