WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
characteristic of or containing alcohol; "alcoholic drinks"
a person who drinks alcohol to excess habitually (同)alky, dipsomaniac, boozer, lush, soaker, souse
addicted to alcohol; "alcoholic expatriates in Paris"- Carl Van Doren (同)alcohol-dependent
any of a series of volatile hydroxyl compounds that are made from hydrocarbons by distillation
a liquor or brew containing alcohol as the active agent; "alcohol (or drink) ruined him" (同)alcoholic drink, alcoholic_beverage, intoxicant, inebriant
inflammation of the liver caused by a virus or a toxin

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
アルコールの,アルコール性の / アルコールのはいった;アルコール漬けの / アルコール中毒の / アルコール中毒[患]者
『アルコール』,酒精 / 『アルコール飲料』,酒
肝[臓]炎

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Spengler EK1, Dunkelberg J, Schey R.
Digestive diseases and sciences.Dig Dis Sci.2014 May 6. [Epub ahead of print]
Alcoholic hepatitis is an acute manifestation of alcoholic liver disease with mortality as high as 40-50 % in severe cases. Patients usually have a history of prolonged alcohol abuse with or without a known history of liver disease. Although there is significant range in severity at presentation, p
PMID 24798996

Xu R1, Huang H2, Zhang Z1, Wang FS1.
Cellular & molecular immunology.Cell Mol Immunol.2014 May;11(3):224-31. doi: 10.1038/cmi.2014.2. Epub 2014 Mar 17.
Liver disease encompasses a wide variety of liver conditions, including liver failure, liver cirrhosis and a spectrum of acute and chronic hepatitis, such as alcoholic, fatty, drug, viral and chronic hepatitis. Liver injury is a primary causative factor in liver disease; generally, these factors inc
PMID 24633014

Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis.

Mukhopadhyay P1, Rajesh M, Cao Z, Horváth B, Park O, Wang H, Erdelyi K, Holovac E, Wang Y, Liaudet L, Hamdaoui N, Lafdil F, Haskó G, Szabo C, Boulares AH, Gao B, Pacher P.
Hepatology (Baltimore, Md.).Hepatology.2014 May;59(5):1998-2009. doi: 10.1002/hep.26763. Epub 2014 Apr 1.
Poly (ADP-ribose) polymerase 1 (PARP-1) is a constitutive enzyme, the major isoform of the PARP family, which is involved in the regulation of DNA repair, cell death, metabolism, and inflammatory responses. Pharmacological inhibitors of PARP provide significant therapeutic benefits in various precli
PMID 24089324