WordNet

strike suddenly and with force; "This show zaps the viewers with some shocking scenes"
a sudden event that imparts energy or excitement, usually with a dramatic impact; "they gave it another zap of radiation"
kill with or as if with a burst of gunfire or electric current or as if by shooting; "in this computer game, space travellers are vaporized by aliens" (同)vaporize
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 26th letter of the Roman alphabet; "the British call Z zed and the Scots call it ezed but Americans call it zee"; "he doesnt know A from izzard" (同)z, zee, zed, ezed, izzard
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
an amino acid found in most proteins; a precursor of several hormones

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Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.

Kumar L1, Chou J, Yee CS, Borzutzky A, Vollmann EH, von Andrian UH, Park SY, Hollander G, Manis JP, Poliani PL, Geha RS.
The Journal of experimental medicine.J Exp Med.2014 May 5;211(5):929-42. doi: 10.1084/jem.20131379. Epub 2014 Apr 21.
Lrrc8a is a ubiquitously expressed gene that encodes a leucine-rich repeat (LRR)-containing protein detected at higher levels on the surface of thymocytes than on other immune cells. We generated Lrrc8a(-/-) mice to investigate the role of LRRC8A in lymphocyte development and function. Lrrc8a(-/-) m
PMID 24752297

A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.

Siggs OM1, Yates AL, Schlenner S, Liston A, Lesage S, Goodnow CC.
Immunology.Immunology.2014 Apr;141(4):587-95. doi: 10.1111/imm.12220.
Quantitative reductions in T-cell receptor (TCR) signalling are associated with severe immunodeficiency, yet in certain cases can lead to autoimmunity. Mutation of the tyrosine kinase ZAP-70 can cause either of these outcomes, yet the limits of its signal transducing capacity are not well defined. T
PMID 24266404

Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.

Yu X1, Almeida JR2, Darko S2, van der Burg M3, DeRavin SS4, Malech H4, Gennery A5, Chinn I6, Markert ML7, Douek DC8, Milner JD9.
The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2014 Apr;133(4):1109-15. doi: 10.1016/j.jaci.2013.11.018. Epub 2014 Jan 7.
BACKGROUND: Human immunodeficiencies characterized by hypomorphic mutations in critical developmental and signaling pathway genes allow for the dissection of the role of these genes in the development of the T-cell receptor (TCR) repertoire and the correlation of alterations of the TCR repertoire wi
PMID 24406074