WordNet

a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
German art historian (1866-1929) (同)Aby Warburg, Aby Moritz Warburg
German biochemist who pioneered the use of chemical techniques in biological investigations; noted for studies of cellular respiration (1883-1970) (同)Otto Heinrich Warburg

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(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/11 21:54:14」(JST)

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Walker–Warburg syndrome (WWS), also called Warburg syndrome, Chemke syndrome, HARD syndrome (Hydrocephalus, Agyria and Retinal Dysplasia), Pagon syndrome, cerebroocular dysgenesis (COD) or cerebroocular dysplasia-muscular dystrophy syndrome (COD-MD),^[1] is a rare form of autosomal recessive congenital muscular dystrophy.^[2] It is associated with brain (lissencephaly, hydrocephalus, cerebellar malformations) and eye abnormalities. This condition has a worldwide distribution. The overall incidence is unknown but a survey in North-eastern Italy has reported an incidence rate of 1.2 per 100,000 live births. It is the most severe form of congenital muscular dystrophy with most children dying before the age of three years.

Characteristics[edit]

The clinical manifestations present at birth are generalized hypotonia, muscle weakness, developmental delay with mental retardation and occasional seizures. The congenital muscular dystrophy is characterized by hypoglycosylation of α-dystroglycan. Those born with the disease also experience severe ocular and brain defects. Half of all children with WWS are born with encephalocele, which is a gap in the skull that will not seal. The meninges of the brain protrude through this gap due to the neural tube failing to close during development. A malformation of the a baby's cerebellum is often a sign of this disease.Common ocular issues associated with WWS are abnormally small eyes and retinal abnormalities cause by an underdeveloped light-sensitive area in the back of the eye. ^[3]

Cause and Genetics[edit]

Walker–Warburg syndrome has an autosomal recessive pattern of inheritance.

Several genes have been implicated in the etiology of Walker–Warburg syndrome,^[4] and others are as yet unknown. Several mutations were found in the protein O-Mannosyltransferase POMT1 and POMT2 genes, and one mutation was found in each of the fukutin and fukutin-related protein genes.

Diagnosis[edit]

Laboratory investigations usually show elevated creatine kinase, myopathic/dystrophic muscle pathology and altered α-dystroglycan. Antenatal diagnosis is possible in families with known mutations. Prenatal ultrasound may be helpful for diagnosis in families where the molecular defect is unknown.

Prognosis[edit]

No specific treatment is available. Management is only supportive and preventive. Those who are diagnosed with the disease often die within the first few months of life. Almost all children with the disease die by the age of three. ^[5]

Eponym[edit]

WWS is named for Arthur Earl Walker and Mette Warburg (1923- ), a Danish Ophthalmologist.^[6]^[7]^[8] Its alternative names include Chemke’s syndrome and Pagon’s syndrome; named after Juan M. Chemke and Roberta A. Pagon.^[9]

References[edit]

^ Online 'Mendelian Inheritance in Man' (OMIM) 236670
^ Vajsar J, Schachter H (2006). "Walker–Warburg syndrome". Orphanet J Rare Dis 1: 29. doi:10.1186/1750-1172-1-29. PMC 1553431. PMID 16887026.
^ Weiss, Thomas C.. "Walker-Warburg Syndrome - Facts and Information." Disabled World. N.p., 6 Mar. 2010. Web. 8 Dec. 2013. <http://www.disabled-world.com/disability/types/mobility/md/walker-warburg.php>.
^ Beltrán-Valero de Bernabé D, Currier S, Steinbrecher A, et al. (November 2002). "Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker–Warburg syndrome". Am. J. Hum. Genet. 71 (5): 1033–43. doi:10.1086/342975. PMC 419999. PMID 12369018.
^ Vajsar, Jiri, and Harry Schachter. "Abstract." National Center for Biotechnology Information. U.S. National Library of Medicine, 3 Aug. 2006. Web. 8 Dec. 2013. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1553431/?report=classic>.
^ synd/1202 at Who Named It?
^ Walker AE (1942). "Lissencephaly". Archives of Neurology and Psychiatry (Chicago) 48: 13–29.
^ Warburg M (March 1971). "The heterogeneity of microphthalmia in the mentally retarded". Birth Defects Orig. Artic. Ser. 7 (3): 136–54. PMID 4950916.
^ http://www.whonamedit.com/synd.cfm/1202.html

External links[edit]

HARD syndrome; Walker–Warburg syndrome; Chemke syndrome; COD (cerebroocular dysgenesis) at NIH's Office of Rare Diseases

UpToDate Contents

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1. 眼咽頭型、遠位型，および先天性筋ジストロフィー oculopharyngeal distal and congenital muscular dystrophies
2. 新生児における筋緊張低下を引き起こす末梢神経および筋肉の障害に関する概要 overview of peripheral nerve and muscle disorders causing hypotonia in the newborn
3. 水頭症 hydrocephalus
4. 肢帯型筋ジストロフィー limb girdle muscular dystrophy
5. 神経管欠損症の超音波診断 ultrasound diagnosis of neural tube defects

English Journal

Intragenic rearrangements in LARGE and POMGNT1 genes in severe dystroglycanopathies.

Vuillaumier-Barrot S, Bouchet-Seraphin C, Chelbi M, Eude-Caye A, Charluteau E, Besson C, Quentin S, Devisme L, Le Bizec C, Landrieu P, Goldenberg A, Maincent K, Loget P, Boute O, Gilbert-Dussardier B, Encha-Razavi F, Gonzales M, Grandchamp B, Seta N.SourceAPHP, Hopital Bichat-Claude Bernard, Biochimie, Paris, France; INSERM U773 CRB3, Paris, France.
Neuromuscular disorders : NMD.Neuromuscul Disord.2011 Jul 2. [Epub ahead of print]
Dystroglycanopathies are a heterogeneous group of muscular dystrophies with autosomal recessive inheritance characterized by abnormal glycosylation of alpha-dystroglycan. The most severe phenotypes are Walker-Warburg Syndrome (WWS) and muscle-eye-brain disease (MEB) presenting with lissencephaly typ
PMID 21727005

Biochemical correlation of activity of the α-dystroglycan-modifying glycosyltransferase POMGnT1 with mutations in muscle-eye-brain disease.

Voglmeir J, Kaloo S, Laurent N, Meloni MM, Bohlmann L, Wilson IB, Flitsch SL.SourceManchester Interdisciplinary Biocentre, University of Manchester, Manchester M1 7ND, UK.
The Biochemical journal.Biochem J.2011 Jun 1;436(2):447-55.
Congenital muscular dystrophies have a broad spectrum of genotypes and phenotypes and there is a need for a better biochemical understanding of this group of diseases in order to aid diagnosis and treatment. Several mutations resulting in these diseases cause reduced O-mannosyl glycosylation of glyc
PMID 21361872