WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
the 22nd letter of the Roman alphabet (同)v
informal term for information; "give me the gen on your new line of computers"

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1. フォンヒッペル・リンダウ病の分子生物学および病因 molecular biology and pathogenesis of von hippel lindau disease
2. 赤血球増加症患者に対する診断的アプローチ diagnostic approach to the patient with polycythemia
3. 腎細胞癌の疫学、病理、および病因 epidemiology pathology and pathogenesis of renal cell carcinoma
4. 先天性赤血球増多症および真性多血症の分子学的病因 molecular pathogenesis of congenital polycythemic disorders and polycythemia vera
5. 進行腎細胞癌に対する抗血管新生療法および分子標的療法 anti angiogenic and molecularly targeted therapy for advanced renal cell carcinoma

Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review).

Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D.SourceDepartment of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
International journal of oncology.Int J Oncol.2012 Sep;41(3):793-7. doi: 10.3892/ijo.2012.1528. Epub 2012 Jun 25.
Epimutation is defined as abnormal transcriptional repression of active genes and/or abnormal activation of usually repressed genes caused by errors in epigenetic gene repression. Epimutation arises in somatic cells and the germline, and constitutional epimutation
PMID 22735547

Increased expression of the von Hippel-Lindau gene in the implantation site of human tubal pregnancy.

Xu JY, Zhu WJ, Jiang H.SourceInstitute of Reproductive Immunology, College of Life Science and Technology, Jinan University, 601# Huang Pu Da Dao Xi, Guangzhou, 510632, People's Republic of China.
Molecular and cellular biochemistry.Mol Cell Biochem.2012 Sep;368(1-2):173-9. Epub 2012 Jun 20.
The objective of this study was to investigate the expression of the von Hippel-Lindau (VHL) gene in tissues of human fallopian tube and tubal pregnancy. Twenty patients undergoing salpingectomy for tubal pregnancy were recruited into the study group. Tissues of tubal pregnancy were separated into b
PMID 22714833

Coexistence of Sporadic Cerebellar Hemangioblastoma and Pituitary Null Cell Adenoma : Simultaneous Expression of von Hippel-Lindau Gene Product : Case Report

SHIMODA Yoshiteru,OGAWA Yoshikazu,ENDO Hidenori,WATANABE Mika,TOMINAGA Teiji
Neurologia medico-chirurgica = 神経外科 52(8), 591-594, 2012-08-15
… There was no evident family history of von Hippel-Lindau (VHL) disease, and the systemic investigation failed to detect any other tumors or signs of VHL disease. … Additional immunohistochemical investigation using VHL disease gene-related protein in both tumors showed minute granular positive staining in the cytoplasm of stromal cells in the former, and diffuse and strong granular cytoplasmic positive staining in the latter. …
NAID 10030694759

Family history of von Hippel-Lindau disease was uncommon in Chinese patients : suggesting the higher frequency of de novo mutations in VHL gene in these patients

Long-term effect of external beam radiotherapy of optic disc hemangioma in a patient with von hippel-lindau disease

Matsuo Toshihiko,Himei Kengo,Ishii Keita,Ichimura Kouichi,Yanai Hiroyuki,Nose Soichiro,Mimura Tetsushige
Acta Medica Okayama 65(2), 135-141, 2011-04
… An 18-year-old woman with a 2-year history of hypertension and headache was diagnosed with noradrenalin-secreting bilateral adrenal pheochromocytomas with paragangliomas in the background of von Hippel-Lindau disease with family histories and a missense mutation, 712C to T (Arg167Trp) in the VHL gene. …
NAID 120002970770