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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/08/26 20:43:45」(JST)

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Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene.^[1] VCAM-1 functions as a cell adhesion molecule.

Structure

The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. It is alternatively spliced into two known RNA transcripts that encode different isoforms in humans.^[2] The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily.

Function

The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.

Upregulation of VCAM-1 in endothelial cells by cytokines occurs as a result of increased gene transcription (e.g., in response to Tumor necrosis factor-alpha (TNF-α) and Interleukin-1 (IL-1)) and through stabilization of Messenger RNA (mRNA) (e.g., Interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem NF-κB (nuclear factor-kappa B) sites. The sustained expression of VCAM-1 lasts over 24 hours.

Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. VCAM-1 expression has also been observed in other cell types (e.g., smooth muscle cells). It has also been shown to interact with EZR^[3] and Moesin.^[3]

Pharmacology

Certain melanoma cells can use VCAM-1 to adhere to the endothelium, and VCAM-1 may participate in monocyte recruitment to atherosclerotic sites. As a result, VCAM-1 is a potential drug target.

References

^ Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T (1991). "The human VCAM1 gene is assigned to chromosome 1p31-p32". Cytogenet. Cell Genet. 58: 1852. doi:10.1159/000133735.
^ "Entrez Gene: VCAM1 vascular cell adhesion molecule 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7412.
^ ^a ^b Barreiro, Olga; Yanez-Mo Maria, Serrador Juan M, Montoya Maria C, Vicente-Manzanares Miguel, Tejedor Reyes, Furthmayr Heinz, Sanchez-Madrid Francisco (Jun. 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes". J. Cell Biol. (United States) 157 (7): 1233–45. doi:10.1083/jcb.200112126. ISSN 0021-9525. PMC 2173557. PMID 12082081. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173557.

External links

VCAM-1 at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 内皮：プライマー the endothelium a primer
2. リウマチ結節 rheumatoid nodules
3. 糸球体半月体形成の機序 mechanisms of glomerular crescent formation
4. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
5. 全身性エリテマトーデスの疫学および病因 epidemiology and pathogenesis of systemic lupus erythematosus

English Journal

Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis.

Taverna S, Flugy A, Saieva L, Kohn EC, Santoro A, Meraviglia S, De Leo G, Alessandro R.SourceDipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Sezione di Biologia e Genetica, Università di Palermo, Italy.
International journal of cancer. Journal international du cancer.Int J Cancer.2012 May 1;130(9):2033-43. doi: 10.1002/ijc.26217. Epub 2011 Aug 8.
Our study is designed to assess if exosomes released from chronic myelogenous leukemia (CML) cells may modulate angiogenesis. We have isolated and characterized the exosomes generated from LAMA84 CML cells and demonstrated that addition of exosomes to human vascular endothelial cells (HUVEC) induces
PMID 21630268

Involvement of mitogen-activated protein kinases and peroxisome proliferator-activated receptor γ in monosodium urate crystal-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts.

Wang R, Huang W, Liang X.SourceFirst Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
International journal of molecular medicine.Int J Mol Med.2012 May;29(5):877-82. doi: 10.3892/ijmm.2012.925. Epub 2012 Feb 24.
To investigate whether monosodium urate (MSU) crystals could induce the production of VCAM-1 (vascular cell adhesion molecule 1) in human synovial cells and its possible signaling pathways, human synovial cells isolated from synovial tissue explants were stimulat
PMID 22366735

Japanese Journal

Serum endothelial injury markers in hemodialysis patients with arteriovenous fistula stenosis

Saito Osamu,Kotouda Atushi,Saito Takako,Sugase Taro,Akimoto Tetsu,Ando Yasuhiro,Muto Shigeaki,Kusano Eiji
自治医科大学紀要 = Jichi Medical University Journal 35, 1-6, 2013-03-00
… VCAM-1）, and endothelial injury markers（CD146 and thrombomodulin） were compared between 46 patients with AVF stenosis and 76 patientswithout AVF stenosis to determine factors associated with AVF stenosis.Results： The serum adiponectin level was significantly lower in patients with AVF stenosis compared tothose without AVF stenosis. …
NAID 120005295158

Selenium Supplementation Trials for Cancer Prevention and the Subsequent Risk of Type 2 Diabetes Mellitus::Selenium and Vitamin E Cancer Prevention Trial and After

小山洋,,ABDULAH Rizky,山崎千穂,亀尾聡美
日本衛生学雑誌 68(1), 1-10, 2013
… Recently, the association of serum selenium with adipocytokines, such as TNF-α, VCAM-1, leptin, FABP-4, and MCP-1, has been observed. …
NAID 130003369648

Linoleic Acid Attenuates Endothelium-Derived Relaxing Factor Production by Suppressing cAMP-Hydrolyzing Phosphodiesterase Activity

Wei Jiazhang,Takeuchi Kazuhiko,Watanabe Hiroshi
Circulation Journal, 2013
… Background: Linoleic acid (LA) promotes monocyte chemotaxis and cell adhesion molecules such as MCP-1 and VCAM-1, which contribute to atherosclerogenesis. … Hence, the expressions of MCP-1 and VCAM-1 upregulated by LA may be partly attributable to decreased EDRF production. …
NAID 130003361824

Related Pictures

★リンクテーブル★

リンク元	「血管細胞接着分子」「血管内皮細胞接着分子」「細胞接着分子」
拡張検索	「VCAM-1」
関連記事	「VC」「VCA」

「血管細胞接着分子」

Vascular cell adhesion molecule 1
	; PDB rendering based on 1ij9.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1IJ9, 1VCA, 1VSC
Identifiers
Symbols	VCAM1; CD106; INCAM-100
External IDs	OMIM: 192225 MGI: 98926 HomoloGene: 838 ChEMBL: 3735 GeneCards: VCAM1 Gene
Gene Ontology
Molecular function	• integrin binding; • cell adhesion molecule binding; • cell adhesion molecule binding;
Cellular component	• podosome; • extracellular space; • plasma membrane; • microvillus; • external side of plasma membrane; • cell surface; • integral to membrane; • filopodium; • sarcolemma; • apical part of cell; • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex;
Biological process	• response to hypoxia; • acute inflammatory response; • chronic inflammatory response; • cell adhesion; • heterophilic cell-cell adhesion; • leukocyte cell-cell adhesion; • heart development; • aging; • response to nutrient; • response to ionizing radiation; • cytokine-mediated signaling pathway; • membrane to membrane docking; • B cell differentiation; • positive regulation of T cell proliferation; • interspecies interaction between organisms; • regulation of immune response; • leukocyte tethering or rolling; • interferon-gamma-mediated signaling pathway; • chorio-allantoic fusion; • cellular response to glucose stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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