関: galactose-1-phosphate uridyltransferase

WordNet

a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
carbonated drink with fruit syrup and a little phosphoric acid
the 21st letter of the Roman alphabet (同)u
a monosaccharide that contains six carbon atoms per molecule

PrepTutorEJDIC

〈U〉リン酸塩 / 《複数形で》リン酸肥料
uraniumの化学記号
上流の,上流階級にふさわしい / (映画が)児童観覧用の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/28 16:31:02」(JST)

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In enzymology, an UTP-hexose-1-phosphate uridylyltransferase (EC 2.7.7.10) is an enzyme that catalyzes the chemical reaction

UTP + alpha-D-galactose 1-phosphate diphosphate + UDP-galactose

Thus, the two substrates of this enzyme are UTP and alpha-D-galactose 1-phosphate, whereas its two products are diphosphate and UDP-galactose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:alpha-D-hexose-1-phosphate uridylyltransferase. Other names in common use include galactose-1-phosphate uridylyltransferase, galactose 1-phosphate uridylyltransferase, alpha-D-galactose 1-phosphate uridylyltransferase, galactose 1-phosphate uridyltransferase, UDPgalactose pyrophosphorylase, uridine diphosphate galactose pyrophosphorylase, and uridine diphosphogalactose pyrophosphorylase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.

Structural studies

As of late 2007^[update], 3 structures have been solved for this class of enzymes, with PDB accession codes 1GUP, 1GUQ, and 1HXP.

References

ISSELBACHER KJ (1958). "A mammalian uridinediphosphate galactose pyrophosphorylase". J. Biol. Chem. 232 (1): 429–44. PMID 13549431.
KALCKAR HM (1953). "The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides". Biochim. Biophys. Acta. 12 (1-2): 250–64. doi:10.1016/0006-3002(53)90144-9. PMID 13115434.
Lee L, Kimura A, Tochikura T (Tokyo). "Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum". J. Biochem. (4): 923–8. PMID 500588.
Lobelle-Rich PA, Reeves RE (1983). "Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica". Mol. Biochem. Parasitol. 7 (2): 173–82. doi:10.1016/0166-6851(83)90043-9. PMID 6304512.

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English Journal

Gestational dating by metabolic profile at birth: a California cohort study.

Jelliffe-Pawlowski LL1, Norton ME2, Baer RJ3, Santos N4, Rutherford GW5.
American journal of obstetrics and gynecology.Am J Obstet Gynecol.2016 Apr;214(4):511.e1-13. doi: 10.1016/j.ajog.2015.11.029. Epub 2015 Dec 11.
BACKGROUND: Accurate gestational dating is a critical component of obstetric and newborn care. In the absence of early ultrasound, many clinicians rely on less accurate measures, such as last menstrual period or symphysis-fundal height during pregnancy, or Dubowitz scoring or the Ballard (or New Bal
PMID 26688490

Predicting gestational age using neonatal metabolic markers.

Ryckman KK1, Berberich SL2, Dagle JM3.
American journal of obstetrics and gynecology.Am J Obstet Gynecol.2016 Apr;214(4):515.e1-13. doi: 10.1016/j.ajog.2015.11.028. Epub 2015 Dec 2.
BACKGROUND: Accurate gestational age estimation is extremely important for clinical care decisions of the newborn as well as for perinatal health research. Although prenatal ultrasound dating is one of the most accurate methods for estimating gestational age, it is not feasible in all settings. Iden
PMID 26645954

Accurate prediction of gestational age using newborn screening analyte data.

Wilson K1, Hawken S2, Potter BK3, Chakraborty P4, Walker M5, Ducharme R6, Little J7.
American journal of obstetrics and gynecology.Am J Obstet Gynecol.2016 Apr;214(4):513.e1-9. doi: 10.1016/j.ajog.2015.10.017. Epub 2015 Oct 28.
BACKGROUND: Identification of preterm births and accurate estimates of gestational age for newborn infants is vital to guide care. Unfortunately, in developing countries, it can be challenging to obtain estimates of gestational age. Routinely collected newborn infant screening metabolic analytes var
PMID 26519781

「UTPヘキソース-1-リン酸ウリジリルトランスフェラーゼ」

UTP:galactose-1-phosphate uridylyltransferase
Identifiers
EC number	2.7.7.10
CAS number	9016-11-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search
PMC	articles
PubMed	articles
NCBI Protein	search

　　[★]

英: UTP-hexose-1-phosphate uridylyltransferase
関: ガラクトース-1-リン酸ウリジルトランスフェラーゼ、UTP-ヘキソース-1-リン酸ウリジリルトランスフェラーゼ

「UTP-ヘキソース-1-リン酸ウリジリルトランスフェラーゼ」

　　[★]

英: UTP-hexose-1-phosphate uridylyltransferase
関: UTPヘキソース-1-リン酸ウリジリルトランスフェラーゼ

「galactose-1-phosphate uridyltransferase」

　　[★]

ガラクトース-1-リン酸ウリジルトランスフェラーゼ

関: UTP-hexose-1-phosphate uridylyltransferase

「phosphate」

　　[★]

n.

(化合物)リン酸塩、リン酸エステル、ホスフェート、フォスフェート、リン酸

関: inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus

「U」

　　[★]

「UTP」

　　[★]

ウリジン三リン酸 uridine triphosphate

「hexose」

　　[★]

六炭糖、ヘキソース

リンク元	「UTPヘキソース-1-リン酸ウリジリルトランスフェラーゼ」「UTP-ヘキソース-1-リン酸ウリジリルトランスフェラーゼ」「galactose-1-phosphate uridyltransferase」
関連記事	「phosphate」「U」「UTP」「hexose」

匿名

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案内

案内

UTP-hexose-1-phosphate uridylyltransferase