WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
ring slowly; "For whom the bell tolls"
a fee levied for the use of roads or bridges (used for maintenance)
charge a fee for using; "Toll the bridges into New York City"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
found pleasant or attractive; often used as a combining form; "a well-liked teacher"

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
〈鐘が〉(にっくり規則的に繰り返して)鳴る / (ゆっくり規則的に繰り返して)〈鐘〉‘を'鳴らす / 〈鐘が〉…‘を'知らせる / 鐘を鳴らすこと / 鐘の音
(橋・道路などの)『使用[通行]料金』,使用税 / (長距離電話などの)『料金』,サービス料 / 《通例単数形で》(災難などの)被害の程度,犠牲(死傷)負数
=sense organ / 受信装置
(…の)『好み』,趣味《+『for』(『to』)+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/10 23:59:10」(JST)

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[Wiki en表示]

TLR 1 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system.^[1]^[2] TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLR1 has also been designated as CD281 (cluster of differentiation 281).

TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.^[3]

TLR1 recognises peptidoglycan and (triacyl) lipoproteins in concert with TLR2 (as a heterodimer).^[4]^[5] Toll-like receptors, including TLR-1, found on the epithelial cell layer that lines the small and large intestine are important players the management of the gut microbiota and detection of pathogens.^[6] It is also found on the surface of macrophages and neutrophils.

Interactions

TLR 1 has been shown to interact with TLR 2.^[7]

References

^ Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (January 1998). "A family of human receptors structurally related to Drosophila Toll". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 588–93. doi:10.1073/pnas.95.2.588. PMC 18464. PMID 9435236.
^ Lien E, Ingalls RR (January 2002). "Toll-like receptors". Crit. Care Med. 30 (1 Suppl): S1–11. doi:10.1097/00003246-200201001-00001. PMID 11782555.
^ "SRF serum response factor". Entrez Gene. National Center for Biotechnology Information, National Institutes of Health.
^ Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH, Ulmer AJ (March 2008). "Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling". J. Leukoc. Biol. 83 (3): 692–701. doi:10.1189/jlb.0807586. PMID 18056480.
^ Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO (September 2007). "Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide". Cell 130 (6): 1071–82. doi:10.1016/j.cell.2007.09.008. PMID 17889651.
^ de Kivit S, Tobin MC, Forsyth CB, Keshavarzian A, Landay AL (2014). "Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics". Frontiers in Immunology 5: 60. doi:10.3389/fimmu.2014.00060. PMC 3927311. PMID 24600450.
^ Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S (Jul 2002). "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins". J. Immunol. 169 (1): 10–4. doi:10.4049/jimmunol.169.1.10. PMID 12077222.

External links

Toll-Like Receptor 1 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine ([3]), which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy
2. 結核の免疫学 immunology of tuberculosis
3. ライム病の免疫病因 immunopathogenesis of lyme disease
4. 虚血後（虚血性）の急性尿細管壊死の発症および病因 pathogenesis and etiology of postischemic ischemic acute tubular necrosis
5. 高齢者における免疫機能 immune function in older adults

English Journal

TLR1 polymorphism rs4833095 as a risk factor for IgA nephropathy in a Chinese Han population: A case-control study.

Gao J1, Wei L1, Wei J2, Yao G1, Wang L1, Wang M3, Liu X3, Dai C3, Jin T4, Dai Z3, Fu R1.
Oncotarget.Oncotarget.2016 Oct 28. doi: 10.18632/oncotarget.12965. [Epub ahead of print]
Toll-like receptors (TLRs) are a family of transmembrane receptors, and play a vital role in recognizing invading pathogens and activating innate immunity. Previous studies indicated that TLR1 single nucleotide polymorphisms (SNPs) might be associated with the risk of IgA nephropathy (IgAN). This st
PMID 27806314

Comparative genomic evidence for duplication of TLR1 subfamily and miiuy croaker TLR1 perceives LPS stimulation via MyD88 and TIRAP.

Xu T1, Wang Y2, Li J2, Shu C2, Han J2, Chu Q2.
Fish & shellfish immunology.Fish Shellfish Immunol.2016 Sep;56:336-48. doi: 10.1016/j.fsi.2016.07.024. Epub 2016 Jul 16.
Being indispensable pattern recognition receptors in innate immune responses in host protection, Toll-like receptors (TLRs) play an important role in pathogen recognition. Fish TLRs exhibit high variety and distinct features, although little is known about their function on ligand recognition and si
PMID 27431585

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies.

Uchino K1, Mizuno S2, Mizutani M3, Horio T4, Hanamura I5, Espinoza JL6, Matsuo K7, Onizuka M8, Kashiwase K9, Morishima Y10, Fukuda T11, Kodera Y12, Doki N13, Miyamura K14, Mori TM15, Takami A16; Japan Marrow Donor Program.
Transplant immunology.Transpl Immunol.2016 Sep;38:60-6. doi: 10.1016/j.trim.2016.06.002. Epub 2016 Jun 28.
Toll-like receptor 1 (TLR1) genetic variant (rs5743551, -7202A>G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched
PMID 27369862

Japanese Journal

Toll-like receptorによるリガンド認識機構

臨床免疫・アレルギー科 = Clinical immunology & allergology 65(3), 262-270, 2016-03
NAID 40020765783

正常マウス皮膚にTLR7アゴニストを外用することによる新規ループス腎炎モデルマウスの開発 (特集全身性免疫疾患の機序の解明)

臨床免疫・アレルギー科 = Clinical immunology & allergology 65(2), 119-125, 2016-02
NAID 40020741922

Recruitment of distinct immune cell populations to the lung after intratracheal TLR4 signaling activation by two different stimulations

Acta medica Nagasakiensia 60(2), 77-84, 2016-01
NAID 120005702465

Related Pictures

★リンクテーブル★

リンク元	「Toll様受容体1」「Toll様レセプター1」「TLR1」
拡張検索	「Toll-like receptor 10」
関連記事	「like」「toll」

「Toll様受容体1」

Toll-like receptor 1
	PDB rendering based on 1fyv.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1FYV, 2Z7X
Identifiers
Symbols	TLR1 ; CD281; TIL; TIL. LPRS5; rsc786
External IDs	OMIM: 601194 MGI: 1341295 HomoloGene: 20694 GeneCards: TLR1 Gene
Gene ontology
Molecular function	• receptor activity; • transmembrane signaling receptor activity; • protein heterodimerization activity;
Cellular component	• plasma membrane; • integral component of plasma membrane; • membrane; • phagocytic vesicle membrane; • Toll-like receptor 1-Toll-like receptor 2 protein complex;
Biological process	• MyD88-dependent toll-like receptor signaling pathway; • inflammatory response; • immune response; • signal transduction; • toll-like receptor 1 signaling pathway; • macrophage activation; • detection of triacyl bacterial lipopeptide; • positive regulation of tumor necrosis factor biosynthetic process; • innate immune response; • positive regulation of interleukin-6 biosynthetic process; • regulation of cytokine secretion; • cellular response to triacyl bacterial lipopeptide;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;