関: TLR10

WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
ring slowly; "For whom the bell tolls"
a fee levied for the use of roads or bridges (used for maintenance)
charge a fee for using; "Toll the bridges into New York City"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
found pleasant or attractive; often used as a combining form; "a well-liked teacher"

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
〈鐘が〉(にっくり規則的に繰り返して)鳴る / (ゆっくり規則的に繰り返して)〈鐘〉‘を'鳴らす / 〈鐘が〉…‘を'知らせる / 鐘を鳴らすこと / 鐘の音
(橋・道路などの)『使用[通行]料金』,使用税 / (長距離電話などの)『料金』,サービス料 / 《通例単数形で》(災難などの)被害の程度,犠牲(死傷)負数
=sense organ / 受信装置
(…の)『好み』,趣味《+『for』(『to』)+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/09 00:18:42」(JST)

wiki en

Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene.^[1] TLR10 has also been designated as CD290 (cluster of differentiation 290).

Function

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Its exact function is not known. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[2]

References

^ Chuang T, Ulevitch RJ (Mar 2001). "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells". Biochim Biophys Acta 1518 (1-2): 157–61. doi:10.1016/s0167-4781(00)00289-x. PMID 11267672.
^ "Entrez Gene: TLR10 toll-like receptor 10".

External links

Toll-Like Receptor 10 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on chromosome 4 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy

English Journal

Association of toll-like receptor 10 polymorphisms with autoimmune thyroid disease in korean children.

Cho WK1, Jang JP, Choi EJ, Jeon YJ, Jung IA, Kim SH, Jung MH, Kim TG, Suh BK.
Thyroid : official journal of the American Thyroid Association.Thyroid.2015 Feb;25(2):250-5. doi: 10.1089/thy.2014.0135. Epub 2014 Nov 12.
BACKGROUND: The Toll-like receptors (TLRs) are germline-encoded receptors that play an essential role in initiating the immune response against pathogens. In this study, we assess the association of TLR polymorphism with autoimmune thyroid disease (AITD) in Korean children.METHODS: We investigated t
PMID 25295614

The host response: Toll-like receptor expression in periprosthetic tissues as a biomarker for deep joint infection.

Cipriano C1, Maiti A1, Hale G1, Jiranek W1.
The Journal of bone and joint surgery. American volume.J Bone Joint Surg Am.2014 Oct 15;96(20):1692-8. doi: 10.2106/JBJS.M.01295.
BACKGROUND: Toll-like receptors (TLRs) 1 and 6 are consistent molecular indicators of the host inflammatory response against bacterial infection. Our aims were to determine whether TLR elevation could be detected in infected periprosthetic tissues and to assess the utility of these biomarkers as tes
PMID 25320195

1,25-Dihydroxyvitamin D3 up-regulates TLR10 while down-regulating TLR2, 4, and 5 in human monocyte THP-1.

Verma R1, Jung JH1, Kim JY2.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2014 May;141:1-6. doi: 10.1016/j.jsbmb.2013.12.012. Epub 2013 Dec 25.
In humans, there are ten Toll-like receptors (TLRs), among which TLR10 is the only orphan receptor whose function is unknown. In this study, we examined the effects of IFN-γ, LPS and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on TLR10 expression of human monocyte THP-1 and compared them with those of o
PMID 24373795

Japanese Journal

数種の乳酸菌およびトール様受容体 2 リガンドで刺激したマウスマクロファージ様株化細胞 J774.1による IL-12産生をLactobacillus crispatus KT-11株は促す

飛田啓輔,大谷元
ミルクサイエンス 64(1), 1-6, 2015
… J774.1細胞培養上清中の IL-12濃度は，10 μg/mL以上の KT-11の添加によって有意に高くなった。 …
NAID 130005065639

ロイシンリッチリピート蛋白ファミリー

國島伸治
日本血栓止血学会誌 26(1), 10
要約：ロイシンリッチリピート蛋白ファミリーに属するGPIb/IX/V はGPIIb/IIIa に続いて血小板に数多く発現する巨核球/血小板特異的受容体である．GPIb/IX/V はvon Willebrand 因子（vWF）受容体として一次止血に働くが，血栓止血以外にも幅広い生理的および病理的現象に関わることが明らかになっている．先天性GPIb/IX/V 欠損は重篤な出血症状と巨大血小板性血小板減 …
NAID 130004847366

1. Bacterial contamination hypothesis : 細菌性エンドトキシンとToll-like receptor 4(TLR4)が司る子宮内膜症の増殖・進展に関する新たな病態生理(シンポジウム3(生殖・女性ヘルスケア) 子宮内膜症の病因・病態解明と治療戦略,第66回日本産科婦人科学会・学術講演会)

カーンカレク
日本産科婦人科學會雜誌 66(12), 2885-2894, 2014-12-01
… As a component of innate immune system, information regarding the role of macrophages and Toll-like receptors (TLRs) in endometriosis is lacking. … Menstrual blood was contaminated with E.coli and colony formation of E.coli was significantly higher in women with endometriosis (10^5-10^7CFU/mL) than in control women (<10^2CFU/mL). …
NAID 110009895996

「Toll様受容体10」

Toll-like receptor 10
	; PDB rendering based on 2j67.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2J67
Identifiers
Symbols	TLR10 ; CD290
External IDs	OMIM: 606270 HomoloGene: 12809 GeneCards: TLR10 Gene
Gene ontology
Molecular function	• transmembrane signaling receptor activity;
Cellular component	• plasma membrane; • membrane; • integral to membrane;
Biological process	• toll-like receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • inflammatory response; • immune response; • toll-like receptor 5 signaling pathway; • toll-like receptor 10 signaling pathway; • innate immune response; • regulation of cytokine secretion; • positive regulation of inflammatory response;
	Sources: Amigo / QuickGO
Orthologs
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