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TLR 1 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system.^[1]^[2] TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLR1 has also been designated as CD281 (cluster of differentiation 281).

TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.^[3]

TLR1 recognises peptidoglycan and (triacyl) lipoproteins in concert with TLR2 (as a heterodimer).^[4]^[5] It is found on the surface of macrophages and neutrophils.

Interactions

TLR 1 has been shown to interact with TLR 2.^[6]

References

^ Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (January 1998). "A family of human receptors structurally related to Drosophila Toll". Proc. Natl. Acad. Sci. U.S.A. 95 (2): 588–93. doi:10.1073/pnas.95.2.588. PMC 18464. PMID 9435236.
^ Lien E, Ingalls RR (January 2002). "Toll-like receptors". Crit. Care Med. 30 (1 Suppl): S1–11. doi:10.1097/00003246-200201001-00001. PMID 11782555.
^ "SRF serum response factor". Entrez Gene. National Center for Biotechnology Information, National Institutes of Health.
^ Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J et al. (March 2008). "Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling". J. Leukoc. Biol. 83 (3): 692–701. doi:10.1189/jlb.0807586. PMID 18056480.
^ Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG et al. (September 2007). "Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide". Cell 130 (6): 1071–82. doi:10.1016/j.cell.2007.09.008. PMID 17889651.
^ Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z et al. (Jul 2002). "Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins". J. Immunol. 169 (1): 10–4. doi:10.4049/jimmunol.169.1.10. PMID 12077222.

External links

Toll-Like Receptor 1 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine ([3]), which is in the public domain.

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English Journal

Up-regulated of miR-8159-5p and miR-217-5p by LPS stimulation negatively co-regulate TLR1 in miiuy croaker.

Chu Q1, Sun Y1, Bi D1, Cui J1, Xu T2.
Developmental and comparative immunology.Dev Comp Immunol.2017 Feb;67:117-125. doi: 10.1016/j.dci.2016.11.004. Epub 2016 Nov 7.
Toll-like receptors (TLRs) are a group of pattern-recognition receptors which play vital roles in ligand recognition and activation of the innate immune response. As an important member of TLRs family, TLR1 is mainly responsible for PAMPs from bacteria and play a pivotal role in sensing microbial pr
PMID 27832948

Molecular characterization and immunological response analysis of toll-like receptors from the blunt snout bream (Megalobrama amblycephala).

Lai RF1, Jakovlić I2, Liu H3, Zhan FB4, Wei J5, Wang WM6.
Developmental and comparative immunology.Dev Comp Immunol.2017 Feb;67:471-475. doi: 10.1016/j.dci.2016.09.005. Epub 2016 Sep 14.
The innate immunity serves as the primary line of defense against pathogen invasion. Toll-like receptors (TLRs) play a pivotal role in the innate immunity by sensing specific pathogen-associated molecular patterns and activating immune responses. In this study, 14 TLRs (TLR1, 2, 3, 4, 5, 7, 8a, 8b,
PMID 27639315

Identification of novel signature genes attesting arsenic-induced immune alterations in adult zebrafish (Danio rerio).

Ray A1, Bhaduri A2, Srivastava N3, Mazumder S4.
Journal of hazardous materials.J Hazard Mater.2017 Jan 5;321:121-131. doi: 10.1016/j.jhazmat.2016.09.001. Epub 2016 Sep 3.
Arsenic poisoning is a serious global issue. Apart from causing developmental and systemic toxicity, arsenic has recently been reported for its ability to hinder immune responses. The present study is designed to identify the global expression profile associated with arsenic-induced immune alteratio
PMID 27614325

Japanese Journal

Functional analysis of pattern recognition receptors in miniature dachshunds with inflammatory colorectal polyps

Journal of Veterinary Medical Science 77(4), 439-447, 2015
NAID 130005067028

Functional analysis of pattern recognition receptors in miniature dachshunds with inflammatory colorectal polyps

Journal of Veterinary Medical Science advpub(0), 2014
NAID 130004781057

Toll-Like Receptors Required for <i>Dermatophagoides farinae</i> to Activate NF-κB

Biological and Pharmaceutical Bulletin 37(1), 74-80, 2014
NAID 130003382102

「Toll様受容体1」

Toll-like receptor 1
	; PDB rendering based on 1fyv.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1FYV, 2Z7X
Identifiers
Symbols	TLR1 ; CD281; TIL; TIL. LPRS5; rsc786
External IDs	OMIM: 601194 MGI: 1341295 HomoloGene: 20694 IUPHAR: 1751 GeneCards: TLR1 Gene
Gene ontology
Molecular function	• receptor activity; • transmembrane signaling receptor activity; • protein heterodimerization activity;
Cellular component	• plasma membrane; • integral component of plasma membrane; • membrane; • phagocytic vesicle membrane; • Toll-like receptor 1-Toll-like receptor 2 protein complex;
Biological process	• MyD88-dependent toll-like receptor signaling pathway; • inflammatory response; • immune response; • signal transduction; • toll-like receptor 1 signaling pathway; • macrophage activation; • detection of triacyl bacterial lipopeptide; • positive regulation of tumor necrosis factor biosynthetic process; • innate immune response; • positive regulation of interleukin-6 biosynthetic process; • regulation of cytokine secretion; • cellular response to triacyl bacterial lipopeptide;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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