同: T cell factor-1＆T cell development

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HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene.^[1]^[2]

The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.^[3]

Interactions[edit]

HNF1A has been shown to interact with PCAF,^[7] Src,^[7] RAC3,^[7] EP300,^[8] CREB-binding protein^[7] and PCBD1.^[9]^[10]

References[edit]

^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.
^ Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (April 1995). "A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q". Nat. Genet. 9 (4): 418–23. doi:10.1038/ng0495-418. PMID 7795649.
^ Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (October 1987). "Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters". Science 238 (4827): 688–92. doi:10.1126/science.3499668. PMID 3499668.
^ Hines RN, Luo Z, Cresteil T, Ding X, Prough RA, Fitzpatrick JL, Ripp SL, Falkner KC, Ge NL, Levine A, Elferink CJ (May 2001). "Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors". Drug Metab. Dispos. 29 (5): 623–33. PMID 11302926.
^ Rufibach LE, Duncan SA, Battle M, Deeb SS (July 2006). "Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter". J. Lipid Res. 47 (7): 1463–77. doi:10.1194/jlr.M600082-JLR200. PMID 16603721.
^ ^a ^b Bulla GA, Kraus DM (December 2004). "Dissociation of the hepatic phenotype from HNF4 and HNF1alpha expression". Biosci. Rep. 24 (6): 595–608. doi:10.1007/s10540-005-2794-8. PMID 16158197.
^ ^a ^b ^c ^d Soutoglou, E; Papafotiou G, Katrakili N, Talianidis I (April 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. (UNITED STATES) 275 (17): 12515–20. doi:10.1074/jbc.275.17.12515. ISSN 0021-9258. PMID 10777539. Cite uses deprecated parameters (help)
^ Ban, Nobuhiro; Yamada Yuichiro, Someya Yoshimichi, Miyawaki Kazumasa, Ihara Yu, Hosokawa Masaya, Toyokuni Shinya, Tsuda Kinsuke, Seino Yutaka (May 2002). "Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter". Diabetes (United States) 51 (5): 1409–18. doi:10.2337/diabetes.51.5.1409. ISSN 0012-1797. PMID 11978637. Cite uses deprecated parameters (help)
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. Cite uses deprecated parameters (help)
^ Sourdive, D J; Transy C, Garbay S, Yaniv M (April 1997). "The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity". Nucleic Acids Res. (ENGLAND) 25 (8): 1476–84. doi:10.1093/nar/25.8.1476. ISSN 0305-1048. PMC 146627. PMID 9092652. Cite uses deprecated parameters (help)

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HNF1 homeobox A
	; PDB rendering based on 1ic8.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1IC8, 2GYP
Identifiers
Symbols	HNF1A; HNF-1A; HNF1; IDDM20; LFB1; MODY3; TCF-1; TCF1
External IDs	OMIM: 142410 MGI: 98504 HomoloGene: 459 GeneCards: HNF1A Gene
Gene Ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; • DNA binding; • double-stranded DNA binding; • sequence-specific DNA binding transcription factor activity; • protein binding; • transcription factor binding; • protein homodimerization activity; • sequence-specific DNA binding; • transcription regulatory region DNA binding; • protein heterodimerization activity; • protein dimerization activity;
Cellular component	• photoreceptor outer segment; • nucleus; • transcription factor complex; • cytoplasm; • protein complex; • pronucleus;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • blastocyst development; • liver development; • placenta development; • chromatin remodeling; • regulation of transcription from RNA polymerase II promoter; • fatty acid biosynthetic process; • bile acid biosynthetic process; • heme biosynthetic process; • response to oxidative stress; • protein localization; • cholesterol metabolic process; • response to glucose stimulus; • bile acid and bile salt transport; • fatty acid transport; • insulin secretion; • regulation of Wnt receptor signaling pathway; • embryonic limb morphogenesis; • endocrine pancreas development; • regulation of pronephros size; • renal glucose absorption; • glucose homeostasis; • reverse cholesterol transport; • bone resorption; • positive regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter; • glucose import; • paraxial mesoderm formation; • reproductive structure development; • regulation of insulin secretion; • positive regulation of transcription initiation from RNA polymerase II promoter; • SMAD protein signal transduction;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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　　[★]

「TCF」

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T細胞因子 T-cell factor
全大腸内視鏡検査とかtotal colon scopyを指しているらしい

[pmid1535333-1] Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333.

[pmid7795649-2] Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (April 1995). "A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q". Nat. Genet. 9 (4): 418–23. doi:10.1038/ng0495-418. PMID 7795649.

[pmid3499668-3] Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (October 1987). "Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters". Science 238 (4827): 688–92. doi:10.1126/science.3499668. PMID 3499668.

[pmid11302926-4] Hines RN, Luo Z, Cresteil T, Ding X, Prough RA, Fitzpatrick JL, Ripp SL, Falkner KC, Ge NL, Levine A, Elferink CJ (May 2001). "Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors". Drug Metab. Dispos. 29 (5): 623–33. PMID 11302926.

[pmid16603721-5] Rufibach LE, Duncan SA, Battle M, Deeb SS (July 2006). "Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter". J. Lipid Res. 47 (7): 1463–77. doi:10.1194/jlr.M600082-JLR200. PMID 16603721.

[pmid16158197-6] Bulla GA, Kraus DM (December 2004). "Dissociation of the hepatic phenotype from HNF4 and HNF1alpha expression". Biosci. Rep. 24 (6): 595–608. doi:10.1007/s10540-005-2794-8. PMID 16158197.

[pmid10777539-7] Soutoglou, E; Papafotiou G, Katrakili N, Talianidis I (April 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. (UNITED STATES) 275 (17): 12515–20. doi:10.1074/jbc.275.17.12515. ISSN 0021-9258. PMID 10777539. Cite uses deprecated parameters (help)

[pmid11978637-8] Ban, Nobuhiro; Yamada Yuichiro, Someya Yoshimichi, Miyawaki Kazumasa, Ihara Yu, Hosokawa Masaya, Toyokuni Shinya, Tsuda Kinsuke, Seino Yutaka (May 2002). "Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter". Diabetes (United States) 51 (5): 1409–18. doi:10.2337/diabetes.51.5.1409. ISSN 0012-1797. PMID 11978637. Cite uses deprecated parameters (help)

[pmid17353931-9] Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. Cite uses deprecated parameters (help)

[pmid9092652-10] Sourdive, D J; Transy C, Garbay S, Yaniv M (April 1997). "The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity". Nucleic Acids Res. (ENGLAND) 25 (8): 1476–84. doi:10.1093/nar/25.8.1476. ISSN 0305-1048. PMC 146627. PMID 9092652. Cite uses deprecated parameters (help)

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