WordNet
- aerobic bacteria (some of which produce the antibiotic streptomycin)
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/12/06 10:47:30」(JST)
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Streptomyces roseosporus |
Scientific classification |
Kingdom: |
Bacteria |
Phylum: |
Actinobacteria |
Class: |
Actinobacteria |
Order: |
Actinomycetales |
Family: |
Streptomycetaceae |
Genus: |
Streptomyces |
Species: |
S. roseosporus |
Binomial name |
Streptomyces roseosporus
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Streptomyces roseosporus is a species of actinobacteria. It produces the novel antibiotic daptomycin (US trade name: Cubicin).
References
UpToDate Contents
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English Journal
- Transcriptional Regulation of the Daptomycin Gene Cluster in Streptomyces roseosporus by an Autoregulator, AtrA.
- Mao XM1, Luo S2, Zhou RC2, Wang F2, Yu P2, Sun N2, Chen XX3, Tang Y4, Li YQ5.
- The Journal of biological chemistry.J Biol Chem.2015 Mar 20;290(12):7992-8001. doi: 10.1074/jbc.M114.608273. Epub 2015 Feb 3.
- Daptomycin is a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus. To reveal the transcriptional regulatory mechanism of daptomycin biosynthesis, we used the biotinylated dptE promoter (dptEp) as a probe to affinity isolate the dptEp-interactive protein AtrA, a TetR family transcrip
- PMID 25648897
- Genome engineering and direct cloning of antibiotic gene clusters via phage ϕBT1 integrase-mediated site-specific recombination in Streptomyces.
- Du D1, Wang L2, Tian Y3, Liu H4, Tan H3, Niu G3.
- Scientific reports.Sci Rep.2015 Mar 4;5:8740. doi: 10.1038/srep08740.
- Several strategies have been used to clone large DNA fragments directly from bacterial genome. Most of these approaches are based on different site-specific recombination systems consisting of a specialized recombinase and its target sites. In this study, a novel strategy based on phage ϕBT1 integr
- PMID 25737113
- Proteome-wide lysine acetylation profiling of the human pathogen Mycobacterium tuberculosis.
- Xie L1, Wang X2, Zeng J1, Zhou M1, Duan X1, Li Q1, Zhang Z1, Luo H1, Pang L1, Li W1, Liao G1, Yu X2, Li Y2, Huang H3, Xie J4.
- The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2015 Feb;59:193-202. doi: 10.1016/j.biocel.2014.11.010. Epub 2014 Nov 29.
- N(ɛ)-Acetylation of lysine residues represents a pivotal post-translational modification used by both eukaryotes and prokaryotes to modulate diverse biological processes. Mycobacterium tuberculosis is the causative agent of tuberculosis, one of the most formidable public health threats. Many aspect
- PMID 25456444
Japanese Journal
- P-48 転位反応を活用したアゲラスタチンAとコナゲニンの合成研究(ポスター発表の部)
- 山岡 具倫,市川 善康,松川 洋平,磯部 稔
- 天然有機化合物討論会講演要旨集 (47), 583-588, 2005-09-15
- … Conagenin (1) is a unique biologically important secondary metabolite isolated from the culture broths of Streptomyces roseosporus by Ishizuka and co-workers. …
- NAID 110006682610
Related Links
- Daptomycin, a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus, displays potent activity against a variety of gram-positive pathogens. There is a demand for generating high-producing strains for ...
- 1. Microbiology. 2005 May;151(Pt 5):1507-23. Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry. Miao V, Coëffet-Legal MF, Brian P, Brost R ...
★リンクテーブル★
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- 英
- daptomycin, DAP, DAPT
- 商
- キュビシン
- 関
- 抗菌薬、抗MRSA薬。主としてグラム陽性菌に作用するもの。環状リポペプチド系抗菌薬
[show details]
Streptomyces roseosporusの発酵産物から得られた抗菌薬/抗生物質。
- 13個のアミノ酸残基からなり、そのうち10アミノ酸残基が環を形成し、N末端のトリプトファンにデカノイル基が結合している。
- メチシリン耐性黄色ブドウ球菌(MRSA)を含む、Staphylococcus属、Enterococcus属、Streptococcus属といった、臨床上重要なグラム陽性菌に対し殺菌作用を示す。
- 作用機序:細胞の構成要素であるペプチドグリカンの合成阻害、細胞透過性の破壊、リポタイコ酸合成阻害、細胞膜電位の破壊など
- 耐性を取られにくい
- 生体利用率は悪く点滴静注のみ
- 代謝:80%が肝臓で代謝される。
- 生体移行性:軟部組織への移行性は良好。肺胞内では肺サーファクタントと結合して抗菌活性が低下する。
- 濃度依存性
- postantibiotic effectを有する
- 全てのグラム陽性球菌に有効。
- グラム陰性桿菌には活性がない。
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redirect ストレプトマイセス属
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ストレプトマイセス属