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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/15 14:18:25」(JST)
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- 1. 薬物療法の最新情報 whats new in drug therapy
English Journal
- Simultaneous determination of aflatoxin M1, ochratoxin A, zearalenone and α-zearalenol in milk by UHPLC-MS/MS.
- Huang LC, Zheng N, Zheng BQ, Wen F, Cheng JB, Han RW, Xu XM, Li SL, Wang JQ.Author information Ministry of Agriculture Laboratory of Quality & Safety Risk Assessment for Dairy Products (Beijing), Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, PR China; Ministry of Agriculture - Milk and Dairy Product Inspection Center (Beijing), Beijing 100193, PR China.AbstractIn this study, a sensitive and rapid method has been developed for the simultaneous determination of aflatoxin M1, ochratoxin A, zearalenone and α-zearalenol in milk by ultra high performance liquid chromatography combined with electrospray ionisation triple quadrupole tandem mass spectrometry (UHPLC-ESI-MS/MS). The milk samples were purified using Oasis HLB cartridge. The matrix effects were evaluated by determining the signal suppression-enhancement (SSE) and corrected by external matrix-matched calibration. The limits of quantity (LOQ) of the mycotoxins were in the range of 0.003-0.015μgkg(-1). The high correlation coefficients (R(2)⩾0.996) were obtained in the range of 0.01-1.00μgkg(-1) of the mycotoxins, along with good recovery (87.0-109%), repeatability (3.4-9.9%) and intra-laboratory reproducibility (4.0-9.9%) at the concentrations of 0.025, 0.1 and 0.5μgkg(-1). The detected rates of the mycotoxins were from 16.7% to 96.7% in raw milk, liquid milk and milk powder samples collected from the dairy farms and supermarkets in Beijing. The method proposed is suitable for the simultaneous determination of aflatoxin M1, ochratoxin A, zearalenone, and α-zearalenol, and could be performed for analysing the mycotoxins in milk.
- Food chemistry.Food Chem.2014 Mar 1;146:242-9. doi: 10.1016/j.foodchem.2013.09.047. Epub 2013 Sep 18.
- In this study, a sensitive and rapid method has been developed for the simultaneous determination of aflatoxin M1, ochratoxin A, zearalenone and α-zearalenol in milk by ultra high performance liquid chromatography combined with electrospray ionisation triple quadrupole tandem mass spectrometry (UHP
- PMID 24176338
- Quantification of the density of cooperative neighboring synapses required to evoke endocannabinoid signaling.
- Pachoud B1, Sharma P1, Bergerot A1, Knöpfel T2, Marcaggi P3.Author information 1Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.2Division of Brain Sciences, Imperial College, London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.3Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK; IBENS, INSERM U1024 CNRS UMR8197, Ecole Normale Supérieure 46, rue d'Ulm, 75005 Paris, France. Electronic address: paikan.marcaggi@ens.fr.AbstractThe spatial pattern of synapse activation may impact on synaptic plasticity. This applies to the synaptically-evoked endocannabinoid-mediated short-term depression at the parallel fiber (PF) to Purkinje cell synapse, the occurrence of which requires close proximity between the activated synapses. Here, we determine quantitatively this required proximity, helped by the geometrical organization of the cerebellar molecular layer. Transgenic mice expressing a calcium indicator selectively in granule cells enabled the imaging of action potential-evoked presynaptic calcium rise in isolated, single PFs. This measurement was used to derive the number of PFs activated within a beam of PFs stimulated in the molecular layer, from which the density of activated PFs (input density) was calculated. This density was on average 2.8μm(-2) in sagittal slices and twice more in transverse slices. The synaptically-evoked endocannabinoid-mediated suppression of excitation (SSE) evoked by ten stimuli at 200Hz was determined from the monitoring of either postsynaptic responses or presynaptic calcium rise. The SSE was significantly larger when recorded in transverse slices, where the input density is larger. The exponential description of the SSE plotted as a function of the input density suggests that the SSE is half reduced when the input density decreases from 6 to 2μm(-2). We conclude that, although all PFs are truncated in an acute sagittal slice, half of them remain respondent to stimulation, and activated synapses need to be closer than 1.5μm to synergize in endocannabinoid signaling.
- Neuroscience.Neuroscience.2014 Jan 3;256:412-25. doi: 10.1016/j.neuroscience.2013.10.041. Epub 2013 Oct 30.
- The spatial pattern of synapse activation may impact on synaptic plasticity. This applies to the synaptically-evoked endocannabinoid-mediated short-term depression at the parallel fiber (PF) to Purkinje cell synapse, the occurrence of which requires close proximity between the activated synapses. He
- PMID 24183961
- Radium ra 223 dichloride injection: u.s. Food and drug administration drug approval summary.
- Kluetz PG, Pierce W, Maher VE, Zhang H, Tang S, Song P, Liu Q, Haber MT, Leutzinger EE, Al-Hakim A, Chen W, Palmby T, Alebachew E, Sridhara R, Ibrahim A, Justice R, Pazdur R.Author information Authors' Affiliations: Office of Hematology and Oncology Products, Office of Biostatistics, Office of Clinical Pharmacology, and Office of Pharmaceutical Science, Office of New Drug Quality Assessment, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland.AbstractOn May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium Ra 223 dichloride (Ra-223; Xofigo injection; Bayer HealthCare Pharmaceuticals Inc.) for the treatment of patients with castration-resistant prostate cancer (CRPC), symptomatic bone metastases, and no known visceral metastatic disease. The FDA review was based on clinical trial BC1-06, which randomly allocated patients (2:1) to either Ra-223 plus best standard of care (BSoC) or placebo plus BSoC. The primary endpoint was overall survival (OS) with a key secondary endpoint of time to first symptomatic skeletal event (SSE). A statistically significant improvement in OS was demonstrated [HR, 0.70; 95% confidence interval, 0.55-0.88, P = 0.0019]. At the prespecified interim analysis, the median OS durations were 14.0 and 11.2 months in the Ra-223 and placebo arms, respectively. The improvement in OS was supported by a delay in time to first SSE favoring the Ra-223 arm. The most common (>10%) adverse reactions in patients receiving Ra-223 were nausea, diarrhea, vomiting, and peripheral edema. The most common (>10%) hematologic laboratory abnormalities were anemia, lymphocytopenia, leukopenia, thrombocytopenia, and neutropenia. Ra-223 is the first α-emitting radiotherapeutic and the first radiopharmaceutical to demonstrate an OS advantage in metastatic prostate cancer. Clin Cancer Res; 20(1); 9-14. ©2013 AACR.
- Clinical cancer research : an official journal of the American Association for Cancer Research.Clin Cancer Res.2014 Jan 1;20(1):9-14. doi: 10.1158/1078-0432.CCR-13-2665. Epub 2013 Nov 4.
- On May 15, 2013, the U.S. Food and Drug Administration (FDA) approved radium Ra 223 dichloride (Ra-223; Xofigo injection; Bayer HealthCare Pharmaceuticals Inc.) for the treatment of patients with castration-resistant prostate cancer (CRPC), symptomatic bone metastases, and no known visceral metastat
- PMID 24190979
Japanese Journal
- 2012年に発生した北海道北部中川町付近の群発地震活動
- 一柳 昌義,高橋 浩晃,山口 照寛,東 龍介,山田 卓司,大園 真子,眞城 亮成,笠原 稔,谷岡 勇市郎
- 北海道大学地球物理学研究報告 78, 37-51, 2015-03-19
- … A slow slip event (SSE) with Mw 5.4 coincidentally detected by GNSS crustal deformation data during the swarm. … This swarm was situated at the southeastern end of the fault of SSE. … This fact suggested that seismic swarm might triggered SSE or was induced by SSE. …
- NAID 120005572453
- 機能局在型ニューラルネットワークの訓練に適した評価関数の検討
- 笹川 隆史
- 電気学会論文誌. C 135(4), 436-443, 2015
- … Based on the analysis result, this paper proposes an evaluation function combining the ordinary sum of squared errors (SSE) and the variance of module SSE, and applies it to a BP training. …
- NAID 130005062212
- Quantum-dot blue light emitting diodes utilizing organic/inorganic hybrid structures
- Wu Feifei,Hu Lian,Zhang Bingpo,Li Ruifeng,Wu Huizhen
- Jpn. J. Appl. Phys. 54(2S), 02BC03, 2014-12-22
- … It is further found that the intensity ratio between surface-state emission (SSE) and band-edge emission (BEE) (R<inf>S/B</inf>) of the two devices shows significant difference at high bias voltages. … The SSE becomes more prominent at higher bias voltage in the QDLEDs due to the imbalance injection of holes and electrons. …
- NAID 150000110076
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