WordNet

the 18th letter of the Roman alphabet (同)r
ancient Egyptian sun god with the head of a hawk; a universal creator; he merged with the god Amen as Amen-Ra to become the king of the gods (同)Re

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1. 炎症性乳癌：病理および分子学的病因 inflammatory breast cancer pathology and molecular pathogenesis
2. 網膜色素変性症：臨床症状および診断 retinitis pigmentosa clinical presentation and diagnosis
3. ペプチドホルモンのシグナル伝達および調節 peptide hormone signal transduction and regulation
4. 糸球体足細胞のバイオロジー biology of glomerular podocytes
5. ネフロン癆の遺伝学および病因 genetics and pathogenesis of nephronophthisis

Intrinsic protein fluorescence assays for GEF, GAP and post-translational modifications of small GTPases.

Goody PR1.
Analytical biochemistry.Anal Biochem.2016 Dec 15;515:22-25. doi: 10.1016/j.ab.2016.09.019. Epub 2016 Sep 22.
Evidence and arguments are summarized that suggest that intrinsic (tryptophan) protein fluorescence provides an excellent and convenient signal for monitoring both GEF (guanine nucleotide exchange factor) and GAP (GTPase activating protein) activity of a large number of small GTPases. In addition, p
PMID 27665678

Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke.

Lucitti JL1, Sealock R1, Buckley BK1, Zhang H1, Xiao L1, Dudley AC1, Faber JE2.
Stroke.Stroke.2016 Dec;47(12):3022-3031. Epub 2016 Nov 3.
BACKGROUND AND PURPOSE: The extent (number and diameter) of collateral vessels varies widely and is a major determinant, along with arteriogenesis (collateral remodeling), of variation in severity of tissue injury after large artery occlusion. Differences in genetic background underlie the majority
PMID 27811335

Multiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast.

Madrid M1, Vázquez-Marín B1, Franco A1, Soto T1, Vicente-Soler J1, Gacto M1, Cansado J1.
Scientific reports.Sci Rep.2016 Nov 23;6:37515. doi: 10.1038/srep37515.
In eukaryotic cells, the highly conserved Target of Rapamycin (TOR) and the Mitogen Activated Protein Kinase (MAPK) signaling pathways elicit adaptive responses to extra- and intracellular conditions by regulating essential cellular functions. However, the nature of the functional relationships betw
PMID 27876895

Expression and intracellular localization of TBC1D9, a Rab GTPase-accelerating protein, in mice testes

NAKAMURA Yutaka,ASANO Atsushi,HOSAKA Yoshinao,TAKEUCHI Takashi,IWANAGA Toshihiko,YAMANO Yoshiaki
Experimental Animals advpub(0), 2015
… TBC family proteins work as Rab GTPase accelerating proteins (GAPs), which negatively regulate Rab proteins, to mediate membrane trafficking. … In this study, we analyzed the expression of a Rab GAP, TBC1D9, in mouse organs and the intracellular localization of the gene products. … Compartments that were positive for the constitutive active mutants of Rab7 and Rab9 were also positive for TBC1D9 isoform 1. …
NAID 130005083900

Yamaoka Mami,Ishizaki Toshimasa,Kimura Toshihide
Biological and Pharmaceutical Bulletin 38(5), 663-668, 2015
… Conventionally, only the guanosine 5′-triphosphate (GTP)-bound small GTPase interacts with effector proteins, and the resulting downstream signals control specific cellular functions. … The Rab family small GTPase Rab27a is highly expressed in some secretory cells and is involved in the control of membrane traffic. … The present study reviews recent progress in our understanding of the roles of Rab27a and its effectors in pancreatic beta-cells. …
NAID 130005068105