WordNet

a rise in the temperature of the body; frequently a symptom of infection (同)febrility, febricity, pyrexia, feverishness
intense nervous anticipation; "in a fever of resentment"
the 16th letter of the Roman alphabet (同)p
highly excited; "a fevered imagination"

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〈U〉《しばしばa fever》(身体の異常な)『熱』,発熱 / 〈U〉『熱病』 / 〈U〉〈C〉(…に対する)『興奮』,熱狂《+『for』+『名』》
parking
phosphorusの化学記号
(比較変化なし)《名詞の前にのみ用いて》熱のある,熱病にかかった / 熱にうかされたような,興奮した / (憎しみなどが)異常に強い

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/30 02:42:54」(JST)

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Pel-Ebstein fever, also known as Ebstein-Cardarelli fever,^[1] is a rarely seen condition noted in patients with Hodgkin's lymphoma in which the patient experiences fevers which cyclically increase then decrease over an average period of one or two weeks.^[2] A cyclic fever may also be associated with other conditions, but it is not called "Pel-Ebstein fever" unless the fever is associated with Hodgkin's.^[3]

Causes

The cause is currently unknown although speculation centers on host immune response - particularly the cyclical release of cytokines, lymph node necrosis, and damaged stromal cells.^[4]

Treatment

Treatment with non-steroidal anti-inflammatory agents or treatment of the underlying Hodgkin's (usually with chemotherapy) will help the symptoms.^[2]

Eponym

The condition is named after Wilhelm Ebstein and P.K. Pel who both published papers in 1887 noting the phenomenon.^[5]^[6]^[7] Both doctors published in the same journal, though Pel published first by several months. Interestingly, a long-term dispute persisted between Pel and Ebstein on the etiology of the condition.

Controversy

Researchers have speculated whether this condition truly exists, since some authorities anecdotally estimate only a 5-10% occurrence rate.^[3] In his Lettsomian Lecture Making Sense, delivered to the Medical Society of London in 1959, Richard Asher refers to Pel-Ebstein fever as an example of a condition that exists only because it has a name. "Every student and every doctor knows that cases of Hodgkin's disease may show a fever that is high for one week and low for the next week and so on. Does this phenomenon really exist at all?..." ^[8]

References

^ G.Fradà- Semeiotica Medica nell' adulto e nell'anziano. Piccin p.48
^ ^a ^b Mauch, Peter; James Armitage; Volker Diehl; Richard Hoppe; Laurence Weiss (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. pp. 327–328. ISBN 0-7817-1502-4.
^ ^a ^b "eMedicine - Pel-Ebstein Fever : Article by Ephraim P Hochberg, MD". Retrieved 2007-07-08.
^ Ree, HJ (1987). "Stromal macrophage-histiocytes in Hodgkin's disease. Their relation to fever". Cancer. 60 (1479): 1479–84. PMID 3621125. doi:10.1002/1097-0142(19871001)60:7<1479::AID-CNCR2820600713>3.0.CO;2-G.
^ Ebstein, Wilhelm (1887). "Das chronische Ruckfallsfieber, eine neue Infectionskrankheit". Berlin Klin Wochenschr. 24 (565).
^ Pel, PK (1887). "Pseudoleukaemie oder chronisches Ruckfallsfieber?". Berlin Klin Wochenschr. 24 (565).
^ synd/438 at Who Named It?
^ Hilson, A.J.W.; DiNubile, M.J. (1995-07-06). "Correspondence". New England Journal of Medicine. 333 (1): 66–67. PMID 7777006. doi:10.1056/NEJM199507063330118. Retrieved 2008-03-18. . They cite Richard Asher's lecture Making Sense (Lancet, 1959, 2, 359)

UpToDate Contents

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1. 成人における古典的ホジキンリンパ腫の初期評価および診断 initial evaluation and diagnosis of classical hodgkin lymphoma in adults
2. 癌が疑われる小児の臨床的評価 clinical assessment of the child with suspected cancer

English Journal

Pel-Ebstein cyclic fever: not just lymphoma.

Schattner A, Keshet N.
The American journal of medicine.Am J Med.2010 Jul;123(7):e3. doi: 10.1016/j.amjmed.2009.12.030.
PMID 20609672

[Clinical reasoning and decision making in practice. A 41-year old with periodic fever of unknown origin].

Koopmans RP, van den Born BJ, Kersten MJ, Hart W.SourceAcademisch Medisch Centrum/Universiteit van Amsterdam, afd. Inwendige Geneeskunde, Meibergdreef 9, 1105 AZ Amsterdam. r.p.koopmans@amc.uva.nl
Nederlands tijdschrift voor geneeskunde.Ned Tijdschr Geneeskd.2003 Sep 13;147(37):1778-83.
A 41-year-old man presented with unexplained bleeding from the right tonsil. He subsequently developed periodic fever, cervical lymphadenopathy and hepatosplenomegaly. Despite extensive bacteriological, serological and radiographic investigations for infectious disease, rheumatic disease and maligna
PMID 14526620

「ペル・エブスタイン熱」

Pel-Ebstein fever
Classification and external resources
eMedicine	med/1770
	[edit on Wikidata]

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英: Pel-Ebstein fever

熱型の中に波状熱(undulant fever):古典的ホジキンリンパ腫Hodgkin's lymphoma (HL)を含む悪性リンパ腫にみられるPel-Ebstein熱型が最も特徴的である。不規則な波状的発熱を繰り返す。3-10日間発熱が持続し、その後無熱期間が続き、再度高熱・無熱を繰り返す。

参考

http://blog.livedoor.jp/garjyusaiga/archives/52039307.html http://www1394.hp.infoseek.co.jp/igaku/naikasennmonni.html

「P」

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[1] G.Fradà- Semeiotica Medica nell' adulto e nell'anziano. Piccin p.48

[Mauch-2] Mauch, Peter; James Armitage; Volker Diehl; Richard Hoppe; Laurence Weiss (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. pp. 327–328. ISBN 0-7817-1502-4.

[Hochberg-3] "eMedicine - Pel-Ebstein Fever : Article by Ephraim P Hochberg, MD". Retrieved 2007-07-08.

[4] Ree, HJ (1987). "Stromal macrophage-histiocytes in Hodgkin's disease. Their relation to fever". Cancer. 60 (1479): 1479–84. PMID 3621125. doi:10.1002/1097-0142(19871001)60:7<1479::AID-CNCR2820600713>3.0.CO;2-G.

[5] Ebstein, Wilhelm (1887). "Das chronische Ruckfallsfieber, eine neue Infectionskrankheit". Berlin Klin Wochenschr. 24 (565).

[6] Pel, PK (1887). "Pseudoleukaemie oder chronisches Ruckfallsfieber?". Berlin Klin Wochenschr. 24 (565).

[WhoNamedIt-7] synd/438 at Who Named It?

[8] Hilson, A.J.W.; DiNubile, M.J. (1995-07-06). "Correspondence". New England Journal of Medicine. 333 (1): 66–67. PMID 7777006. doi:10.1056/NEJM199507063330118. Retrieved 2008-03-18. . They cite Richard Asher's lecture Making Sense (Lancet, 1959, 2, 359)

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Pel-Ebstein fever