English Journal

Barnacle Cement as Surface Anchor for 'Clicking' of Antifouling and Antimicrobial Polymer Brushes on Stainless Steel.

Yang WJ, Cai T, Neoh KG, Kang ET, Teo SL, Rittschof D.AbstractBarnacle cement (BC) was utilized 'beneficially' as a surface anchor on stainless steel (SS) for coupling of functional polymer brushes via 'click' reactions in both "grafting-to" and "grafting-from" processes. Ethylene sulfide (ES), propargyl carbonylimidazole (PPC) and azidoethyl carbonylimidazole (AEC) reacted with amine and/or hydroxyl groups in BC to introduce the corresponding thiol, alkyne and azide groups on SS surfaces (SS-thiol, SS-alkyne and SS-azide, respectively). Antifouling zwitterionic SS-PMPC surface was prepared by thiol-ene photopolymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) from the SS-thiol surface. Protein-resistant SS-PPEGMA and protein-adsorbing SS-PPFS surfaces were prepared by coupling of the respective azide-functionalized poly(poly(ethylene glycol)methyl ether methacrylate) (azido-PPEGMA) and poly(2,3,4,5,6-pentafluorostyrene) (azido-PPFS) polymer brushes in azide-alkyne 'click' reaction. Antifouling alkyne-functionalized poly(N-hydroxyethyl acrylamide) (alkynyl-PHEAA) and antibacterial alkyne-functionalized poly(2-(methacryloyloxy)ethyl trimethylammonium chloride) (alkynyl-PMETA) polymer brushes were clicked on the SS-azide surface. Adsorption of bovine serum albumin and bacteria fouling of Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus epidermidis (S. epidermidis) were investigated on the polymer-functionalized SS surfaces. The versatile bio-anchor and functional polymer brush coatings are stable in abiotic aqueous environment for over a month.
Biomacromolecules.Biomacromolecules.2013 May 3. [Epub ahead of print]
Barnacle cement (BC) was utilized 'beneficially' as a surface anchor on stainless steel (SS) for coupling of functional polymer brushes via 'click' reactions in both "grafting-to" and "grafting-from" processes. Ethylene sulfide (ES), propargyl carbonylimidazole (PPC) and azidoethyl carbonylimidazole
PMID 23641901

Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles.

Yu H, Zou Y, Jiang L, Yin Q, He X, Chen L, Zhang Z, Gu W, Li Y.SourceCenter of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Biomaterials.Biomaterials.2013 Apr;34(11):2738-47. doi: 10.1016/j.biomaterials.2012.12.042. Epub 2013 Jan 24.
Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer caused human death. In this work, we selected oncogene mouse double minute 2 (MDM2) as a therapeutic target for NSCLC treatment and proposed that sufficient MDM2 knockdown could inhibit tumor growth via induction of cell cyc
PMID 23352573

Enhanced drug delivery to melanoma cells using PMPC-PDPA polymersomes.

Pegoraro C, Cecchin D, Gracia LS, Warren N, Madsen J, Armes SP, Lewis A, Macneil S, Battaglia G.SourceThe Krebs Institute, University of Sheffield, Sheffield, UK; The Centre of Membrane Interaction and Dynamics, University of Sheffield, Sheffield, UK; The CRUK/YCR Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK; Department of Biomedical Sciences, University of Sheffield, Sheffield, UK; Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK; Kroto Research Institute, University of Sheffield, Sheffield, UK.
Cancer letters.Cancer Lett.2013 Feb 10. pii: S0304-3835(13)00118-3. doi: 10.1016/j.canlet.2013.02.007. [Epub ahead of print]
We present the efficient and stable encapsulation of doxorubicin within pH sensitive polymeric vesicles (polymersomes) for intracellular and nuclear delivery to melanoma cells. We demonstrate that PMPC25-PDPA70 polymersomes can encapsulate doxorubicin for long periods of time without significant dru
PMID 23402813

Japanese Journal

有機テルル化合物を用いたラジカル重合(TERP)による生体適合性ホスホリルコリン基を含むブロックコポリマーの合成 (特集号精密高分子合成の展望(1))

高分子論文集 = Japanese journal of polymer science and technology 72(5), 335-340, 2015
NAID 40020487441

有機テルル化合物を用いたラジカル重合(TERP)による生体適合性ホスホリルコリン基を含むブロックコポリマーの合成

高分子論文集 72(5), 335-340, 2015
NAID 130005070950

有機テルル化合物を用いたラジカル重合(TERP)による生体適合性ホスホリルコリン基を含むブロックコポリマーの合成

高分子論文集 advpub(0), 2015
NAID 130005061215

Related Pictures

PMPC Star Awards for TV - Members Church for tv 2013 winners bared pmpc star pmpc PMPC-SP - Sharp & Tappin Technology Ltd one of the trophies to be awarded on PMPC PMPC – Premolded Membrane Vapor Seal Dayton Audio PMPC-25 25uF 250V Precision Dayton Audio PMPC-15 15uF 250V Precision WINNERS: 2016 PMPC Star Awards for Movies