WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

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Increased Probability of Co-Occurrence of Two Rare Diseases in Consanguineous Families and Resolution of a Complex Phenotype by Next Generation Sequencing.

Lal D1,2,3, Neubauer BA2, Toliat MR1, Altmüller J1, Thiele H1, Nürnberg P1,3,4, Kamrath C5, Schänzer A6, Sander T1, Hahn A2, Nothnagel M1.
PloS one.PLoS One.2016 Jan 20;11(1):e0146040. doi: 10.1371/journal.pone.0146040. eCollection 2016.
Massively parallel sequencing of whole genomes and exomes has facilitated a direct assessment of causative genetic variation, now enabling the identification of genetic factors involved in rare diseases (RD) with Mendelian inheritance patterns on an almost routine basis. Here, we describe the illust
PMID 26789268

The roles of RgpB and Kgp in late onset gingipain activity in the vimA-defective mutant of Porphyromonas gingivalis W83.

Dou Y1, Robles A1, Roy F1, Aruni AW1, Sandberg L1, Nothnagel E2, Fletcher HM1,3.
Molecular oral microbiology.Mol Oral Microbiol.2015 Oct;30(5):347-60. doi: 10.1111/omi.12098. Epub 2015 May 8.
Previous studies have shown that VimA, an acetyltransferase, can modulate gingipain biogenesis in Porphyromonas gingivalis. Inactivation of the vimA gene resulted in isogenic mutants that showed a late onset of gingipain activity that only occurred during the stationary growth phase. To further eluc
PMID 25858089

2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry.

Bruder O1, Schneider S2, Pilz G3, van Rossum AC4, Schwitter J5, Nothnagel D6, Lombardi M7, Buss S8, Wagner A9, Petersen S10, Greulich S11, Jensen C12, Nagel E13, Sechtem U14, Mahrholdt H15.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.J Cardiovasc Magn Reson.2015 Jul 14;17:58. doi: 10.1186/s12968-015-0168-3.
OBJECTIVES: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population.BACKGROUND: We sought to re-evaluate the frequency, manifestations, and severity of acute adverse reactions associated with administra
PMID 26170152