N-メチルスコポラミン
WordNet
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- nitrogenの化学記号
- neodymiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/16 16:11:14」(JST)
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Methylscopolamine bromide
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Systematic (IUPAC) name |
(1R,2S,4R,5S,7R)-{[(2R)-3-hydroxy-2-phenylpropanoyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane
|
Clinical data |
Trade names |
Pamine, Extendryl, AlleRx, Rescon |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a606008 |
Pharmacokinetic data |
Biological half-life |
3–4 hrs |
Identifiers |
CAS Number |
155-41-9 |
ATC code |
A03BB03 S01FA03 |
PubChem |
CID: 441342 |
DrugBank |
DB00462 Y |
ChemSpider |
21106347 Y |
UNII |
RTN51LK7WL Y |
ChEMBL |
CHEMBL376897 Y |
Chemical data |
Formula |
C18H24NO4 |
Molecular mass |
318.388 g/mol |
SMILES
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OC[C@H](c1ccccc1)C(=O)O[C@H]2C[C@@H]3[N+](C)(C)[C@H](C2)[C@H]4O[C@@H]34
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InChI
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InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1 Y
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Key:LZCOQTDXKCNBEE-IKIFYQGPSA-N Y
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(verify) |
Methylscopolamine or methscopolamine, usually provided as the bromide salt (trade name Pamine), is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion.[1] Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications (trade names Extendryl, AlleRx, Rescon).
Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors.
References
- ^ Drugs.com: Methscopolamine
|
This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2009) |
Drugs for functional gastrointestinal disorders (A03)
|
|
Drugs for
functional
bowel disorders |
Antimuscarinics
|
Tertiary
amino group
|
- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
|
|
Quaternary
ammonium
compounds
|
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
|
|
|
Phosphodiesterase
inhibitors
|
- Papaverine
- Drotaverine
- Moxaverine
|
|
Acting on
serotonin receptors
|
- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
|
|
Other
|
- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
|
|
|
Belladonna
and derivatives
(antimuscarinics) |
- tertiary amines: Atropine
- Hyoscyamine
- quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
|
|
Propulsives |
- primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
|
|
Index of digestion
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|
Description |
- Anatomy
- Physiology
- Development
|
|
Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
|
|
Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
|
|
|
English Journal
- Altered trafficking and unfolded protein response induction as a result of M3 muscarinic receptor impaired N-glycosylation.
- Romero-Fernandez W, Borroto-Escuela DO, Perez Alea M, Garcia-Mesa Y, Garriga P.SourceCentre de Biotecnologia Molecular, Department d'Enginyeria Quimica, Universitat Politecnica de Catalunya, Spain. Email: (WRF) wilber.romero@upc.edu, (PG) pere.garriga@upc.edu.
- Glycobiology.Glycobiology.2011 Jul 28. [Epub ahead of print]
- The human M(3) muscarinic acetylcholine receptor is present in both the central and peripheral nervous system, and it is involved in the pathophysiology of several neurodegenerative and autoimmune diseases. We suggested a possible N-glycosylation map for M(3) muscarinic receptor expressed in COS-7 c
- PMID 21798865
- Influence of tissue integrity on pharmacological phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex.
- Anisuzzaman AS, Nishimune A, Yoshiki H, Uwada J, Muramatsu I.SourceDivision of Pharmacology, Department of Biochemistry and Bioinformative Sciences, School of Medicine.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2011 Jun 30. [Epub ahead of print]
- Distinct pharmacological phenotypes of muscarinic acetylcholine receptors (mAChRs) have been proposed. We compared the pharmacological profiles of mAChRs in intact segments and homogenates of rat cerebral cortex and other tissues by using radioligand binding assays with [(3)H]N-methylscopolamine ([(
- PMID 21719469
Japanese Journal
- Assessment of Novel Muscarinic Acetylcholine Receptors in Rat Cerebral Cortex by a Tissue Segment Binding Method
- LEE Kung-Shing,NISHIMUNE Atsushi,YOSHIKI Hatsumi,ANISUZZAMAN Abu Syed Md,SUZUKI Fumiko,WANG Mao-Hsien,CHENG Juei-Tang,MURAMATSU Ikunobu
- Journal of pharmacological sciences 112(4), 444-451, 2010-04-20
- … These mAChRs were a mixture of high- and low-affinity sites for N-methylscopolamine (NMS) in a 70:30 ratio. …
- NAID 10027909139
- Pharmacologically Relevant Receptor Binding Characteristics and 5α-Reductase Inhibitory Activity of Free Fatty Acids Contained in Saw Palmetto Extract(Pharmacology)
- ABE Masayuki,ITO Yoshihiko,OYUNZUL Luvsandorj,OKI-FUJINO Tomomi,YAMADA Shizuo
- Biological & pharmaceutical bulletin 32(4), 646-650, 2009-04-01
- … Also, lauric acid, oleic acid, myristic acid and linoleic acid inhibited specific [^3H]N-methylscopolamine ([^3H]NMS) binding in rat brain with IC_<50> …
- NAID 110007160688
Related Links
- N-Methylscopolamine information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: N-Methylscopolamine Description of N-Methylscopolamine N-Methylscopolamine
- Definition of N-Methylscopolamine in the Definitions.net dictionary. Meaning of N-Methylscopolamine. What does N-Methylscopolamine mean? Information and translations of N-Methylscopolamine in the most comprehensive ...
Related Pictures
★リンクテーブル★
[★]
- 英
- N-methylscopolamine
- 化
- メチル硫酸N-メチルスコポラミン N-methylscopolamine methylsulfate
- 商
- ダイピン
- 関
- メチルスコポラミン、methylscopolamine
[★]
メチル硫酸N-メチルスコ・ラミン
- 関
- N-methylscopolamine
[★]
- 関
- number of experiment、sample size
- pの前の[n]はmと記載する。synptom→symptom
[★]
[★]
N-メチルスコポラミン。メチルスコポラミン
[★]
ネオジム neodymium