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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/12 22:06:07」(JST)

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Methylscopolamine or methscopolamine, usually provided as the bromide salt (trade name Pamine), is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion.^[1] Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications (trade names Extendryl, AlleRx, Rescon).

Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors.

References

^ Drugs.com: Methscopolamine

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

English Journal

M2 Subtype preferring dibenzodiazepinone-type muscarinic receptor ligands: Effect of chemical homo-dimerization on orthosteric (and allosteric?) binding.

Keller M1, Tränkle C2, She X3, Pegoli A3, Bernhardt G3, Buschauer A3, Read RW4.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2015 Jul 15;23(14):3970-90. doi: 10.1016/j.bmc.2015.01.015. Epub 2015 Jan 14.
A series of new dibenzodiazepinone-type muscarinic receptor ligands, including two homo-dimeric compounds, was prepared. Sixteen representative compounds were characterized in equilibrium binding studies with [(3)H]N-methylscopolamine ([(3)H]NMS) at the muscarinic receptor subtype M2, and seven sele
PMID 25650309

50 years ago in The Journal of Pediatrics: congenital pyloric stenosis: a controlled evaluation of medical treatment utilizing methyl-scopolamine-nitrate.

Gisser JM1, Hill ID1.
The Journal of pediatrics.J Pediatr.2015 Mar;166(3):593. doi: 10.1016/j.jpeds.2014.09.044.
PMID 25722265

Coupling of g proteins to reconstituted monomers and tetramers of the M2 muscarinic receptor.

Redka DS1, Morizumi T2, Elmslie G3, Paranthaman P1, Shivnaraine RV1, Ellis J4, Ernst OP5, Wells JW6.
The Journal of biological chemistry.J Biol Chem.2014 Aug 29;289(35):24347-65. doi: 10.1074/jbc.M114.559294. Epub 2014 Jul 14.
G protein-coupled receptors can be reconstituted as monomers in nanodiscs and as tetramers in liposomes. When reconstituted with G proteins, both forms enable an allosteric interaction between agonists and guanylyl nucleotides. Both forms, therefore, are candidates for the complex that controls sign
PMID 25023280

Japanese Journal

Role of the third intracellular loop in the subtype-specific internalization and recycling of muscarinic M2 and M4 receptors

YOSHIDA Norihiro,JOJIMA Eri,SAITO Hiroyuki,HAGA Tatsuya
Biomedical Research 35(3), 185-192, 2014
… Muscarinic M2, M4, and M2-M4 chimera receptors were transiently expressed in HEK-293tsA201 cells, and agonist-dependent internalization of these receptors and recycling of internalizedreceptors were examined by measuring the amount of cell-surface receptors as [3H]N-methylscopolamine(NMS) binding activity. …
NAID 130004470866

Assessment of Novel Muscarinic Acetylcholine Receptors in Rat Cerebral Cortex by a Tissue Segment Binding Method

Lee Kung-Shing,Nishimune Atsushi,Yoshiki Hatsumi [他],ANISUZZAMAN Abu Syed Md,SUZUKI Fumiko,WANG Mao-Hsien,CHENG Juei-Tang,MURAMATSU Ikunobu
Journal of pharmacological sciences 112(4), 444-451, 2010-04-20
… These mAChRs were a mixture of high- and low-affinity sites for <I>N</I>-methylscopolamine (NMS) in a 70:30 ratio. …
NAID 10027909139

Pharmacologically Relevant Receptor Binding Characteristics and 5α-Reductase Inhibitory Activity of Free Fatty Acids Contained in Saw Palmetto Extract(Pharmacology)

Abe Masayuki,Ito Yoshihiko,Oyunzul Luvsandorj [他],OKI-FUJINO Tomomi,YAMADA Shizuo
Biological & pharmaceutical bulletin 32(4), 646-650, 2009-04-01
… Also, lauric acid, oleic acid, myristic acid and linoleic acid inhibited specific [^3H]N-methylscopolamine ([^3H]NMS) binding in rat brain with IC_<50> …
NAID 110007160688

Related Pictures

★リンクテーブル★

リンク元	「N-メチルスコポラミン」
拡張検索	「N-methylscopolamine methylsulfate」「N-methylscopolamine」

「N-メチルスコポラミン」

Methylscopolamine bromide
Systematic (IUPAC) name
	(1R,2S,4R,5S,7R)-{[(2R)-3-hydroxy-2-phenylpropanoyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane
Clinical data
Trade names	Pamine, Extendryl, AlleRx, Rescon
AHFS/Drugs.com	monograph
MedlinePlus	a606008
Pharmacokinetic data
Biological half-life	3–4 hrs
Identifiers
CAS Registry Number	155-41-9
ATC code	A03BB03 S01FA03
PubChem	CID: 441342
DrugBank	DB00462
ChemSpider	21106347
UNII	RTN51LK7WL
ChEMBL	CHEMBL376897
Chemical data
Formula	C18H24NO4
Molecular mass	318.388 g/mol
	SMILES OC[C@H](c1ccccc1)C(=O)O[C@H]2C[C@@H]3[N+](C)(C)[C@H](C2)[C@H]4O[C@@H]34 ;
	InChI InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1 ; Key:LZCOQTDXKCNBEE-IKIFYQGPSA-N ;
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