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English Journal

Response to low-dose bortezomib in plasma cell leukemia patients with malignant pleural effusion and ascites: a case report and a review of the literature.

Sekiguchi Y, Shirane S, Imai H, Sugimoto K, Wakabayashi M, Sawada T, Chigira N, Ichikawa K, Komatsu N, Noguchi M.SourceDivision of Hematology, Juntendo University Urayasu Hospital, Japan. yasu_sek@juntendo-urayasu.jp
Internal medicine (Tokyo, Japan).Intern Med.2012;51(11):1393-8. Epub 2012 Jun 1.
Pleural effusion or ascites complicating plasmacytoma is rare and has a poor prognosis. A 70-year-old man was diagnosed as plasma cell leukemia and one course of ranimustine-vindesine, melphalan, and prednisolone followed by melphalan and prednisone (MP) maintained a very good partial response. Afte
PMID 22687849

Ranimustine, ifosfamide, procarbazine, dexamethasone, and etoposide therapy for central nervous system recurrence of diffuse large B-cell lymphoma in patients with poor performance status: a pilot study.

Miwa A, Sekiguchi N, Tanimura A, Homma C, Shikai T, Takezako Y, Yamagata N, Takezako N.SourceDepartment of Hematology, National Center for Global Health and Medicine, Tokyo, Japan.
Leukemia & lymphoma.Leuk Lymphoma.2011 Oct;52(10):1898-903. Epub 2011 Jun 8.
The prognosis of patients with diffuse large B-cell lymphoma with central nervous system (CNS) involvement is still poor. We performed a pilot study to establish treatment for patients who had refractory or recurrent CNS involvement without employing high-dose chemotherapy or stem cell support. Eigh
PMID 21649542

若林俊彦
Neuro-Oncologyの進歩 21(3), 45-50, 2014
… especially glioblastoma (GBM), the most common glioma in adults, kills patients within a median time span of a year after diagnosis despite treatment with aggressive surgical resection, chemotherapy, and radiotherapy.In Japan, alkylating agents such as 1- (4-amino-2-methyl-5-pyridiminyl) methyl-3- (2-chloroethyl) -3-nitrosourea (ACNU) and methyl-6-[3- (2-chloroethyl) -3-nitrosoureido] -6-deoxy-alpha-D-glucopyranoside (MCNU) have been used to treatmalignant gliomas for a long time, however, this treatment offered few clinical benefits.Temozolomide …
NAID 130005002163

Safety and feasibility of high-dose ranimustine (MCNU), carboplatin, etoposide, and cyclophosphamide (MCVC) therapy followed by autologous stem cell transplantation for malignant lymphoma

KAMEOKA Yoshihiro,TAKAHASHI Naoto,ISHIZAWA Kenichi,KATO Yuichi,ITO Jugo,SASAKI Osamu,MURAI Kazunori,NOJI Hideyoshi,HIROKAWA Makoto,TAJIMA Katsusi,SHICHISHIMA Tsutomu,ISHIDA Yoji,HARIGAE Hideo,SAWADA Kenichi
International journal of hematology 96(5), 624-630, 2012-11-01
NAID 10031126760

窪田良次,脇正人
臨床血液 50(3), 197-202, 2009
症例は61歳女性。1987年8月，本態性血小板血症と診断（45歳時）され，心筋梗塞の既往があるためbusulfanおよびranimustine投与が行われた（総投与量は，378 mgおよび700 mg）。2000年6月頃より，貧血の進行と末梢血中に数%の芽球を認めるようになった。骨髄生検にて骨髄線維症と診断し，蛋白同化ホルモンの治療を開始した。2003年2月，腹部膨満感を自覚するようになり，腹部C …
NAID 130004501326