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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/31 00:11:57」(JST)
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Activating transcription factor 7 interacting protein |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
2RPQ
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|
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Identifiers |
Symbols |
ATF7IP ; AM; ATF-IP; MCAF; MCAF1; p621 |
External IDs |
OMIM: 613644 MGI: 1858965 HomoloGene: 10051 GeneCards: ATF7IP Gene |
Gene ontology |
Molecular function |
• transcription corepressor activity
• protein binding
• ATPase activity
|
Cellular component |
• nucleus
• nucleoplasm
• transcription factor complex
• cytoplasm
|
Biological process |
• negative regulation of transcription from RNA polymerase II promoter
• DNA methylation
• chromatin organization
• transcription, DNA-templated
• viral process
• negative regulation of transcription, DNA-templated
• positive regulation of transcription, DNA-templated
• regulation of RNA polymerase II transcriptional preinitiation complex assembly
|
Sources: Amigo / QuickGO |
|
RNA expression pattern |
|
More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
55729 |
54343 |
Ensembl |
ENSG00000171681 |
ENSMUSG00000030213 |
UniProt |
Q6VMQ6 |
Q7TT18 |
RefSeq (mRNA) |
NM_001286514 |
NM_019426 |
RefSeq (protein) |
NP_001273443 |
NP_062299 |
Location (UCSC) |
Chr 12:
14.37 – 14.5 Mb |
Chr 6:
136.52 – 136.61 Mb |
PubMed search |
[1] |
[2] |
|
Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.[1][2][3]
Interactions
ATF7IP has been shown to interact with MBD1.[4]
References
- ^ Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
- ^ De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215.
- ^ "Entrez Gene: ATF7IP activating transcription factor 7 interacting protein".
- ^ Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Ohkuma Yoshiaki; Chiba Tsutomu; Saya Hideyuki; Nakao Mitsuyoshi (Apr 2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. (United States) 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. ISSN 0270-7306. PMC 152570. PMID 12665582.
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yamada K, Kawata H, Shou Z et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632.
- Fujita N, Watanabe S, Ichimura T et al. (2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8): 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. PMC 152570. PMID 12665582.
- Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
- Wang H, An W, Cao R et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression". Mol. Cell 12 (2): 475–87. doi:10.1016/j.molcel.2003.08.007. PMID 14536086.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ichimura T, Watanabe S, Sakamoto Y et al. (2005). "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins". J. Biol. Chem. 280 (14): 13928–35. doi:10.1074/jbc.M413654200. PMID 15691849.
- Chang LK, Chung JY, Hong YR et al. (2005). "Activation of Sp1-mediated transcription by Rta of Epstein–Barr virus via an interaction with MCAF1". Nucleic Acids Res. 33 (20): 6528–39. doi:10.1093/nar/gki956. PMC 1298921. PMID 16314315.
- Uchimura Y, Ichimura T, Uwada J et al. (2006). "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation". J. Biol. Chem. 281 (32): 23180–90. doi:10.1074/jbc.M602280200. PMID 16757475.
- Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
English Journal
- The Use of Platelet-Rich Fibrin Versus Subepithelial Connective Tissue Graft in Treatment of Multiple Gingival Recessions: A Randomized Clinical Trial.
- Öncü E.
- The International journal of periodontics & restorative dentistry.Int J Periodontics Restorative Dent.2017 Mar/Apr;37(2):265-271. doi: 10.11607/prd.2741.
- The objective of this study was to evaluate the clinical effectiveness of platelet-rich fibrin (PRF) membrane used in combination with a modified coronally advanced flap (MCAF) and to compare it with the use of a subepithelial connective tissue graft (SCTG) in combination with a MCAF in treatment of
- PMID 28196169
- mCAF: a multi-dimensional clustering algorithm for friends of social network services.
- Chang HT1, Li YW1, Mishra N1.
- SpringerPlus.Springerplus.2016 Jun 17;5(1):757. doi: 10.1186/s40064-016-2420-1. eCollection 2016.
- PMID 27386242
- Isolation and Structure Determination of 24-Methylenecycloartanyl Ferulate from Indian Rice Bran and Its Quantitative Analysis.
- Muthal AP1, Rojatkar SR2, Bodhankar SL1.
- Pharmacognosy magazine.Pharmacogn Mag.2016 May;12(Suppl 3):S307-14. doi: 10.4103/0973-1296.185722.
- PMID 27563217
Japanese Journal
- Chemokines in inflammatory and immune diseases
- Matsushima Kouji,Terashima Yuya,Toda Etsuko,Shand Francis,Ueha Satoshi
- Inflammation and Regeneration 31(1), 11-22, 2011
- … Nearly two decades have passed since our discovery of the prototypic chemokines, a neutrophil chemotactic factor interleukin 8 (IL 8, CXCL8) and monocyte chemotactic factor MCAF/MCP-1 (CCL2) at the National Cancer Institute, USA. …
- NAID 130004943765
- A Real-Time SUMO-Binding Assay for the Analysis of the SUMO-SIM Protein Interaction Network
- Tanaka Niina,Saitoh Hisato
- Bioscience, biotechnology, and biochemistry 74(6), 1302-1305, 2010-06-23
- … Using this assay, we investigated the SIMs in SETDB1 and MCAF1 to gain insight into the assembly of SETDB1-MCAF1-mediated gene silencing. …
- NAID 10027556707
- Antioxidant, Free Radical-Scavenging, and NF-κB-Inhibitory Activities of Phytosteryl Ferulates : Structure-Activity Studies
- Islam Md. Shafiqul,Yoshida Hiroshi,Matsuki Naoaki [他],ONO Kenichiro,NAGASAKA Reiko,USHIO Hideki,GUO Ying,HIRAMATSU Toshiyuki,HOSOYA Takamitsu,MURATA Takahisa,HORI Masatoshi,OZAKI Hiroshi
- Journal of pharmacological sciences 111(4), 328-337, 2009-12-20
- … In this study, 2,2-diphenyl-1-picrylhydrazyl (DPPH), electron spin resonance (ESR), and thiobarbituric acid–reactive substances (TBARS) assays demonstrated that phytosteryl ferulates such as cycloartenyl ferulate (CAF), 24-methylenecycloartanyl ferulate (24-mCAF), and β-sitosteryl ferulate (β-SF) and ferulic acid (FA) each exerted strong free radical scavenging and antioxidation of lipid membrane, which were comparable to α-tocopherol. …
- NAID 10026154412
Related Pictures
★リンクテーブル★
[★]
- 英
- monocyte chemotactic and activating factor, MCAF
- 同
- 単球走化性/活性化因子
- 関
- 単球遊走因子、単球活性化因子、単球
[★]
[★]
中大脳動脈 middle cerebral artery