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a way of doing something, especially a systematic way; implies an orderly logical arrangement (usually in steps)

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1. 乳幼児および思春期前の小児における通常の成長パターン normal growth patterns in infants and prepubertal children
2. 在胎月齢の生後評価 postnatal assessment of gestational age
3. Fertility awareness法での避妊 fertility awareness based methods of pregnancy prevention
4. 低身長の小児および思春期患者に対する診断的アプローチ diagnostic approach to children and adolescents with short stature
5. 腰痛の運動療法 exercise based therapy for low back pain

Indomethacin-loaded methoxy poly(ethylene glycol)/poly(D,L-lactide) amphiphilic diblock copolymeric nanospheres: pharmacokinetic and toxicity studies in rodents.

Kim SY1, Lee YM, Kang JS.
Journal of biomedical materials research. Part A.J Biomed Mater Res A.2005 Sep 15;74(4):581-90.
Biodegradable methoxy poly(ethylene glycol)/poly(D,L-lactide) amphiphilic block copolymeric nanospheres were prepared for application as a particulate drug carrier. Drug-loaded nanospheres (ML50) showed a narrow size distribution with the average diameter of <200 nm. When the feed weight ratio of
PMID 16025473

Cisplatin incorporated in microspheres: development and fundamental studies for its clinical application.

Fujiyama J1, Nakase Y, Osaki K, Sakakura C, Yamagishi H, Hagiwara A.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2003 May 20;89(3):397-408.
A new drug delivery formulation, biodegradable glycolic acid-lactic acid copolymer (PGLA) microspheres incorporating cisplatin (CDDP-MS) has been developed for the treatment of peritoneal carcinomatosis. Scanning electron microscopy showed that CDDP-MS has a smooth surface and few cisplatin crystals
PMID 12737842

Toxic characteristics of methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) nanospheres; in vitro and in vivo studies in the normal mice.

Kim SY1, Lee YM, Baik DJ, Kang JS.
Biomaterials.Biomaterials.2003 Jan;24(1):55-63.
Amphiphilic diblock polymeric nanospheres composed of methoxy poly(ethylene glycol) (MePEG) and poly(epsilon-caprolactone)(PCL) was prepared for application as a novel drug carrier. We could obtain the MePEG/PCL nanospheres that exhibited an average diameter of less than 200 nm with narrow size dist
PMID 12417178

Effects of Oral Acute Administration and Subchronic Feeding of Several Levels of D-Psicose in Rats

Matsuo Tatsuhiro,Tanaka Tomohiro,Hashiguchi Mineo,IZUMORI Ken,SUZUKI Hiroo
Journal of nutritional science and vitaminology 48(6), 512-516, 2002-12-01
… The calculated LD50 values were 16.3g/kg by the Behrens-Karber method and 15.8g/kg by the Litchfield-Wilcoxon method. …
NAID 130001377233

Acute toxicity of aclarubicin adsorbed on carbon particles injected subcutaneously in mice.

松本章二,岩本昭彦,米山千尋,萩原明於,高橋俊雄,吉川広之,村西昌三
Drug Delivery System 6(1), 41-45, 1991
… The LD50 values of ACR-CH and ACR-SOL calculated following Litchfield-Wilcoxon method were 83.5 mg/kg and 43.5 mg/kg, respectively. …
NAID 130000747551

大住伴子
九州齒科學會雜誌 : Kyushu-Shika-Gakkai-zasshi 44(5), 771-787, 1990-10-25
… In the first biological study the antimicrobial effect was tested on five kinds of strains by the paper disc method. … with confidence limits was calculated with use of Litchfield-Wilcoxon's method. …
NAID 110003004656