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The phosphoproteome of human Jurkat T cell clones upon costimulation with anti-CD3/anti-CD28 antibodies.

Nguyen TD1, Carrascal M2, Vidal-Cortes O2, Gallardo O2, Casas V2, Gay M2, Phan VC3, Abian J4.
Journal of proteomics.J Proteomics.2016 Jan 10;131:190-8. doi: 10.1016/j.jprot.2015.10.029. Epub 2015 Nov 3.
Phosphorylation is a reversible post-translational modification, playing a vital role in protein function. In T cells, protein phosphorylation is the key mechanism regulating T cell receptor-driven signaling pathways. In order to gain insights into the phosphoproteome evolution of T cell activation,
PMID 26546556

Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.

Fuller JA1, Berlinicke CA2, Inglese J3, Zack DJ4.
Advances in experimental medicine and biology.Adv Exp Med Biol.2016;854:597-603. doi: 10.1007/978-3-319-17121-0_79.
High content analysis (HCA) has become a leading methodology in phenotypic drug discovery efforts. Typical HCA workflows include imaging cells using an automated microscope and analyzing the data using algorithms designed to quantify one or more specific phenotypes of interest. Due to the richness o
PMID 26427464

Patry M1, Teinturier R1, Goehrig D1, Zetu C2, Ripoche D1, Kim IS3, Bertolino P1, Hennino A4.
Diabetes.Diabetes.2015 Dec;64(12):4212-9. doi: 10.2337/db15-0638. Epub 2015 Oct 15.
βig-h3/TGF-βi is a secreted protein capable of binding to both extracellular matrix and cells. Human genetic studies recently revealed that in the tgfbi gene encoding for βig-h3, three single nucleotide polymorphisms were significantly associated with type 1 diabetes (T1D) risk. Pancreatic islets
PMID 26470788

Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice

Ikebe Emi,Kawaguchi Akira,Tezuka K,Taguchi S,Hirose S,Matsumoto Takashi,Mitsui Takahiro,Senba K,Nishizono Akira,Hori Mitsuo,Hasegawa Hiroo,Yamada Y,Ueno T,Tanaka Yuetsu,Sawa H,Hall William W.,Minami Yasufumi,Jeang K. T.,Ogata Masao,Morishita K,Hasegawa Hideki,Fujisawa J,Iha Hidekatsu
Blood Cancer Journal 3(8), e132, 2013-08-16
… Tax interacts with the I κB kinase regulatory subunit NEMO (NF-κB essential modulator) to activate NF-κB, and this interaction is maintained in part by a molecular chaperone, heat-shock protein 90 (HSP90), and its co-chaperone cell division cycle 37 (CDC37). …
NAID 120005328271

Roles of the Src family kinase Lck in Toll-like receptor 2 signaling triggered by stimulation with a mycoplasma derived lipopeptide

Effects of Halogenation on Tyrosine Phosphorylation and Peptide Binding to the Src Homology 2 Domain of Lymphocyte-Specific Protein Tyrosine Kinase

Okamura Toshimitsu,Kikuchi Tatsuya,Nodaira Mika [他],Odaka Kenichi,Fukushi Kiyoshi,Irie Toshiaki
Biological and Pharmaceutical Bulletin 35(3), 433-437, 2012
… It has been reported that nitration of tyrosine residue caused peptides to be a poor substrate for PTK and that nitrotyrosine residues could bind to SH2 domains as a phosphotyrosine mimic to activate Src family kinase. …
NAID 130001872328