WordNet
- an investigation of the component parts of a whole and their relations in making up the whole
- the abstract separation of a whole into its constituent parts in order to study the parts and their relations (同)analytic thinking
- a branch of mathematics involving calculus and the theory of limits; sequences and series and integration and differentiation
- a form of literary criticism in which the structure of a piece of writing is analyzed
- the use of closed-class words instead of inflections: e.g., `the father of the bride instead of `the brides father
- a state of surviving; remaining alive (同)endurance
- a natural process resulting in the evolution of organisms best adapted to the environment (同)survival of the fittest, natural_selection, selection
- something that survives
PrepTutorEJDIC
- (内容・状況などの)『分析』,分解;(詳細な)検討 / (化学・物理で)分析;《米》(心理学で)[精神]分析;(数学で)解析
- 〈U〉(…が)生き残ること,(…の)生存,残存《+of+名》 / 〈C〉生存者,残存者;残存物,遺物
UpToDate Contents
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English Journal
- Analysis of 320 gastroenteropancreatic neuroendocrine tumors identifies TS expression as independent biomarker for survival.
- Lee HS1, Chen M, Kim JH, Kim WH, Ahn S, Maeng K, Allegra CJ, Kaye FJ, Hochwald SN, Zajac-Kaye M.Author information 1Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea.AbstractThymidylate synthase (TS), a critical enzyme for DNA synthesis and repair, is both a potential tumor prognostic biomarker as well as a tumorigenic oncogene in animal models. We have now studied the clinical implications of TS expression in gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) and compared these results to other cell cycle biomarker genes. Protein tissue arrays were used to study TS, Ki-67, Rb, pRb, E2F1, p18, p21, p27 and menin expression in 320 human GEP-NETs samples. Immunohistochemical expression was correlated with univariate and multivariate predictors of survival utilizing Kaplan Meier and Cox proportional hazards models. Real time RT-PCR was used to validate these findings. We found that 78 of 320 GEP-NETs (24.4%) expressed TS. NETs arising in the colon, stomach and pancreas showed the highest expression of TS (47.4%, 42.6% and 37.3%, respectively), whereas NETs of the appendix, rectum and duodenum displayed low TS expression (3.3%, 12.9% and 15.4%, respectively). TS expression in GEP-NETs was associated with poorly differentiated endocrine carcinoma, angiolymphatic invasion, lymph node metastasis and distant metastasis (p < 0.05). Patients with TS-positive NETs had markedly worse outcomes than TS-negative NETs as shown by univariate (p < 0.001) and multivariate (p = 0.01) survival analyses. Expression of p18 predicted survival in TS-positive patients that received chemotherapy (p = 0.015). In conclusion, TS protein expression was an independent prognostic biomarker for GEP-NETs. The strong association of increased TS expression with aggressive disease and early death supports the role of TS as a cancer promoting agent in these tumors.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Jul 1;135(1):128-37. doi: 10.1002/ijc.28675. Epub 2014 Jan 6.
- Thymidylate synthase (TS), a critical enzyme for DNA synthesis and repair, is both a potential tumor prognostic biomarker as well as a tumorigenic oncogene in animal models. We have now studied the clinical implications of TS expression in gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) an
- PMID 24347111
- The expression and phosphorylation of ezrin and merlin in human pancreatic cancer.
- Zhou J1, Feng Y1, Tao K1, Su Z2, Yu X3, Zheng J4, Zhang L5, Yang D1.Author information 1Department of General Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, P.R. China.2Basic Medical Research Center, Qinghai University, Xining 810001, P.R. China.3Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, P.R. China.4Department of Pathology, School of Medicine, Southeast University, Nanjing 210009, P.R. China.5Department of Surgical Pathology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, P.R. China.AbstractPancreatic carcinoma is the most common pancreatic malignancy and is associated with a very poor prognosis. Therefore, new prognostic factors and new treatment strategies are clearly needed. In this study, we retrospectively studied the levels of phosphorylated ezrin in 19 patients with pancreatic carcinoma by immunohistochemical analysis and determined the correlation between protein expression, clinicopathological characteristics and prognosis in pancreatic adenocarcinoma. We also characterized the phenotype of the overexpression of wild-type and phosphorylated ezrin and merlin in human pancreatic cancer cell lines. A significant correlation between the levels of phosphorylated ezrin 353 and ezrin 567 and the stage of pancreatic cancer was observed. Moreover, Kaplan-Meier analysis revealed that patients with high levels of phosphorylated ezrin had a significantly poorer survival rate (P<0.05). In addition, the overexpression of wild-type merlin or ezrin inhibited cell proliferation, migration and adhesion. However, the overexpression of T567D ezrin, a mutant that mimics permanent phosphorylation, promoted the proliferation, adhesion and migration of the pancreatic adenocarcinoma cell line SW1990. The overexpression of S518D merlin inhibited the growth of SW1990 and did not affect migration or adhesion. These results suggest that the phosphorylation of ezrin may contribute to the progression of pancreatic carcinoma and that the level of phosphorylated ezrin may serve as an adverse prognostic factor for pancreatic carcinoma.
- International journal of oncology.Int J Oncol.2014 Jun;44(6):2059-67. doi: 10.3892/ijo.2014.2381. Epub 2014 Apr 10.
- Pancreatic carcinoma is the most common pancreatic malignancy and is associated with a very poor prognosis. Therefore, new prognostic factors and new treatment strategies are clearly needed. In this study, we retrospectively studied the levels of phosphorylated ezrin in 19 patients with pancreatic c
- PMID 24728215
- The expression of miR-30a* and miR-30e* is associated with a dualistic model for grading ovarian papillary serious carcinoma.
- Wang Y1, Li L2, Qu Z3, Li R4, Bi T5, Jiang J5, Zhao H3.Author information 1Laboratory Center, Second Affiliated Hospital of Dalian Medical University, Dalian, P.R. China.2Department of Pathology, Second Affiliated Hospital of Dalian Medical University, Dalian, P.R. China.3Department of Pathophysiology, Dalian Medical University, Dalian, P.R. China.4Department of Anesthesiology, Second Affiliated Hospital of Dalian Medical University, Dalian, P.R. China.5Obstetrics and Gynecology Hospital, Dalian, P.R. China.AbstractHistological grade has already been recognized as a very important prognostic factor for ovarian papillary serous carcinoma (OPSC). On the basis of pathogenetic mechanisms, recent findings suggest a dualistic model of OPSC consisting of types I (low-grade) and II (high-grade) cancers. High-grade OPSC is responsible for most ovarian cancer deaths. The goal of our investigation was to identify the differences in key miRNAs and possible regulators through miRNA microarray chip analysis, as well as functional target prediction and clinical outcome between the low and high-grade OPSC patients. The pathogenic basis in differentiation of ovarian cancer subtypes was studied to provide insight into diagnosis and therapy for high-grade cases. Through microarray analysis, we found that miR-30a* and miR-30e* were the top 2 significantly different miRNAs between type I and type II OPSC patients, and both were remarkably downregulated in the latter type. ATF3 and MYC were indicated as potential co-targets of miR-30a* and miR-30e*, and showed a significant upregulation in type II patients. As ATF3 and MYC are often associated with aggressive behavior and poor differentiation, especially in human cancers, these results are in good agreement with our findings and point toward a regulating differentiation function of the miR-30a* and miR-30e* genes. Further analysis using leave‑one-out cross predictions and Kaplan-Meier survival analysis strongly suggested that miR-30a* and miR-30e* can be used as biomarkers to tailor histological grade before starting the regimen, and they showed important roles in ovarian cancer differentiation resulting in poorer prognosis. In general, miR-30a* and miR-30e* coupled with expression data that reveal pathogenic regulation to predict histological differentiation, may operate to direct the formation of early detection and therapeutic approaches to individual OPSC patients, especially differentiation therapy to high-grade cases.
- International journal of oncology.Int J Oncol.2014 Jun;44(6):1904-14. doi: 10.3892/ijo.2014.2359. Epub 2014 Mar 27.
- Histological grade has already been recognized as a very important prognostic factor for ovarian papillary serous carcinoma (OPSC). On the basis of pathogenetic mechanisms, recent findings suggest a dualistic model of OPSC consisting of types I (low-grade) and II (high-grade) cancers. High-grade O
- PMID 24676806
Japanese Journal
- 転移性淡明腎細胞癌に対する分子標的薬の効果と予後因子の検討
- 井上 隆太,北村 寛,進藤 哲哉 [他],柳瀬 雅裕,高橋 敦,宮尾 則臣,伊藤 直樹,堀田 裕,広瀬 崇興,田口 圭介,松川 雅則,上原 央久,国島 康晴,堀田 浩貴,舛森 直哉
- 泌尿器科紀要 = Acta urologica Japonica 61(4), 135-139, 2015-04
- … Cancer-specific survival was analyzed using the Kaplan-Meier method. … Predictors of cancer-specific survival were analyzed using the Cox regression hazards model. … A total of 89 patients, consisting of 50 first line patients and 39 patients receiving prior cytokine were included in the analysis. …
- NAID 120005611428
- 進行舌癌および舌根癌に対する舌喉頭全摘出術に関する検討
- 濱 孝憲,佐々木 徹,川端 一嘉,三谷 浩樹,米川 博之,福島 啓文,新橋 渉,瀬戸 陽,神山 亮介,蛯名 彩
- 日本耳鼻咽喉科学会会報 118(6), 745-750, 2015
- 当院では舌や舌根原発の極めて進行した悪性腫瘍に対する初回治療およびその再発症例に対する救済治療の一つとして舌喉頭全摘出術を施行してきた. 今回2005年1月から2013年6月までに舌喉頭全摘術を施行した口腔癌 (25例), 中咽頭癌 (4例) の検討を行った. 具体的には (1) 治療成績 (2) 術後予後因子 (3) 初回治療症例と救済症例の転帰 (4) 局所制御について検討した. 初回治療症 …
- NAID 130005088295
- 重度認知症を合併した血液透析患者における精神科入院後の予後の検討
- 齋藤 友季子,向井 賢司,貴志 直哉,川口 茂,齋藤 真一,齋藤 純一
- 日本透析医学会雑誌 48(6), 361-364, 2015
- … 2群間において, 患者背景を調査し, 精神科入院後の予後を, Kaplan-Meier生存曲線を用いて比較検討した. …
- NAID 130005085284
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