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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/28 16:00:00」(JST)

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Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca²⁺ channel activated by inositol trisphosphate (InsP3). InsP3R is very diverse among organisms, and is necessary for the control of cellular and physiological processes including cell division, cell proliferation, apoptosis, fertilization, development, behavior, learning and memory.^[2] Inositol triphosphate receptor represents a dominant second messenger leading to the release of Ca²⁺ from intracellular store sites. There is strong evidence suggesting that the InsP3R plays an important role in the conversion of external stimuli to intracellular Ca²⁺ signals characterized by complex patterns relative to both space and time. For example, Ca²⁺ waves and oscillations.^[3] The InsP3 receptor was first purified from rat cerebellum by neuroscientists Surachai Supattapone and Solomon Snyder at Johns Hopkins University School of Medicine. ^[4]

Distribution

It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the InsP3Rs are found in the cell integrated into the endoplasmic reticulum.

Structure

The asymmetric structure consists of an N-terminal beta-trefoil domain and a C-terminal alpha helical domain with a folding pattern similar to an armadillo repeat fold. The split formed by the two terminals contains multiple arginine and lysine residues that coordinate the three phosphoryl groups of InsP3.^[2] The InsP3R complex is formed of four 313 kDa subunits. In amphibians, fish and mammals there are 3 paralogs and these can form homo- or hetero-oligomers. InsP3R-1 is the most widely expressed of these three and is found in all tissue types and all developmental stages of life. It is additionally the means for further InsP3 receptor diversity in that it has as many as four splice sites with as many as 9 different optional exons or exon variants. Combinations of these can be introduced into a given transcript in order to modulate its pharmacological activity.

References

^ Bosanac I, Yamazaki H, Matsu-Ura T, Michikawa T, Mikoshiba K, Ikura M (January 2005). "Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor". Mol. Cell 17 (2): 193–203. doi:10.1016/j.molcel.2004.11.047. PMID 15664189.
^ ^a ^b Bosanac I, Alattia JR, Mal TK et al. (December 2002). "Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand". Nature 420 (6916): 696–700. doi:10.1038/nature01268. PMID 12442173.
^ Yoshida Y, Imai S (June 1997). "Structure and function of inositol 1,4,5-trisphosphate receptor". Jpn. J. Pharmacol. 74 (2): 125–37. doi:10.1254/jjp.74.125. PMID 9243320.
^ Supattapone S, et al. J Biol Chem. 1988 Jan 25;263(3):1530-4.

External links

Inositol Trisphosphate Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

English Journal

Occurrence of gustducin-immunoreactive cells in von Ebner's glands of guinea pigs.

Ibira Y, Yokosuka H, Haga-Tsujimura M, Yoshie S.SourceDepartment of Histology, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata, 951-8580, Japan.
Histochemistry and cell biology.Histochem Cell Biol.2013 Nov;140(5):567-74. doi: 10.1007/s00418-013-1094-9. Epub 2013 Apr 19.
An immunohistochemical examination of guinea-pig taste buds in vallate papillae revealed gustducin-immunoreactive cells in the area of von Ebner's glands, minor salivary glands. Since there have been no reports describing those cells in these locations for other species, we investigated these glands
PMID 23604549

Modulation effect of Smilax glabra flavonoids on ryanodine receptor mediated intracellular Ca(2+) release in cardiomyoblast cells.

Shou Q, Pan S, Tu J, Jiang J, Ling Y, Cai Y, Chen M, Wang D.SourceExperimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Journal of ethnopharmacology.J Ethnopharmacol.2013 Oct 28;150(1):389-92. doi: 10.1016/j.jep.2013.08.009. Epub 2013 Aug 14.
ETHNOPHARMACOLOGICAL RELEVANCE: Smilax glabra rhizome, a plant material from Liliaceae family, is a widely used traditional Chinese medicine for anti-cardiac hypertrophy treatment. We have previously found that Smilax glabra flavonoids (SGF) exerted such anti-cardiac hypertrophy activity. However, t
PMID 23954280

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

Alzayady KJ, Wagner LE 2nd, Chandrasekhar R, Monteagudo A, Godiska R, Tall GG, Joseph SK, Yule DI.SourceFrom the Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642.
The Journal of biological chemistry.J Biol Chem.2013 Oct 11;288(41):29772-84. doi: 10.1074/jbc.M113.502203. Epub 2013 Aug 16.
Vertebrate genomes code for three subtypes of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R1, -2, and -3). Individual IP3R monomers are assembled to form homo- and heterotetrameric channels that mediate Ca(2+) release from intracellular stores. IP3R subtypes are regulated differentially by IP3,
PMID 23955339

Japanese Journal

TRIC(trimeric intracellular cation)-Aチャネルは血管平滑筋において血圧調節に寄与する

山崎大樹
YAKUGAKU ZASSHI 132(9), 1037-1043, 2012
… Tric-a gene ablation inhibited RyR-mediated hyperpolarization signaling to stimulate voltage-dependent Ca2+ influx, and adversely enhanced IP3R-mediated Ca2+ transients by overloading Ca2+ stores in VSMCs. …
NAID 130001888722

Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo

高田則雄,三嶋恒子,久恒智博,永井てるみ,戎井悦子,御子柴克彦,平瀬肇
The Journal of Neuroscience 31(49), 18155-18165, 2011-12-00
… The elevation of astrocytic [Ca2+] is crucial in this type of synaptic plasticity, as the plasticity could not be induced in inositol-1,4,5-trisphosphate receptor type 2 knock-out (IP3R2-KO) mice, in which astrocytic [Ca2+] surges are diminished. … Moreover, NBM stimulation led to a significant increase in the extracellular concentration of the NMDAR coagonist d-serine in wild-type mice when compared to IP3R2-KO mice. …
NAID 120004161559

Intracellular CICR -associated pharmacological mechanism of action of antiepileptic drugs

Zhu Gang,Okada Motohiro,Yoshida Shukuko,Kaneko Sunao
Epilepsy & Seizure 3(1), 154-162, 2010
… Especially, we have investigated the functional importance of Ca2+ mobilization, composed of influx through Ca2+ channels and output through ryanodine receptor (RyR)- and inositol-triphosphate receptor (IP3R)-sensitive intracellular Ca2+-induced Ca2+ releasing systems (CICRs), in the pathogenesis of epilepsy and the pharmacological mechanism of AEDs. …
NAID 130000324311

「inositol 1,4,5-trisphosphate receptor」

inositol 1,4,5-trisphosphate receptor, type 3
Identifiers
Symbol	ITPR3
Entrez	3710
HUGO	6182
OMIM	147267
RefSeq	NM_002224
UniProt	Q14573
Other data
Locus	Chr. 6 p21.31

inositol 1,4,5-trisphosphate receptor, type 2
Identifiers
Symbol	ITPR2
Entrez	3709
HUGO	structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181 Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181
OMIM	600144
RefSeq	NM_002223
UniProt	Q14571
Other data
Locus	Chr. 12 p11.23

inositol 1,4,5-trisphosphate receptor, type 1
	Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor
Identifiers
Symbol	ITPR1
Entrez	3708
HUGO	6180
OMIM	147265
RefSeq	NM_002222
UniProt	Q14643
Other data
Locus	Chr. 3 p26.1