- 同
- CXCL10
- 同
- CXCL10
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- the 9th letter of the Roman alphabet (同)i
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/28 19:43:35」(JST)
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Chemokine (C-X-C motif) ligand 10 |
PDB rendering based on 1o7z.
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Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1LV9, 1O7Y, 1O7Z, 1O80
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Identifiers |
Symbols |
CXCL10 ; C7; IFI10; INP10; IP-10; SCYB10; crg-2; gIP-10; mob-1 |
External IDs |
OMIM: 147310 MGI: 1352450 HomoloGene: 1203 GeneCards: CXCL10 Gene |
Gene ontology |
Molecular function |
• receptor binding
• protein binding
• chemokine activity
• heparin binding
• cAMP-dependent protein kinase regulator activity
• CXCR3 chemokine receptor binding
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Cellular component |
• extracellular region
• extracellular space
• external side of plasma membrane
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Biological process |
• chemotaxis
• inflammatory response
• immune response
• signal transduction
• cell surface receptor signaling pathway
• G-protein coupled receptor signaling pathway
• cell-cell signaling
• muscle organ development
• blood circulation
• positive regulation of cell proliferation
• response to cold
• response to gamma radiation
• T cell chemotaxis
• regulation of T cell chemotaxis
• response to auditory stimulus
• negative regulation of angiogenesis
• positive regulation of cAMP metabolic process
• response to vitamin D
• cellular response to heat
• endothelial cell activation
• regulation of cell proliferation
• positive regulation of cAMP-mediated signaling
• negative regulation of myoblast differentiation
• regulation of protein kinase activity
• positive regulation of transcription from RNA polymerase II promoter
• positive regulation of release of sequestered calcium ion into cytosol
• defense response to virus
• chemokine-mediated signaling pathway
• cellular response to lipopolysaccharide
• positive regulation of monocyte chemotaxis
• regulation of endothelial tube morphogenesis
• negative regulation of myoblast fusion
• positive regulation of T cell migration
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
3627 |
15945 |
Ensembl |
ENSG00000169245 |
ENSMUSG00000034855 |
UniProt |
P02778 |
P17515 |
RefSeq (mRNA) |
NM_001565 |
NM_021274 |
RefSeq (protein) |
NP_001556 |
NP_067249 |
Location (UCSC) |
Chr 4:
76.02 – 76.02 Mb |
Chr 5:
92.35 – 92.35 Mb |
PubMed search |
[1] |
[2] |
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C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene.[1][2] C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.
Contents
- 1 Gene
- 2 Function
- 3 Structure
- 4 Clinical significance
- 5 References
- 6 Further reading
Gene
The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines.[3]
Function
CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts.[1] CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.[4][5]
This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.[6]
Structure
The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92 Å.[7] The Protein Data Bank accession codes for the structures of CXCL10 are 1lv9, 1o7y, and 1o80.
Clinical significance
Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.[8][9] CXCL10 in plasma is mirrored by intrahepatic CXCL10 mRNA, and both strikingly predict the first days of elimination of HCV RNA (“first phase decline”) during interferon/ribavirin therapy for all HCV genotypes.[10] This also applies for patients co-infected with HIV, where pre-treatment IP-10 levels below 150 pg/mL are predictive of a favorable response, and may thus be useful in encouraging these otherwise difficult-to-treat patients to initiate therapy.[11]
References
- ^ a b Luster AD, Unkeless JC, Ravetch JV (1985). "Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins". Nature 315 (6021): 672–6. doi:10.1038/315672a0. PMID 3925348.
- ^ Luster AD, Jhanwar SC, Chaganti RS, Kersey JH, Ravetch JV (May 1987). "Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2868–71. doi:10.1073/pnas.84.9.2868. PMC 304761. PMID 2437586.
- ^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098.
- ^ Dufour JH, Dziejman M, Liu MT, Leung JH, Lane TE, Luster AD (April 2002). "IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking". J. Immunol. 168 (7): 3195–204. PMID 11907072.
- ^ Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G (July 1995). "Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo". J. Exp. Med. 182 (1): 155–62. doi:10.1084/jem.182.1.155. PMC 2192108. PMID 7540647.
- ^ Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD (August 2002). "The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions". Biochemistry 41 (33): 10418–25. doi:10.1021/bi026020q. PMID 12173928.
- ^ Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR (May 2003). "Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine". Structure 11 (5): 521–32. doi:10.1016/S0969-2126(03)00070-4. PMID 12737818.
- ^ Romero AI, Lagging M, Westin J, Dhillon AP, Dustin LB, Pawlotsky JM, Neumann AU, Ferrari C, Missale G, Haagmans BL, Schalm SW, Zeuzem S, Negro F, Verheij-Hart E, Hellstrand K (October 2006). "Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection". J. Infect. Dis. 194 (7): 895–903. doi:10.1086/507307. PMID 16960776.
- ^ Lagging M, Romero AI, Westin J, Norkrans G, Dhillon AP, Pawlotsky JM, Zeuzem S, von Wagner M, Negro F, Schalm SW, Haagmans BL, Ferrari C, Missale G, Neumann AU, Verheij-Hart E, Hellstrand K (December 2006). "IP-10 predicts viral response and therapeutic outcome in difficult-to-treat patients with HCV genotype 1 infection". Hepatology 44 (6): 1617–25. doi:10.1002/hep.21407. PMID 17133471.
- ^ Askarieh G, Alsiö A, Pugnale P, Negro F, Ferrari C, Neumann AU, Pawlotsky JM, Schalm SW, Zeuzem S, Norkrans G, Westin J, Söderholm J, Hellstrand K, Lagging M (May 2010). "Systemic and intrahepatic interferon-gamma-inducible protein 10 kDa predicts the first-phase decline in hepatitis C virus RNA and overall viral response to therapy in chronic hepatitis C". Hepatology 51 (5): 1523–30. doi:10.1002/hep.23509. PMID 20186843.
- ^ Falconer K, Askarieh G, Weis N, Hellstrand K, Alaeus A, Lagging M (July 2010). "IP-10 predicts the first phase decline of HCV RNA and overall viral response to therapy in patients co-infected with chronic hepatitis C virus infection and HIV". Scand J Infect Dis 42 (11–12): 100824014139078. doi:10.3109/00365548.2010.498019. PMID 20608766.
Further reading
- Farber JM (1997). "Mig and IP-10: CXC chemokines that target lymphocytes". J. Leukoc. Biol. 61 (3): 246–57. PMID 9060447.
- Neville LF, Mathiak G, Bagasra O (1998). "The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily". Cytokine Growth Factor Rev. 8 (3): 207–19. doi:10.1016/S1359-6101(97)00015-4. PMID 9462486.
PDB gallery
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1lv9: CXCR3 Binding Chemokine IP-10/CXCL10
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1o7y: CRYSTAL STRUCTURE OF IP-10 M-FORM
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1o7z: CRYSTAL STRUCTURE OF IP-10 T-FORM
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1o80: CRYSTAL STRUCTURE OF IP-10 H-FORM
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Cell signaling: cytokines
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By family |
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By function/
cell |
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Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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UpToDate Contents
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English Journal
- Necrotic cell death and suppression of T-cell immunity characterized acute liver failure due to drug-induced liver injury.
- Kakisaka K1, Kataoka K2, Suzuki Y2, Okada Y2, Yoshida Y2, Kuroda H2, Takikawa Y2.
- Cytokine.Cytokine.2016 Oct;86:21-8. doi: 10.1016/j.cyto.2016.07.010. Epub 2016 Jul 19.
- BACKGROUND & AIMS: The aim of this study was to investigate the clinical characteristics and pathophysiology of drug-induced liver injury (DILI) - acute liver failure (ALF).METHODS: The patients with acute liver injury (ALI) including ALF from 2009 to 2014 were analyzed. The hepatic encephalopat
- PMID 27442007
- Effect of LTRA on IP-10-induced eosinophil adhesion to ICAM-1.
- Noguchi T1, Nakagome K2, Kobayashi T1, Ueda Y3, Uchida Y4, Soma T4, Nakamoto H5, Nagata M4.
- Allergology international : official journal of the Japanese Society of Allergology.Allergol Int.2016 Sep;65S:S62-S64. doi: 10.1016/j.alit.2016.04.015. Epub 2016 Jun 7.
- PMID 27282211
- Oxidative products from alcohol metabolism differentially modulate pro-inflammatory cytokine expression in Kupffer cells and hepatocytes.
- Dong D1, Zhong W1, Sun Q2, Zhang W1, Sun X1, Zhou Z3.
- Cytokine.Cytokine.2016 Sep;85:109-19. doi: 10.1016/j.cyto.2016.06.014. Epub 2016 Jun 14.
- Pro-inflammatory cytokines play a vital role in the pathogenesis of alcoholic steatohepatitis. The present study was to determine the role of alcohol-induced oxidative stress in modulating cytokine production. A rat model of alcohol consumption was used to determine alcohol-induced hepatic cytokine
- PMID 27314544
Japanese Journal
- Effect of LTRA on IP-10-induced eosinophil adhesion to ICAM-1
- Clinical features and outcome of acute exacerbation of interstitial pneumonia associated with connective tissue disease.
Related Links
- C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene. C-X-C motif chemokine 10 is a small ...
- Human CXCL10 / IP-10 Immunoassay kit. CXCL10は、77アミノ酸のタンパク質で あり、IFN-γに応答した、単球、内皮細胞、線維芽細胞などの細胞種から分泌されます。 CXCL10は、単球やマクロファージ、T細胞、NK細胞、樹状細胞に対する化学誘導、T ...
Related Pictures
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