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- IP-10
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- IP-10
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/11 23:06:26」(JST)
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Chemokine (C-X-C motif) ligand 10 |
PDB rendering based on 1o7z.
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Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1LV9, 1O7Y, 1O7Z, 1O80
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Identifiers |
Symbols |
CXCL10 ; C7; IFI10; INP10; IP-10; SCYB10; crg-2; gIP-10; mob-1 |
External IDs |
OMIM: 147310 MGI: 1352450 HomoloGene: 1203 GeneCards: CXCL10 Gene |
Gene ontology |
Molecular function |
• receptor binding
• protein binding
• chemokine activity
• heparin binding
• cAMP-dependent protein kinase regulator activity
• CXCR3 chemokine receptor binding
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Cellular component |
• extracellular region
• extracellular space
• external side of plasma membrane
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Biological process |
• chemotaxis
• inflammatory response
• immune response
• signal transduction
• cell surface receptor signaling pathway
• G-protein coupled receptor signaling pathway
• cell-cell signaling
• muscle organ development
• blood circulation
• positive regulation of cell proliferation
• response to cold
• response to gamma radiation
• T cell chemotaxis
• regulation of T cell chemotaxis
• response to auditory stimulus
• negative regulation of angiogenesis
• positive regulation of cAMP metabolic process
• response to vitamin D
• cellular response to heat
• endothelial cell activation
• regulation of cell proliferation
• positive regulation of cAMP-mediated signaling
• negative regulation of myoblast differentiation
• regulation of protein kinase activity
• positive regulation of transcription from RNA polymerase II promoter
• positive regulation of release of sequestered calcium ion into cytosol
• defense response to virus
• chemokine-mediated signaling pathway
• cellular response to lipopolysaccharide
• positive regulation of monocyte chemotaxis
• regulation of endothelial tube morphogenesis
• negative regulation of myoblast fusion
• positive regulation of T cell migration
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
3627 |
15945 |
Ensembl |
ENSG00000169245 |
ENSMUSG00000034855 |
UniProt |
P02778 |
P17515 |
RefSeq (mRNA) |
NM_001565 |
NM_021274 |
RefSeq (protein) |
NP_001556 |
NP_067249 |
Location (UCSC) |
Chr 4:
76.02 – 76.02 Mb |
Chr 5:
92.35 – 92.35 Mb |
PubMed search |
[1] |
[2] |
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C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene.[1][2] C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.
Contents
- 1 Gene
- 2 Function
- 3 Structure
- 4 Clinical significance
- 5 References
- 6 Further reading
Gene
The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines.[3]
Function
CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts.[1] CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.[4][5]
This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.[6]
Structure
The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92 Å.[7] The Protein Data Bank accession codes for the structures of CXCL10 are 1lv9, 1o7y, and 1o80.
Clinical significance
Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.[8][9] CXCL10 in plasma is mirrored by intrahepatic CXCL10 mRNA, and both strikingly predict the first days of elimination of HCV RNA (“first phase decline”) during interferon/ribavirin therapy for all HCV genotypes.[10] This also applies for patients co-infected with HIV, where pre-treatment IP-10 levels below 150 pg/mL are predictive of a favorable response, and may thus be useful in encouraging these otherwise difficult-to-treat patients to initiate therapy.[11]
References
- ^ a b Luster AD, Unkeless JC, Ravetch JV (1985). "Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins". Nature 315 (6021): 672–6. doi:10.1038/315672a0. PMID 3925348.
- ^ Luster AD, Jhanwar SC, Chaganti RS, Kersey JH, Ravetch JV (May 1987). "Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2868–71. doi:10.1073/pnas.84.9.2868. PMC 304761. PMID 2437586.
- ^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098.
- ^ Dufour JH, Dziejman M, Liu MT, Leung JH, Lane TE, Luster AD (April 2002). "IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking". J. Immunol. 168 (7): 3195–204. PMID 11907072.
- ^ Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G (July 1995). "Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo". J. Exp. Med. 182 (1): 155–62. doi:10.1084/jem.182.1.155. PMC 2192108. PMID 7540647.
- ^ Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD (August 2002). "The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions". Biochemistry 41 (33): 10418–25. doi:10.1021/bi026020q. PMID 12173928.
- ^ Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR (May 2003). "Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine". Structure 11 (5): 521–32. doi:10.1016/S0969-2126(03)00070-4. PMID 12737818.
- ^ Romero AI, Lagging M, Westin J, Dhillon AP, Dustin LB, Pawlotsky JM, Neumann AU, Ferrari C, Missale G, Haagmans BL, Schalm SW, Zeuzem S, Negro F, Verheij-Hart E, Hellstrand K (October 2006). "Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection". J. Infect. Dis. 194 (7): 895–903. doi:10.1086/507307. PMID 16960776.
- ^ Lagging M, Romero AI, Westin J, Norkrans G, Dhillon AP, Pawlotsky JM, Zeuzem S, von Wagner M, Negro F, Schalm SW, Haagmans BL, Ferrari C, Missale G, Neumann AU, Verheij-Hart E, Hellstrand K (December 2006). "IP-10 predicts viral response and therapeutic outcome in difficult-to-treat patients with HCV genotype 1 infection". Hepatology 44 (6): 1617–25. doi:10.1002/hep.21407. PMID 17133471.
- ^ Askarieh G, Alsiö A, Pugnale P, Negro F, Ferrari C, Neumann AU, Pawlotsky JM, Schalm SW, Zeuzem S, Norkrans G, Westin J, Söderholm J, Hellstrand K, Lagging M (May 2010). "Systemic and intrahepatic interferon-gamma-inducible protein 10 kDa predicts the first-phase decline in hepatitis C virus RNA and overall viral response to therapy in chronic hepatitis C". Hepatology 51 (5): 1523–30. doi:10.1002/hep.23509. PMID 20186843.
- ^ Falconer K, Askarieh G, Weis N, Hellstrand K, Alaeus A, Lagging M (July 2010). "IP-10 predicts the first phase decline of HCV RNA and overall viral response to therapy in patients co-infected with chronic hepatitis C virus infection and HIV". Scand J Infect Dis 42 (11–12): 100824014139078. doi:10.3109/00365548.2010.498019. PMID 20608766.
Further reading
- Farber JM (1997). "Mig and IP-10: CXC chemokines that target lymphocytes". J. Leukoc. Biol. 61 (3): 246–57. PMID 9060447.
- Neville LF, Mathiak G, Bagasra O (1998). "The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily". Cytokine Growth Factor Rev. 8 (3): 207–19. doi:10.1016/S1359-6101(97)00015-4. PMID 9462486.
PDB gallery
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1lv9: CXCR3 Binding Chemokine IP-10/CXCL10
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1o7y: CRYSTAL STRUCTURE OF IP-10 M-FORM
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1o7z: CRYSTAL STRUCTURE OF IP-10 T-FORM
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1o80: CRYSTAL STRUCTURE OF IP-10 H-FORM
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Cell signaling: cytokines
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By family |
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cell |
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Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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UpToDate Contents
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English Journal
- Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.
- Anagandula M1, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G.
- Journal of medical virology.J Med Virol.2014 Aug;86(8):1402-11. doi: 10.1002/jmv.23835. Epub 2013 Nov 19.
- Type 1 diabetes mellitus is believed to be triggered, in part, by one or more environmental factors and human enteroviruses (HEVs) are among the candidates. Therefore, this study has examined whether two strains of HEV may differentially affect the induction of genes involved in pathways leading to
- PMID 24249667
- Cellular Stress Amplifies TLR3/4-Induced CXCL1/2 Gene Transcription in Mononuclear Phagocytes via RIPK1.
- Zhao C1, Pavicic PG Jr1, Datta S1, Sun D1, Novotny M1, Hamilton TA2.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Jul 15;193(2):879-88. doi: 10.4049/jimmunol.1303396. Epub 2014 Jun 11.
- The impact of environmental stressors on the magnitude of specific chemokine gene expression was examined in mouse bone marrow-derived macrophages stimulated through various TLRs. Levels of TLR-stimulated CXCL1 and CXCL2 but not CXCL10 or CCL5 mRNAs were selectively enhanced (>10-fold) in stresse
- PMID 24920846
- Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin.
- Bsibsi M1, Peferoen LA, Holtman IR, Nacken PJ, Gerritsen WH, Witte ME, van Horssen J, Eggen BJ, van der Valk P, Amor S, van Noort JM.
- Acta neuropathologica.Acta Neuropathol.2014 Jul 5. [Epub ahead of print]
- Activated microglia and macrophages play a key role in driving demyelination during multiple sclerosis (MS), but the factors responsible for their activation remain poorly understood. Here, we present evidence for a dual-trigger role of IFN-γ and alpha B-crystallin (HSPB5) in this context. In MS-af
- PMID 24997049
Japanese Journal
- CXCL10を介したIFN-βの悪性黒色腫に対する抗腫瘍効果 (第132回成医会総会一般演題)
- HTLV-1関連脊髄症(HAM) : 分子病態解明による治療薬開発の新展開 (第5土曜特集 免疫性神経疾患 : 病態解明と治療の最前線) -- (その他の免疫性神経疾患)
Related Links
- Recombinant human CXCL10 (IP-10)の製品ページです。Interferon Inducible Protein 1 と呼ばれることもあります。用途が確認されているアプリケーションはFAです。種交差はHuman、標識はPurified。関連製品をお探しの場合は、製品検索を ...
- CXCL10は、77アミノ酸のタンパク質であり、IFN-γに応答した、単球、内皮細胞、線維芽細胞などの細胞種から分泌されます。CXCL10は、単球やマクロファージ、T細胞、NK細胞、樹状細胞に対する化学誘導、T細胞の内皮細胞への接着、抗 ...
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