同: insulin-like growth factor binding protein-1

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/25 20:39:05」(JST)

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Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.^[1]^[2]

Function[edit]

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

References[edit]

^ Brinkman A, Groffen C, Kortleve DJ, Geurts van Kessel A, Drop SL (Jan 1989). "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)". EMBO J 7 (8): 2417–23. PMC 457109. PMID 2461294.
^ ^a ^b "Entrez Gene: IGFBP1 insulin-like growth factor binding protein 1".

UpToDate Contents

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English Journal

Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou).

Kawaguchi K, Kaneko N, Fukuda M, Nakano Y, Kimura S, Hara A, Shimizu M.SourceFaculty of Fisheries Sciences, Hokkaido University, 3-1-1 Minato, Hakodate, Hokkaido 041-8611, Japan.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2013 Jun;165(2):191-8. doi: 10.1016/j.cbpa.2013.02.029. Epub 2013 Mar 6.
Two subtypes of insulin-like growth factor binding protein (IGFBP)-1 are present in salmon blood and they are both up-regulated under catabolic conditions such as stress. The present study examined effects of fasting and re-feeding on IGFBP-1a (28-kDa form) and IGFBP-1b (22-kDa form) both at mRNA an
PMID 23474252

Effects of lifestyle on plasma levels of the IGF system and the antioxidants coenzyme Q10 and vitamin E in Kenyan rural and urban populations.

Theuri G, Dallner G, Brismar K, Tekle M.SourceKenyatta University, School of Applied Human Sciences, Department of Exercise Recreation and Sports Science, Nairobi, Kenya.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.Growth Horm IGF Res.2013 Jun;23(3):68-75. doi: 10.1016/j.ghir.2013.01.003. Epub 2013 Feb 26.
OBJECTIVE: Overnight fasting blood plasma insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-1 (IGFBP-1), coenzyme Q10, (CoQ) vitamin E and plasma lipids were compared between a semi-nomadic Samburu population and relatively urbanized cohorts from Nairobi, Kenya.RESEARC
PMID 23452916

Animal Protein Intakes during Early Life and Adolescence Differ in Their Relation to the Growth Hormone-Insulin-Like-Growth-Factor Axis in Young Adulthood.

Joslowski G, Remer T, Assmann KE, Krupp D, Cheng G, Garnett SP, Kroke A, Wudy SA, Günther AL, Buyken AE.SourceIEL-Nutritional Epidemiology, University of Bonn, DONALD Study at the Research Institute of Child Nutrition, Dortmund, Germany.
The Journal of nutrition.J Nutr.2013 May 22. [Epub ahead of print]
Recent studies provide evidence that insulin-like-growth-factor I (IGF-I) and its binding proteins (IGFBP) IGFBP-2 and IGFBP-3 are related to the risk of several common cancers. It remains to be clarified whether their concentrations can be programmed by protein intake from different sources during
PMID 23700336

Japanese Journal

P1-13-2 低酸素がインスリン様成長因子-I(IGF-I)とその結合タンパク-1(IGFBP-1)におよぼす影響(Group21 妊娠・分娩・産褥の生理・病理4 IUGR・PIH,一般演題,第63回日本産科婦人科学会学術講演会)

綱脇智法,酒井啓治,岩下光利
日本産科婦人科學會雜誌 63(2), 525, 2011-02-01
NAID 110008509001

K-31 ヒト子宮内膜間質細胞(ESC)の脱落膜化によって誘導されるIGFBP-1,PRL遺伝子発現におけるepigenetic調節機構の関与(高得点演題7 生殖,第63回日本産科婦人科学会学術講演会)

田村功,浅田裕美,田邊学,李理華,木塚文恵,前川亮,竹谷俊明,山縣芳明,田村博史,杉野法広
日本産科婦人科學會雜誌 63(2), 453, 2011-02-01
NAID 110008508786

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★リンクテーブル★

リンク元	「インスリン様増殖因子結合タンパク質1」「insulin-like growth factor binding protein 1」「インスリン様成長因子結合タンパク質1」
関連記事	「IGFBP」「IGF」

「インスリン様増殖因子結合タンパク質1」

Insulin-like growth factor binding protein 1
	; PDB rendering based on 1zt3.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1ZT3, 1ZT5, 2DSQ
Identifiers
Symbols	IGFBP1; AFBP; IBP1; IGF-BP25; PP12; hIGFBP-1
External IDs	OMIM: 146730 MGI: 96436 HomoloGene: 498 ChEMBL: 4178 GeneCards: IGFBP1 Gene
Gene Ontology
Molecular function	• insulin-like growth factor binding;
Cellular component	• extracellular region; • extracellular space;
Biological process	• activation of signaling protein activity involved in unfolded protein response; • signal transduction; • insulin receptor signaling pathway; • positive regulation of cell growth; • endoplasmic reticulum unfolded protein response; • tissue regeneration; • cellular protein metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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