WordNet
- strike with horror or terror; "The news of the bombing shocked her"
- (pathology) bodily collapse or near collapse caused by inadequate oxygen delivery to the cells; characterized by reduced cardiac output and rapid heartbeat and circulatory insufficiency and pallor; "loss of blood is an important cause of shock"
- subject to electrical shocks
- the violent interaction of individuals or groups entering into combat; "the armies met in the shock of battle" (同)impact
- an unpleasant or disappointing surprise; "it came as a shock to learn that he was injured" (同)blow
- an instance of agitation of the earths crust; "the first shock of the earthquake came shortly after noon while workers were at lunch" (同)seismic disturbance
- a bushy thick mass (especially hair); "he had an unruly shock of black hair"
- a pile of sheaves of grain set on end in a field to dry; stalks of Indian corn set up in a field; "corn is bound in small sheaves and several sheaves are set up together in shocks"; "whole fields of wheat in shock"
- surprise greatly; knock someones socks off; "I was floored when I heard that I was promoted" (同)floor, ball over, blow out of the water, take aback
- strike with disgust or revulsion; "The scandalous behavior of this married woman shocked her friends" (同)offend, scandalize, scandalise, appal, appall, outrage
- collect or gather into shocks; "shock grain"
- collide violently
- provide with heat; "heat the house"
- a form of energy that is transferred by a difference in temperature (同)heat energy
- make hot or hotter; "the sun heats the oceans"; "heat the water on the stove" (同)heat_up
- gain heat or get hot; "The room heated up quickly" (同)hot up, heat_up
- the trait of being intensely emotional (同)warmth, passion
- the sensation caused by heat energy (同)warmth
- a preliminary race in which the winner advances to a more important race
- the 5th letter of the Hebrew alphabet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- marked by emotional heat; vehement; "a heated argument"
- made warm or hot (`het is a dialectal variant of `heated' (同)heated up, het, het_up
PrepTutorEJDIC
- 〈C〉(衝突・爆発などの)『衝撃』,(地震の)震動,電撃 / 〈C〉〈U〉(精神的)『打撃』,ショック / 〈U〉ショック症 / 《しばしば受動態で》〈人〉‘を'『ぎょっとさせる』,ひどく驚かせる / (治療のため)〈人・動物〉‘に'電気ショクを与える
- (乾燥させるために立てかけた)穀類の刈り束 / 〈穀類〉‘を'刈り束にする
- (髪の毛の)もじゃもじゃの固まり《+『of』+『名』》
- 〈U〉『熱さ』,『暑さ』,熱い状態 / 〈U〉熱度,温度 / 〈U〉(家などの)暖房装置 / 〈U〉熱心,熱烈;(物事の)最高潮《+『of』+『名』》 / 〈U〉(エネルギーとしての)熱 / 〈C〉(競技の)1回,1ラウンド / …‘を'『熱する』,暖める《+『up』+『名,』+『名』+『up』》 / …‘を'興奮させる,怒らせる《+『up』+『名,』+『名』+『up』》 / 熱くなる,暖まる《+『up』》
- （雌の）発情（in heatとして使う）・金・銭・緊迫、プレッシャー、批判、批評、警察の追跡
- 彼は,彼が / 《指す人の性別が分からないか,または分かる必要のない場合に》その人,あの人,自分 / 《he who(that)の形で》《文》…するものはだれでも / (動物の)おす(雄)
- 鬼ごっこ(tag,tick,tig)
- 蛋白(たんばく)質
- 熱せられた / 興奮した,怒った
UpToDate Contents
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- 1. ヘノッホ・シェーンライン紫斑病（IgA血管炎）：臨床症状および診断 henoch schonlein purpura immunoglobulin a vasculitis clinical manifestations and diagnosis
- 2. ヘノッホ・シェーンライン紫斑病 (IgA血管炎)の腎症状 renal manifestations of henoch schonlein purpura iga vasculitis
- 3. ヘノッホ・シェーンライン紫斑病（IgA血管炎）：マネージメント henoch schonlein purpura immunoglobulin a vasculitis management
- 4. IgA腎症：移植後の再発 iga nephropathy recurrence after transplantation
- 5. 血管炎の消化器症状 gastrointestinal manifestations of vasculitis
English Journal
- Hsp90 directly interacts, in vitro, with amyloid structures and modulates their assembly and disassembly.
- Schirmer C1, Lepvrier E1, Duchesne L2, Decaux O1, Thomas D1, Delamarche C1, Garnier C3.
- Biochimica et biophysica acta.Biochim Biophys Acta.2016 Nov;1860(11 Pt A):2598-609. doi: 10.1016/j.bbagen.2016.07.033. Epub 2016 Aug 3.
- BACKGROUND: The 90kDa heat shock protein (Hsp90) participates in regulating the homeostasis of cellular proteins and was considered one of the key chaperones involved in the control and regulation of amyloid deposits. Hsp90 interacts with the amyloid protein tau through tau aggregation-prone regions
- PMID 27495389
- Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis.
- Koca İ1, Özgür A2, Er M3, Gümüş M3, Açikalin Coşkun K2, Tutar Y4.
- European journal of medicinal chemistry.Eur J Med Chem.2016 Oct 21;122:280-90. doi: 10.1016/j.ejmech.2016.06.032. Epub 2016 Jun 23.
- Invasive ductal carcinoma is the most common breast malignancies tumors and has tendency to bone metastases. Many oncogenic client proteins involved in formation of metastatic pathways. Stabilization, regulation, and maintenance of these oncogenic client proteins are provided with Heat Shock Protein
- PMID 27376491
- Design and synthesis of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamides as novel Hsp90 inhibitors.
- Liang C1, Hao H1, Wu X1, Li Z2, Zhu J3, Lu C1, Shen Y4.
- European journal of medicinal chemistry.Eur J Med Chem.2016 Oct 4;121:272-82. doi: 10.1016/j.ejmech.2016.05.033. Epub 2016 May 20.
- Heat shock protein 90 (Hsp90) is an attractive chemotherapeutic target for antitumor drug development. Herein, we reported the design and synthesis of two series of novel N-(5-chloro-2,4-dihydroxybenzoyl)-1,2,3,4-tetrahydroisoquinoline-3- carboxamides as Hsp90 inhibitors using (S)-Tic (1,2,3,4-tetra
- PMID 27266997
Japanese Journal
- Capsaicin partially mimics heat in mouse fibroblast cells in vitro
- Naunyn-Schmiedeberg's Archives of Pharmacology 390(3), 281-289, 2017-03-01
- NAID 120005982994
- Heat shock protein 90α is a potential serological biomarker of acute rejection after renal transplantation.
- 札幌医学雑誌 = The Sapporo Medical Journal 85(1-6), 66-67, 2016-12-01
- NAID 120005999114
- PU-H71, a novel Hsp90 inhibitor, as a potential cancer-specific sensitizer to carbon-ion beam therapy
- Journal of radiation research 57(5), 572-575, 2016-09
- NAID 120005947335
Related Links
- 言い換えると，熱ショックタンパク質（Heat Shock Protein, HSP）は，新たに発現した，あるいは正しくない構造を持つタンパク質のリフォールディングを行い，活性を持たせる働きをします。Hsp90, Hsp70, Hsp60, Hsp40，Hsp27をはじめと
- StressMarq社では，Hsp（ヒートショックプロテイン, Heat Shock Protein）組換え体タンパク質やHsp阻害物質を，多数取りそろえています。中でもFITC標識されたGeldanamycinは，Hsp90との結合を蛍光偏光法を用いて測定することができる ...
- After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open27295069
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★リンクテーブル★
| リンク元 | 「Hsp90熱ショックタンパク質」 |
| 関連記事 | 「heat」「heat shock」「shock」「heating」「Hsp」 |
「Hsp90熱ショックタンパク質」
「heat」
- n.
- v.
- 加熱する、加温する
「heat shock」
「shock」
「heating」
- n.